sotalol-4079 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the sotalol-4079 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACOX1 acyl-CoA oxidase 1, palmitoyl
ACTA1 actin, alpha 1, skeletal muscle
AIM1L absent in melanoma 1-like
AOAH acyloxyacyl hydrolase (neutrophil)
APP amyloid beta (A4) precursor protein
ARHGAP26 Rho GTPase activating protein 26
ARID4B AT rich interactive domain 4B (RBP1-like)
ATP11A ATPase, class VI, type 11A
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C11ORF1 chromosome 11 open reading frame 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CATSPERG catsper channel auxiliary subunit gamma
CD101 CD101 molecule
CFAP74 cilia and flagella associated protein 74
CLSTN3 calsyntenin 3
COMT catechol-O-methyltransferase
CSF1R colony stimulating factor 1 receptor
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
DCAF11 DDB1 and CUL4 associated factor 11
DTNA dystrobrevin, alpha
DTNB dystrobrevin, beta
EDN2 endothelin 2
ELSPBP1 epididymal sperm binding protein 1
EPHA3 EPH receptor A3
FCAR Fc fragment of IgA receptor
FGF4 fibroblast growth factor 4
FGL2 fibrinogen-like 2
FLT4 fms-related tyrosine kinase 4
FRMD4B FERM domain containing 4B
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR37L1 G protein-coupled receptor 37 like 1
HIST1H2BL histone cluster 1, H2bl
HOXD1 homeobox D1
HOXD13 homeobox D13
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IDI2-AS1 IDI2 antisense RNA 1
IFNA8 interferon, alpha 8
IL12RB1 interleukin 12 receptor, beta 1
IL1RL1 interleukin 1 receptor-like 1
IL32 interleukin 32
IRX4 iroquois homeobox 4
ITGB4 integrin, beta 4
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KCNK12 potassium channel, two pore domain subfamily K, member 12
KHK ketohexokinase (fructokinase)
LINC00652 long intergenic non-protein coding RNA 652
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAN2A2 mannosidase, alpha, class 2A, member 2
MAU2 MAU2 sister chromatid cohesion factor
MMRN1 multimerin 1
MPL MPL proto-oncogene, thrombopoietin receptor
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYO1B myosin IB
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NCR1 natural cytotoxicity triggering receptor 1
NF1 neurofibromin 1
NTNG1 netrin G1
OGFR opioid growth factor receptor
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDE12 phosphodiesterase 12
PDE4D phosphodiesterase 4D, cAMP-specific
PHEX phosphate regulating endopeptidase homolog, X-linked
PHF2 PHD finger protein 2
PLA2G3 phospholipase A2, group III
PLCE1 phospholipase C, epsilon 1
PML promyelocytic leukemia
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRKCQ protein kinase C, theta
PRR5 proline rich 5 (renal)
PSG4 pregnancy specific beta-1-glycoprotein 4
PTGDR2 prostaglandin D2 receptor 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PURA purine-rich element binding protein A
RGS12 regulator of G-protein signaling 12
RIMS2 regulating synaptic membrane exocytosis 2
RIN3 Ras and Rab interactor 3
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SP110 SP110 nuclear body protein
STOML1 stomatin (EPB72)-like 1
SYK spleen tyrosine kinase
TBX2 T-box 2
TDRD1 tudor domain containing 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR1 transforming growth factor, beta receptor 1
TMEM206 transmembrane protein 206
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNIK TRAF2 and NCK interacting kinase
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene
VGLL3 vestigial-like family member 3
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
ZNF345 zinc finger protein 345

decreased expression

Symbol Name
ADAM23 ADAM metallopeptidase domain 23
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALPK1 alpha-kinase 1
ARHGAP10 Rho GTPase activating protein 10
ASB7 ankyrin repeat and SOCS box containing 7
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BAGE B melanoma antigen
BMP10 bone morphogenetic protein 10
BSPRY B-box and SPRY domain containing
BTF3P11 basic transcription factor 3 pseudogene 11
C19ORF54 chromosome 19 open reading frame 54
CCDC132 coiled-coil domain containing 132
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD68 CD68 molecule
CFAP69 cilia and flagella associated protein 69
CNN1 calponin 1, basic, smooth muscle
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTC1 CTS telomere maintenance complex component 1
DAGLA diacylglycerol lipase, alpha
DLK2 delta-like 2 homolog (Drosophila)
ELP6 elongator acetyltransferase complex subunit 6
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXOC6B exocyst complex component 6B
FBXO22 F-box protein 22
FBXO31 F-box protein 31
GLS2 glutaminase 2 (liver, mitochondrial)
GMPR guanosine monophosphate reductase
GPC3 glypican 3
GRTP1 growth hormone regulated TBC protein 1
HOXA4 homeobox A4
HSPA1L heat shock 70kDa protein 1-like
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
ICK intestinal cell (MAK-like) kinase
IFI6 interferon, alpha-inducible protein 6
IFT140 intraflagellar transport 140
IRF2BP1 interferon regulatory factor 2 binding protein 1
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA1462 KIAA1462
KLF1 Kruppel-like factor 1 (erythroid)
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LIME1 Lck interacting transmembrane adaptor 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LPAR4 lysophosphatidic acid receptor 4
LUM lumican
MDFI MyoD family inhibitor
MMP2 matrix metallopeptidase 2
MTCP1 mature T-cell proliferation 1
MYLK myosin light chain kinase
NAT6 N-acetyltransferase 6 (GCN5-related)
NDE1 nudE neurodevelopment protein 1
NINJ1 ninjurin 1
NPDC1 neural proliferation, differentiation and control, 1
NT5M 5',3'-nucleotidase, mitochondrial
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OSBP2 oxysterol binding protein 2
OXCT2 3-oxoacid CoA transferase 2
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PARP3 poly (ADP-ribose) polymerase family, member 3
PCDHA5 protocadherin alpha 5
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLXNB3 plexin B3
POM121 POM121 transmembrane nucleoporin
PPL periplakin
PRSS22 protease, serine, 22
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RIBC2 RIB43A domain with coiled-coils 2
RPAP1 RNA polymerase II associated protein 1
RPH3AL rabphilin 3A-like (without C2 domains)
RPL23AP32 ribosomal protein L23a pseudogene 32
S1PR1 sphingosine-1-phosphate receptor 1
SCARA3 scavenger receptor class A, member 3
SCUBE3 signal peptide, CUB domain, EGF-like 3
SLC12A9 solute carrier family 12, member 9
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC22A18 solute carrier family 22, member 18
SPATA2L spermatogenesis associated 2-like
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYT17 synaptotagmin XVII
SYTL2 synaptotagmin-like 2
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAGLN3 transgelin 3
THSD4 thrombospondin, type I, domain containing 4
TMEM120B transmembrane protein 120B
TMEM209 transmembrane protein 209
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
WDR25 WD repeat domain 25
WNT10B wingless-type MMTV integration site family, member 10B
YY2 YY2 transcription factor
ZNF230 zinc finger protein 230
ZNF268 zinc finger protein 268
ZNF675 zinc finger protein 675
ZNF768 zinc finger protein 768
ZNF816 zinc finger protein 816
ZSCAN2 zinc finger and SCAN domain containing 2