somatic Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

433 genes co-occuring with the biological term somatic in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ACVR1 activin A receptor, type I
ADAT2 adenosine deaminase, tRNA-specific 2
AGGF1 angiogenic factor with G patch and FHA domains 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AICDA activation-induced cytidine deaminase
AIP aryl hydrocarbon receptor interacting protein
AKAP7 A kinase (PRKA) anchor protein 7
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALK anaplastic lymphoma receptor tyrosine kinase
ANGPT2 angiopoietin 2
APC adenomatous polyposis coli
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARID1A AT rich interactive domain 1A (SWI-like)
ARID1B AT rich interactive domain 1B (SWI1-like)
ATG5 autophagy related 5
ATM ATM serine/threonine kinase
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATRN attractin
ATRX alpha thalassemia/mental retardation syndrome X-linked
AURKB aurora kinase B
AURKC aurora kinase C
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
BDNF brain-derived neurotrophic factor
BID BH3 interacting domain death agonist
BLM Bloom syndrome, RecQ helicase-like
BMF Bcl2 modifying factor
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
C1GALT1C1 C1GALT1-specific chaperone 1
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CALR calreticulin
CAMTA1 calmodulin binding transcription activator 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP8AP2 caspase 8 associated protein 2
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBY1 chibby homolog 1 (Drosophila)
CCM2 cerebral cavernous malformation 2
CCNA1 cyclin A1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCR4 chemokine (C-C motif) receptor 4
CD19 CD19 molecule
CD274 CD274 molecule
CD38 CD38 molecule
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD5 CD5 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CDC20 cell division cycle 20
CDC73 cell division cycle 73
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHD5 chromodomain helicase DNA binding protein 5
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
CKS1BP7 CDC28 protein kinase regulatory subunit 1B pseudogene 7
CKS2 CDC28 protein kinase regulatory subunit 2
CLOCK clock circadian regulator
COL2A1 collagen, type II, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COMT catechol-O-methyltransferase
CREBBP CREB binding protein
CRP C-reactive protein, pentraxin-related
CRTC1 CREB regulated transcription coactivator 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CST6 cystatin E/M
CTCF CCCTC-binding factor (zinc finger protein)
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSD cathepsin D
CUL1 cullin 1
CUL3 cullin 3
CUX1 cut-like homeobox 1
CXCR4 chemokine (C-X-C motif) receptor 4
CXXC5 CXXC finger protein 5
CYCS cytochrome c, somatic
CYLD cylindromatosis (turban tumor syndrome)
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DAXX death-domain associated protein
DAZ1 deleted in azoospermia 1
DGCR8 DGCR8 microprocessor complex subunit
DHH desert hedgehog
DICER1 dicer 1, ribonuclease type III
DMBT1 deleted in malignant brain tumors 1
DMD dystrophin
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11
DNASE1L3 deoxyribonuclease I-like 3
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOK2 docking protein 2, 56kDa
DUX4L1 double homeobox 4 like 1
DYNLRB1 dynein, light chain, roadblock-type 1
E2F1 E2F transcription factor 1
EGFR epidermal growth factor receptor
ENDOG endonuclease G
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
EPHA3 EPH receptor A3
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ERCC6 excision repair cross-complementation group 6
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EWSR1 EWS RNA-binding protein 1
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCD2 Fanconi anemia, complementation group D2
FAS Fas cell surface death receptor
FAT4 FAT atypical cadherin 4
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGF23 fibroblast growth factor 23
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FH fumarate hydratase
FLNA filamin A, alpha
FMR1 fragile X mental retardation 1
