sotalol-2918 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the sotalol-2918 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
AMPD3 adenosine monophosphate deaminase 3
ANGPT4 angiopoietin 4
APOC1 apolipoprotein C-I
APOL2 apolipoprotein L, 2
ARSA arylsulfatase A
ATP13A2 ATPase type 13A2
ATP9A ATPase, class II, type 9A
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCDC9 coiled-coil domain containing 9
CD1A CD1a molecule
CD6 CD6 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CDON cell adhesion associated, oncogene regulated
CECR1 cat eye syndrome chromosome region, candidate 1
CLCF1 cardiotrophin-like cytokine factor 1
CLEC4A C-type lectin domain family 4, member A
COL6A1 collagen, type VI, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CRAT carnitine O-acetyltransferase
CXCR3 chemokine (C-X-C motif) receptor 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOCK6 dedicator of cytokinesis 6
EXOSC2 exosome component 2
EXTL3 exostosin-like glycosyltransferase 3
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
FXYD7 FXYD domain containing ion transport regulator 7
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GLP1R glucagon-like peptide 1 receptor
GRPR gastrin-releasing peptide receptor
HDC histidine decarboxylase
HEG1 heart development protein with EGF-like domains 1
HEMK1 HemK methyltransferase family member 1
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HOXA11 homeobox A11
HOXD1 homeobox D1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IL11 interleukin 11
INE1 inactivation escape 1 (non-protein coding)
LAMA5 laminin, alpha 5
LEFTY1 left-right determination factor 1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MDFI MyoD family inhibitor
MLPH melanophilin
MUC3A mucin 3A, cell surface associated
MUC6 mucin 6, oligomeric mucus/gel-forming
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
NEBL nebulette
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOP14-AS1 NOP14 antisense RNA 1
NPFFR1 neuropeptide FF receptor 1
OVGP1 oviductal glycoprotein 1, 120kDa
PACS1 phosphofurin acidic cluster sorting protein 1
PCDHGA10 protocadherin gamma subfamily A, 10
PEX10 peroxisomal biogenesis factor 10
PIEZO2 piezo-type mechanosensitive ion channel component 2
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLSCR3 phospholipid scramblase 3
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PROL1 proline rich, lacrimal 1
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RNF17 ring finger protein 17
RNF39 ring finger protein 39
RPL7 ribosomal protein L7
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCARB2 scavenger receptor class B, member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLAMF8 SLAM family member 8
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SPDEF SAM pointed domain containing ETS transcription factor
STAT4 signal transducer and activator of transcription 4
TAPBP TAP binding protein (tapasin)
TAPBPL TAP binding protein-like
TBC1D2 TBC1 domain family, member 2
TBCD tubulin folding cofactor D
TBX6 T-box 6
TCF20 transcription factor 20 (AR1)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TK2 thymidine kinase 2, mitochondrial
TNK1 tyrosine kinase, non-receptor, 1
TRAF4 TNF receptor-associated factor 4
USP12 ubiquitin specific peptidase 12
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
VIPR2 vasoactive intestinal peptide receptor 2
WISP1 WNT1 inducible signaling pathway protein 1
ZNF205 zinc finger protein 205
ZNF484 zinc finger protein 484
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ACYP1 acylphosphatase 1, erythrocyte (common) type
ANAPC2 anaphase promoting complex subunit 2
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ANO10 anoctamin 10
AP4M1 adaptor-related protein complex 4, mu 1 subunit
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
BBS7 Bardet-Biedl syndrome 7
BPGM 2,3-bisphosphoglycerate mutase
C12ORF49 chromosome 12 open reading frame 49
CASD1 CAS1 domain containing 1
CCNJ cyclin J
CDK3 cyclin-dependent kinase 3
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CISH cytokine inducible SH2-containing protein
CREB3 cAMP responsive element binding protein 3
CRNKL1 crooked neck pre-mRNA splicing factor 1
CRYZ crystallin, zeta (quinone reductase)
DDHD2 DDHD domain containing 2
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DIXDC1 DIX domain containing 1
DNA2 DNA replication helicase/nuclease 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DOLK dolichol kinase
DTWD1 DTW domain containing 1
E2F6 E2F transcription factor 6
EMD emerin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FANCF Fanconi anemia, complementation group F
FKBP14 FK506 binding protein 14, 22 kDa
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GK3P glycerol kinase 3 pseudogene
GPR85 G protein-coupled receptor 85
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H2BN histone cluster 1, H2bn
HMGB3 high mobility group box 3
HS1BP3 HCLS1 binding protein 3
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
ICAM3 intercellular adhesion molecule 3
IFI6 interferon, alpha-inducible protein 6
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INPP1 inositol polyphosphate-1-phosphatase
KIAA0753 KIAA0753
KLF10 Kruppel-like factor 10
LINC00597 long intergenic non-protein coding RNA 597
LOC157562 uncharacterized LOC157562
LTB4R leukotriene B4 receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MPDU1 mannose-P-dolichol utilization defect 1
MYD88 myeloid differentiation primary response 88
NFS1 NFS1 cysteine desulfurase
NPIPB3 nuclear pore complex interacting protein family, member B3
NR1H3 nuclear receptor subfamily 1, group H, member 3
NT5C 5', 3'-nucleotidase, cytosolic
ODF2 outer dense fiber of sperm tails 2
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PECR peroxisomal trans-2-enoyl-CoA reductase
PMCH pro-melanin-concentrating hormone
PPARG peroxisome proliferator-activated receptor gamma
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PTGES2 prostaglandin E synthase 2
RBM7 RNA binding motif protein 7
RINT1 RAD50 interactor 1
RPAIN RPA interacting protein
RPIA ribose 5-phosphate isomerase A
RUFY2 RUN and FYVE domain containing 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC16A4 solute carrier family 16, member 4
SLC31A1 solute carrier family 31 (copper transporter), member 1
SOAT1 sterol O-acyltransferase 1
SPAG1 sperm associated antigen 1
SYF2 SYF2 pre-mRNA-splicing factor
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
THOP1 thimet oligopeptidase 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TRAPPC11 trafficking protein particle complex 11
TTC26 tetratricopeptide repeat domain 26
UBE2S ubiquitin-conjugating enzyme E2S
UNC93B1 unc-93 homolog B1 (C. elegans)
VCPKMT valosin containing protein lysine (K) methyltransferase
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae)
YEATS4 YEATS domain containing 4
ZCCHC2 zinc finger, CCHC domain containing 2
ZNF10 zinc finger protein 10
ZNF215 zinc finger protein 215
ZNF250 zinc finger protein 250
ZNF354A zinc finger protein 354A
ZNF529 zinc finger protein 529
ZNF573 zinc finger protein 573
ZNF667 zinc finger protein 667