somatoform disorder Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate. (Human Disease Ontology, DOID_4737)
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Genes

221 genes co-occuring with the disease somatoform disorder in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SCN9A sodium channel, voltage gated, type IX alpha subunit 2.28212
SCN11A sodium channel, voltage gated, type XI alpha subunit 1.55823
SCN8A sodium channel, voltage gated, type VIII alpha subunit 1.53701
SCN3A sodium channel, voltage gated, type III alpha subunit 1.52864
NGF nerve growth factor (beta polypeptide) 1.46891
CABIN1 calcineurin binding protein 1 1.42542
TAC1 tachykinin, precursor 1 1.26647
TRPA1 transient receptor potential cation channel, subfamily A, member 1 1.21608
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.15453
NME1-NME2 NME1-NME2 readthrough 1.07614
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.995705
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.993596
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.993174
SLITRK1 SLIT and NTRK-like family, member 1 0.97128
ARHGAP12 Rho GTPase activating protein 12 0.954525
TACR1 tachykinin receptor 1 0.910199
PTS 6-pyruvoyltetrahydropterin synthase 0.863865
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.826999
SCN10A sodium channel, voltage gated, type X alpha subunit 0.786803
SYNRG synergin, gamma 0.783936
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d 0.770435
HTRA1 HtrA serine peptidase 1 0.742735
BDNF brain-derived neurotrophic factor 0.716021
NPS neuropeptide S 0.711989
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.699517
LIN7C lin-7 homolog C (C. elegans) 0.679898
GLYATL1 glycine-N-acyltransferase-like 1 0.627672
VAT1 vesicle amine transport 1 0.624143
TPH1 tryptophan hydroxylase 1 0.623751
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 0.610057
CCR2 chemokine (C-C motif) receptor 2 0.604201
GHRL ghrelin/obestatin prepropeptide 0.60303
UPK1B uroplakin 1B 0.59913
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.590948
ELP2 elongator acetyltransferase complex subunit 2 0.588222
GPC6 glypican 6 0.581217
AIF1 allograft inflammatory factor 1 0.575383
ADRA1D adrenoceptor alpha 1D 0.57305
KLK3 kallikrein-related peptidase 3 0.572273
CRCP CGRP receptor component 0.567997
KIN Kin17 DNA and RNA binding protein 0.556344
EGOT eosinophil granule ontogeny transcript (non-protein coding) 0.552075
CPA3 carboxypeptidase A3 (mast cell) 0.545868
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 0.542379
LRRC32 leucine rich repeat containing 32 0.539667
PTER phosphotriesterase related 0.532314
SNX9 sorting nexin 9 0.524974
ATF3 activating transcription factor 3 0.51842
KCNK18 potassium channel, two pore domain subfamily K, member 18 0.518034
RND1 Rho family GTPase 1 0.513417
TNF tumor necrosis factor 0.512264
MYDGF myeloid-derived growth factor 0.512264
GCH1 GTP cyclohydrolase 1 0.498467
CPA4 carboxypeptidase A4 0.491597
ASIC3 acid sensing (proton gated) ion channel 3 0.491215
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.483985
C11ORF40 chromosome 11 open reading frame 40 0.483224
CAMP cathelicidin antimicrobial peptide 0.482844
TSPO translocator protein (18kDa) 0.475255
PTDSS1 phosphatidylserine synthase 1 0.474498
IL1B interleukin 1, beta 0.47374
NTF3 neurotrophin 3 0.458996
POMC proopiomelanocortin 0.455224
IFT122 intraflagellar transport 122 0.449194
BHLHE22 basic helix-loop-helix family, member e22 0.441666
CCL2 chemokine (C-C motif) ligand 2 0.436026
PEPD peptidase D 0.435275
XCL1 chemokine (C motif) ligand 1 0.433397
FDXR ferredoxin reductase 0.430393
GPC3 glypican 3 0.428891
OPRM1 opioid receptor, mu 1 0.427015
TXN thioredoxin 0.425139
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 0.41727
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.412405
CRP C-reactive protein, pentraxin-related 0.397098
WRNIP1 Werner helicase interacting protein 1 0.394491
SP9 Sp9 transcription factor 0.391513
LIN9 lin-9 DREAM MuvB core complex component 0.387051
GHSR growth hormone secretagogue receptor 0.385936
CALCA calcitonin-related polypeptide alpha 0.379256
KDM6B lysine (K)-specific demethylase 6B 0.37629
RAI1 retinoic acid induced 1 0.374438
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.372217
ASMT acetylserotonin O-methyltransferase 0.371847
SMCP sperm mitochondria-associated cysteine-rich protein 0.371477
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 0.370368
SP6 Sp6 transcription factor 0.370368
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 0.369258
MT1A metallothionein 1A 0.364085
UCN3 urocortin 3 0.363716
ARSE arylsulfatase E (chondrodysplasia punctata 1) 0.359657
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.359289
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 0.358551
CXCL8 chemokine (C-X-C motif) ligand 8 0.355604
IL6 interleukin 6 0.351555
PENK proenkephalin 0.350452
NPY neuropeptide Y 0.347511
CD4 CD4 molecule 0.344941
AMER1 APC membrane recruitment protein 1 0.340173
THAP1 THAP domain containing, apoptosis associated protein 1 0.338707
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 0.335412
PPT2 palmitoyl-protein thioesterase 2 0.334681
PDYN prodynorphin 0.332487
TSN translin 0.328834
CCK cholecystokinin 0.32701
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.32701
CRBN cereblon 0.325916
