smooth endoplasmic reticulum Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. (Gene Ontology, GO_0005790)
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164 proteins co-occuring with the smooth endoplasmic reticulum cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
IGF1 insulin-like growth factor 1 (somatomedin C) 2.5777
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 1.71808
INS insulin 1.37464
GHRH growth hormone releasing hormone 1.32979
POMC proopiomelanocortin 1.26656
ARMC9 armadillo repeat containing 9 1.1429
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.1296
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 0.956874
ACPP acid phosphatase, prostate 0.937377
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 0.87733
PRL prolactin 0.857095
SMC5 structural maintenance of chromosomes 5 0.841482
ALB albumin 0.761797
DNAH8 dynein, axonemal, heavy chain 8 0.758161
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 0.75317
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.752263
CAT catalase 0.738713
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.727941
SMCP sperm mitochondria-associated cysteine-rich protein 0.714126
PYGB phosphorylase, glycogen; brain 0.703507
PYGL phosphorylase, glycogen, liver 0.703067
PYGM phosphorylase, glycogen, muscle 0.700863
IGF2 insulin-like growth factor 2 0.699983
ALPPL2 alkaline phosphatase, placental-like 2 0.687701
ALPP alkaline phosphatase, placental 0.686827
ALPL alkaline phosphatase, liver/bone/kidney 0.686827
VIMP VCP-interacting membrane selenoprotein 0.671593
CDRT1 CMT1A duplicated region transcript 1 0.667693
FRY furry homolog (Drosophila) 0.66726
G6PC glucose-6-phosphatase, catalytic subunit 0.662503
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.648721
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 0.648291
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.646574
POR P450 (cytochrome) oxidoreductase 0.629892
CYB5A cytochrome b5 type A (microsomal) 0.628613
CSH2 chorionic somatomammotropin hormone 2 0.628613
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.621804
TRH thyrotropin-releasing hormone 0.619255
STX17 syntaxin 17 0.614165
G6PD glucose-6-phosphate dehydrogenase 0.60444
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.584686
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.584268
TMCC1 transmembrane and coiled-coil domain family 1 0.580922
SLC35G1 solute carrier family 35, member G1 0.575912
SMC6 structural maintenance of chromosomes 6 0.563432
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 0.560528
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 0.558871
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 0.558457
UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5 0.557629
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 0.557214
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 0.550599
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 0.549773
GCG glucagon 0.54771
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.536594
SST somatostatin 0.527569
CSTB cystatin B (stefin B) 0.514493
SMC2 structural maintenance of chromosomes 2 0.507163
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 0.494585
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 0.494585
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 0.49418
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.492966
APOB apolipoprotein B 0.490944
LPPR4 lipid phosphate phosphatase-related protein type 4 0.482064
FGF1 fibroblast growth factor 1 (acidic) 0.466799
MTTP microsomal triglyceride transfer protein 0.461998
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.453621
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.425924
FTL ferritin, light polypeptide 0.423567
GGT1 gamma-glutamyltransferase 1 0.422782
FTH1 ferritin, heavy polypeptide 1 0.421604
FBXW10 F-box and WD repeat domain containing 10 0.418077
CALB1 calbindin 1, 28kDa 0.416511
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.409479
GJB1 gap junction protein, beta 1, 32kDa 0.40714
NT5E 5'-nucleotidase, ecto (CD73) 0.401304
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 0.399363
C3ORF18 chromosome 3 open reading frame 18 0.373899
