spaglumic acid-2962 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the spaglumic acid-2962 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AHSP alpha hemoglobin stabilizing protein
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AREG amphiregulin
ARMC9 armadillo repeat containing 9
ASPHD1 aspartate beta-hydroxylase domain containing 1
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BIK BCL2-interacting killer (apoptosis-inducing)
BTN3A1 butyrophilin, subfamily 3, member A1
C6ORF106 chromosome 6 open reading frame 106
CD37 CD37 molecule
CDC25C cell division cycle 25C
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CEP41 centrosomal protein 41kDa
CLCF1 cardiotrophin-like cytokine factor 1
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CNTNAP1 contactin associated protein 1
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CREM cAMP responsive element modulator
CUL2 cullin 2
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DEAF1 DEAF1 transcription factor
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHODH dihydroorotate dehydrogenase (quinone)
DZIP3 DAZ interacting zinc finger protein 3
EFR3B EFR3 homolog B (S. cerevisiae)
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM50B family with sequence similarity 50, member B
FBXO22 F-box protein 22
FGF18 fibroblast growth factor 18
GPR182 G protein-coupled receptor 182
GRIP2 glutamate receptor interacting protein 2
GRM1 glutamate receptor, metabotropic 1
GRSF1 G-rich RNA sequence binding factor 1
GSK3A glycogen synthase kinase 3 alpha
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
ICOSLG inducible T-cell co-stimulator ligand
IQCE IQ motif containing E
JADE3 jade family PHD finger 3
KAT8 K(lysine) acetyltransferase 8
LATS1 large tumor suppressor kinase 1
LDHC lactate dehydrogenase C
LYRM9 LYR motif containing 9
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MEOX2 mesenchyme homeobox 2
MFN2 mitofusin 2
MYBPC3 myosin binding protein C, cardiac
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYOZ1 myozenin 1
NCAPH2 non-SMC condensin II complex, subunit H2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOX1 NADPH oxidase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
OAZ3 ornithine decarboxylase antizyme 3
PAPOLG poly(A) polymerase gamma
PDE12 phosphodiesterase 12
PDLIM2 PDZ and LIM domain 2 (mystique)
PDLIM7 PDZ and LIM domain 7 (enigma)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRDM10 PR domain containing 10
PRR4 proline rich 4 (lacrimal)
PYGB phosphorylase, glycogen; brain
QTRT1 queuine tRNA-ribosyltransferase 1
RAD51B RAD51 paralog B
RAD52 RAD52 homolog (S. cerevisiae)
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RGS19 regulator of G-protein signaling 19
RHOD ras homolog family member D
RUNX1 runt-related transcription factor 1
SLAMF7 SLAM family member 7
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC35F6 solute carrier family 35, member F6
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX13 sorting nexin 13
SPDEF SAM pointed domain containing ETS transcription factor
SPTAN1 spectrin, alpha, non-erythrocytic 1
SSTR4 somatostatin receptor 4
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TBKBP1 TBK1 binding protein 1
TBX5 T-box 5
TGFB3 transforming growth factor, beta 3
TMCO3 transmembrane and coiled-coil domains 3
UCN urocortin
ULK2 unc-51 like autophagy activating kinase 2
WFDC2 WAP four-disulfide core domain 2
WWC1 WW and C2 domain containing 1
ZBTB33 zinc finger and BTB domain containing 33
ZER1 zyg-11 related, cell cycle regulator
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF428 zinc finger protein 428
ZNF510 zinc finger protein 510
ZNF710 zinc finger protein 710
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ANAPC2 anaphase promoting complex subunit 2
ANKRD55 ankyrin repeat domain 55
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
ARRB1 arrestin, beta 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BPGM 2,3-bisphosphoglycerate mutase
C1ORF56 chromosome 1 open reading frame 56
C2CD2 C2 calcium-dependent domain containing 2
CDKL3 cyclin-dependent kinase-like 3
CEL carboxyl ester lipase
CES3 carboxylesterase 3
CHMP6 charged multivesicular body protein 6
CIC capicua transcriptional repressor
CKB creatine kinase, brain
CLGN calmegin
CTSK cathepsin K
DGAT1 diacylglycerol O-acyltransferase 1
DUSP2 dual specificity phosphatase 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
FHL3 four and a half LIM domains 3
FKBP9 FK506 binding protein 9, 63 kDa
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GDAP1 ganglioside induced differentiation associated protein 1
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNL1 guanine nucleotide binding protein-like 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPNMB glycoprotein (transmembrane) nmb
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HHLA3 HERV-H LTR-associating 3
HIST1H2BO histone cluster 1, H2bo
HIST1H4D histone cluster 1, H4d
HRAS Harvey rat sarcoma viral oncogene homolog
IFI30 interferon, gamma-inducible protein 30
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL4R interleukin 4 receptor
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
JUNB jun B proto-oncogene
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIAA0754 KIAA0754
KIF13B kinesin family member 13B
KLF2 Kruppel-like factor 2
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LRP3 low density lipoprotein receptor-related protein 3
LY96 lymphocyte antigen 96
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPKBP1 mitogen-activated protein kinase binding protein 1
MMP2 matrix metallopeptidase 2
MRPL44 mitochondrial ribosomal protein L44
MX1 MX dynamin-like GTPase 1
NAT6 N-acetyltransferase 6 (GCN5-related)
NBEAL2 neurobeachin-like 2
NHEJ1 nonhomologous end-joining factor 1
NT5C 5', 3'-nucleotidase, cytosolic
NT5M 5',3'-nucleotidase, mitochondrial
OTUD3 OTU deubiquitinase 3
PIAS3 protein inhibitor of activated STAT, 3
PKN1 protein kinase N1
PNOC prepronociceptin
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PROCR protein C receptor, endothelial
RAB13 RAB13, member RAS oncogene family
RABL6 RAB, member RAS oncogene family-like 6
RPL23AP32 ribosomal protein L23a pseudogene 32
RUSC2 RUN and SH3 domain containing 2
SALL2 spalt-like transcription factor 2
SGCE sarcoglycan, epsilon
SGMS1 sphingomyelin synthase 1
SH2D3C SH2 domain containing 3C
SLC16A4 solute carrier family 16, member 4
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SPAG4 sperm associated antigen 4
SPIDR scaffolding protein involved in DNA repair
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THBS4 thrombospondin 4
THEM6 thioesterase superfamily member 6
TOR4A torsin family 4, member A
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM36 tripartite motif containing 36
TRPS1 trichorhinophalangeal syndrome I
TUBA3C tubulin, alpha 3c
UBXN2B UBX domain protein 2B
UPP1 uridine phosphorylase 1
YIPF3 Yip1 domain family, member 3
ZBED1 zinc finger, BED-type containing 1
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF10 zinc finger protein 10
ZNF254 zinc finger protein 254
ZNF506 zinc finger protein 506
ZNF573 zinc finger protein 573
ZNF592 zinc finger protein 592
ZNF701 zinc finger protein 701
ZNF862 zinc finger protein 862
ZNHIT2 zinc finger, HIT-type containing 2