CCL3 chemokine (C-C motif) ligand 3 0.325552
PER3 period circadian clock 3 0.310652
AANAT aralkylamine N-acetyltransferase 0.30631
SUMO3 small ubiquitin-like modifier 3 0.301615
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.296931
GPANK1 G patch domain and ankyrin repeats 1 0.295851
ADRA1A adrenoceptor alpha 1A 0.293694
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.292975
SCO2 SCO2 cytochrome c oxidase assembly protein 0.292616
DCXR dicarbonyl/L-xylulose reductase 0.291898
ANXA6 annexin A6 0.291898
GPC1 glypican 1 0.289027
TES testin LIM domain protein 0.286877
SHF Src homology 2 domain containing F 0.285444
MEFV Mediterranean fever 0.285086
SUMO2 small ubiquitin-like modifier 2 0.285086
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 0.282582
GALE UDP-galactose-4-epimerase 0.28151
BCHE butyrylcholinesterase 0.279011
MED28 mediator complex subunit 28 0.269753
COX5A cytochrome c oxidase subunit Va 0.268687
THEM5 thioesterase superfamily member 5 0.264785
TFCP2 transcription factor CP2 0.260538
IL10 interleukin 10 0.256299
GFAP glial fibrillary acidic protein 0.255946
SCN1A sodium channel, voltage gated, type I alpha subunit 0.255594
SGSH N-sulfoglucosamine sulfohydrolase 0.251718
GRM5 glutamate receptor, metabotropic 5 0.24715
CRH corticotropin releasing hormone 0.246799
SCN1B sodium channel, voltage gated, type I beta subunit 0.245046
SUFU suppressor of fused homolog (Drosophila) 0.241196
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.240148
RBMS1 RNA binding motif, single stranded interacting protein 1 0.227297
PLK2 polo-like kinase 2 0.214975
OPRL1 opiate receptor-like 1 0.211261
PAX9 paired box 9 0.207245
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.205916
CD3D CD3d molecule, delta (CD3-TCR complex) 0.205585
TACR2 tachykinin receptor 2 0.204263
CCL1 chemokine (C-C motif) ligand 1 0.203604
PTH parathyroid hormone 0.201635
COMT catechol-O-methyltransferase 0.198064
SEPT9 septin 9 0.197742
HBEGF heparin-binding EGF-like growth factor 0.19742
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 0.19742
GAA glucosidase, alpha; acid 0.196779
FANCI Fanconi anemia, complementation group I 0.195183
IGF1 insulin-like growth factor 1 (somatomedin C) 0.193915
UPK3A uroplakin 3A 0.193285
BMP2K BMP2 inducible kinase 0.192657
ADRA2A adrenoceptor alpha 2A 0.188938
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 0.187415
CRHR2 corticotropin releasing hormone receptor 2 0.183541
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 0.182957
TMPRSS15 transmembrane protease, serine 15 0.180652
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 0.179802
ZNF77 zinc finger protein 77 0.177576
ACSL1 acyl-CoA synthetase long-chain family member 1 0.176757
MAOA monoamine oxidase A 0.176485
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 0.175947
MRPL49 mitochondrial ribosomal protein L49 0.172544
CALCRL calcitonin receptor-like 0.16933
CMA1 chymase 1, mast cell 0.166095
SNAP23 synaptosomal-associated protein, 23kDa 0.166095
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 0.166095
DLL1 delta-like 1 (Drosophila) 0.165874
USF2 upstream transcription factor 2, c-fos interacting 0.163729
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.163111
KNG1 kininogen 1 0.162707
STAB2 stabilin 2 0.161139
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.159124
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.158778
PYY peptide YY 0.145564
UBAP1 ubiquitin associated protein 1 0.144738
SIK1 salt-inducible kinase 1 0.14472
LIFR leukemia inhibitory factor receptor alpha 0.143445
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.142498
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) 0.141878
NPHP1 nephronophthisis 1 (juvenile) 0.140946
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 0.140808
MARK2 MAP/microtubule affinity-regulating kinase 2 0.140646
SNRPN small nuclear ribonucleoprotein polypeptide N 0.140631
WDFY2 WD repeat and FYVE domain containing 2 0.140457
PHYH phytanoyl-CoA 2-hydroxylase 0.140393
CXCL12 chemokine (C-X-C motif) ligand 12 0.140349
FBL fibrillarin 0.140283
IL6R interleukin 6 receptor 0.140038
MGAM maltase-glucoamylase 0.139776
FBLL1 fibrillarin-like 1 0.139403
AFF2 AF4/FMR2 family, member 2 0.139073
TRH thyrotropin-releasing hormone 0.139032
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.138948
SOCS3 suppressor of cytokine signaling 3 0.138805
PER2 period circadian clock 2 0.138158
FOXL2 forkhead box L2 0.137963
FLNA filamin A, alpha 0.13759
NOS2 nitric oxide synthase 2, inducible 0.136106
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.134841
CYGB cytoglobin 0.134197
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.132497
IL1RN interleukin 1 receptor antagonist 0.13202
GNAS GNAS complex locus 0.131986
LMNA lamin A/C 0.12631
ALPPL2 alkaline phosphatase, placental-like 2 0.120678
ALPP alkaline phosphatase, placental 0.12064
ALPL alkaline phosphatase, liver/bone/kidney 0.120563
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.12037
CDK5 cyclin-dependent kinase 5 0.120216
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.119866
LHCGR luteinizing hormone/choriogonadotropin receptor 0.119468
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 0.118775
PYGB phosphorylase, glycogen; brain 0.118527
PYGL phosphorylase, glycogen, liver 0.118145
TJP1 tight junction protein 1 0.11776