FN1 fibronectin 1
FOXL2 forkhead box L2
FOXP3 forkhead box P3
FRK fyn-related Src family tyrosine kinase
FTL ferritin, light polypeptide
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA3 GATA binding protein 3
GATA4 GATA binding protein 4
GATA5 GATA binding protein 5
GATA6 GATA binding protein 6
GH1 growth hormone 1
GJA1 gap junction protein, alpha 1, 43kDa
GJB1 gap junction protein, beta 1, 32kDa
GLI3 GLI family zinc finger 3
GLIS1 GLIS family zinc finger 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNAS GNAS complex locus
GPER1 G protein-coupled estrogen receptor 1
GREM1 gremlin 1, DAN family BMP antagonist
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRM1 glutamate receptor, metabotropic 1
GSK3B glycogen synthase kinase 3 beta
GSTP1 glutathione S-transferase pi 1
GYPA glycophorin A (MNS blood group)
H2AFX H2A histone family, member X
H3F3A H3 histone, family 3A
HAMP hepcidin antimicrobial peptide
HAND1 heart and neural crest derivatives expressed 1
HDAC11 histone deacetylase 11
HELLS helicase, lymphoid-specific
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HMGA1 high mobility group AT-hook 1
HNF1A HNF1 homeobox A
HOXC4 homeobox C4
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA2 heat shock 70kDa protein 2
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGF1R insulin-like growth factor 1 receptor
IGH immunoglobulin heavy locus
IGHV4-31 immunoglobulin heavy variable 4-31
IGL immunoglobulin lambda locus
IHH indian hedgehog
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL2RG interleukin 2 receptor, gamma
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
INS insulin
INTS6 integrator complex subunit 6
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KAT8 K(lysine) acetyltransferase 8
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KDM2B lysine (K)-specific demethylase 2B
KDM6A lysine (K)-specific demethylase 6A
KEAP1 kelch-like ECH-associated protein 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLLN killin, p53-regulated DNA replication inhibitor
KMT2C lysine (K)-specific methyltransferase 2C
KMT2D lysine (K)-specific methyltransferase 2D
KRAS Kirsten rat sarcoma viral oncogene homolog
KRIT1 KRIT1, ankyrin repeat containing
KRT10 keratin 10, type I
L1RE1 LINE1 retrotransposable element 1
LEPR leptin receptor
LHCGR luteinizing hormone/choriogonadotropin receptor
LMO1 LIM domain only 1 (rhombotin 1)
LOX lysyl oxidase
LSM10 LSM10, U7 small nuclear RNA associated
LYN LYN proto-oncogene, Src family tyrosine kinase
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MBNL1 muscleblind-like splicing regulator 1
MBNL2 muscleblind-like splicing regulator 2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MECP2 methyl CpG binding protein 2
MED12 mediator complex subunit 12
MEF2B myocyte enhancer factor 2B
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIR106A microRNA 106a
MIR135B microRNA 135b
MIR26A1 microRNA 26a-1
MIR26B microRNA 26b
MIR29B1 microRNA 29b-1
MIR302A microRNA 302a
MIR367 microRNA 367
MIR372 microRNA 372
MLH1 mutL homolog 1
MLH3 mutL homolog 3
MPL MPL proto-oncogene, thrombopoietin receptor
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH2 mutS homolog 2
MSH5 mutS homolog 5
MSH6 mutS homolog 6
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUTYH mutY homolog
MXRA5 matrix-remodelling associated 5
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBPC3 myosin binding protein C, cardiac
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
MYH11 myosin, heavy chain 11, smooth muscle
MYH7 myosin, heavy chain 7, cardiac muscle, beta
NANOG Nanog homeobox
NANOGP8 Nanog homeobox pseudogene 8
NBN nibrin
NCOA3 nuclear receptor coactivator 3
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGF nerve growth factor (beta polypeptide)
NIPBL Nipped-B homolog (Drosophila)
NKX2-5 NK2 homeobox 5
NOD1 nucleotide-binding oligomerization domain containing 1
NOTCH1 notch 1
NOTCH2 notch 2
NPAT nuclear protein, ataxia-telangiectasia locus
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
ODF2 outer dense fiber of sperm tails 2
PABPC1L poly(A) binding protein, cytoplasmic 1-like
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PALB2 partner and localizer of BRCA2