PTGR1 prostaglandin reductase 1 0.372749
DAGLA diacylglycerol lipase, alpha 0.371216
ESR1 estrogen receptor 1 0.37045
TH tyrosine hydroxylase 0.365477
SMC3 structural maintenance of chromosomes 3 0.355944
GSTA3 glutathione S-transferase alpha 3 0.345692
GSTA4 glutathione S-transferase alpha 4 0.343799
GSTA2 glutathione S-transferase alpha 2 0.343799
GSTA1 glutathione S-transferase alpha 1 0.341529
AFP alpha-fetoprotein 0.341151
MX1 MX dynamin-like GTPase 1 0.336619
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) 0.330213
EPHX2 epoxide hydrolase 2, cytoplasmic 0.328332
ACSS3 acyl-CoA synthetase short-chain family member 3 0.325327
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 0.323075
TYR tyrosinase 0.318205
CABP5 calcium binding protein 5 0.318205
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 0.317082
DGKB diacylglycerol kinase, beta 90kDa 0.31596
CABP4 calcium binding protein 4 0.312971
CABP2 calcium binding protein 2 0.310358
CKAP4 cytoskeleton-associated protein 4 0.304399
TTR transthyretin 0.298455
TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum) 0.291787
MYO5A myosin VA (heavy chain 12, myoxin) 0.290678
SEC23B Sec23 homolog B (S. cerevisiae) 0.289199
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.28846
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 0.280716
BCHE butyrylcholinesterase 0.278877
SLCO4C1 solute carrier organic anion transporter family, member 4C1 0.274468
LCMT2 leucine carboxyl methyltransferase 2 0.274101
ACOX1 acyl-CoA oxidase 1, palmitoyl 0.269335
CALR calreticulin 0.268969
VAMP5 vesicle-associated membrane protein 5 0.266408
JPH3 junctophilin 3 0.260202
AR androgen receptor 0.254017
MGAM maltase-glucoamylase 0.252202
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing 0.251114
TRPC6 transient receptor potential cation channel, subfamily C, member 6 0.250389
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 0.246769
TMBIM4 transmembrane BAX inhibitor motif containing 4 0.244962
OSBPL3 oxysterol binding protein-like 3 0.240276
NGF nerve growth factor (beta polypeptide) 0.235249
ACHE acetylcholinesterase (Yt blood group) 0.226686
TDO2 tryptophan 2,3-dioxygenase 0.225267
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.225267
CHURC1 churchill domain containing 1 0.22385
HOOK3 hook microtubule-tethering protein 3 0.22173
SPATA5 spermatogenesis associated 5 0.22173
HPX hemopexin 0.221025
RTN2 reticulon 2 0.218212
GUSB glucuronidase, beta 0.214714
DHRS4 dehydrogenase/reductase (SDR family) member 4 0.214017
REEP1 receptor accessory protein 1 0.213669
GH1 growth hormone 1 0.210894
UGP2 UDP-glucose pyrophosphorylase 2 0.210549
ACSS1 acyl-CoA synthetase short-chain family member 1 0.209513
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 0.208481
RRAS related RAS viral (r-ras) oncogene homolog 0.207794
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.205059
ZFPM1 zinc finger protein, FOG family member 1 0.203022
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 0.201672
TF transferrin 0.200999
CRAT carnitine O-acetyltransferase 0.198658
BCAP31 B-cell receptor-associated protein 31 0.189857
COASY CoA synthase 0.18859
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.187333
LMAN1 lectin, mannose-binding, 1 0.186397
GGT2 gamma-glutamyltransferase 2 0.185469
CANX calnexin 0.181227
STX5 syntaxin 5 0.179752
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.176587
GOT1L1 glutamic-oxaloacetic transaminase 1-like 1 0.175745
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 0.173814
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase 0.173543
RAB1A RAB1A, member RAS oncogene family 0.171149
MYF6 myogenic factor 6 (herculin) 0.168101
INSR insulin receptor 0.168101
CUTA cutA divalent cation tolerance homolog (E. coli) 0.16342
GPX5 glutathione peroxidase 5 0.161484
TRIM10 tripartite motif containing 10 0.160456
GPI glucose-6-phosphate isomerase 0.159658
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 0.158882
GPX4 glutathione peroxidase 4 0.158692
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.158315
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.157943
TRIM26 tripartite motif containing 26 0.15776