PARK2 parkin RBR E3 ubiquitin protein ligase
PAX5 paired box 5
PDCD10 programmed cell death 10
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PDYN prodynorphin
PEBP1 phosphatidylethanolamine binding protein 1
PHLDA3 pleckstrin homology-like domain, family A, member 3
PHOX2B paired-like homeobox 2b
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PIWIL4 piwi-like RNA-mediated gene silencing 4
PLCG1 phospholipase C, gamma 1
PLK1 polo-like kinase 1
PLXNB1 plexin B1
POLB polymerase (DNA directed), beta
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLG polymerase (DNA directed), gamma
POLH polymerase (DNA directed), eta
POLI polymerase (DNA directed) iota
POLM polymerase (DNA directed), mu
POMT2 protein-O-mannosyltransferase 2
POU5F1 POU class 5 homeobox 1
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRDM14 PR domain containing 14
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PSEN1 presenilin 1
PTCH1 patched 1
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRC protein tyrosine phosphatase, receptor type, C
PTX3 pentraxin 3, long
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD50 RAD50 homolog (S. cerevisiae)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RCOR2 REST corepressor 2
RECQL4 RecQ protein-like 4
REN renin
RET ret proto-oncogene
RHOH ras homolog family member H
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RUNX1 runt-related transcription factor 1
S100A8 S100 calcium binding protein A8
SAMD9L sterile alpha motif domain containing 9-like
SCHIP1 schwannomin interacting protein 1
SCN1A sodium channel, voltage gated, type I alpha subunit
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SDHAF2 succinate dehydrogenase complex assembly factor 2
SEC62 SEC62 homolog (S. cerevisiae)
SEPT4 septin 4
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SETBP1 SET binding protein 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SHH sonic hedgehog
SIRT1 sirtuin 1
SKIL SKI-like proto-oncogene
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS1 suppressor of cytokine signaling 1
SOX17 SRY (sex determining region Y)-box 17
SOX2 SRY (sex determining region Y)-box 2
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SPAST spastin
SPDYA speedy/RINGO cell cycle regulator family member A
SQSTM1 sequestosome 1
SRSF2 serine/arginine-rich splicing factor 2
ST7 suppression of tumorigenicity 7
STAG2 stromal antigen 2
STAG3 stromal antigen 3
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STK10 serine/threonine kinase 10
STK11 serine/threonine kinase 11
STK31 serine/threonine kinase 31
STMN1 stathmin 1
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TAL1 T-cell acute lymphocytic leukemia 1
TEK TEK tyrosine kinase, endothelial
TERT telomerase reverse transcriptase
TET2 tet methylcytosine dioxygenase 2
TFDP1 transcription factor Dp-1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLX3 T-cell leukemia homeobox 3
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNNI2 troponin I type 2 (skeletal, fast)
TNNI3 troponin I type 3 (cardiac)
TNNT2 troponin T type 2 (cardiac)
TOP1 topoisomerase (DNA) I
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP63 tumor protein p63
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
TRAF3 TNF receptor-associated factor 3
TRIP12 thyroid hormone receptor interactor 12
TRPS1 trichorhinophalangeal syndrome I
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TSHR thyroid stimulating hormone receptor
TUBA1A tubulin, alpha 1a
U2AF1 U2 small nuclear RNA auxiliary factor 1
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1
UBE4B ubiquitination factor E4B
UFD1L ubiquitin fusion degradation 1 like (yeast)
USP8 ubiquitin specific peptidase 8
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WAS Wiskott-Aldrich syndrome
WIF1 WNT inhibitory factor 1
WNT1 wingless-type MMTV integration site family, member 1
WNT7A wingless-type MMTV integration site family, member 7A
WRN Werner syndrome, RecQ helicase-like
XIST X inactive specific transcript (non-protein coding)
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZFHX3 zinc finger homeobox 3
ZNF335 zinc finger protein 335