skin cancer Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells. (Human Disease Ontology, DOID_4159)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:4159
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Genes

73 genes associated with the disease skin cancer in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 2.73108
IRF4 interferon regulatory factor 4 2.09814
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 2.0844
TYR tyrosinase 2.04175
SLC45A2 solute carrier family 45, member 2 1.54533
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 1.47287
GRM5 glutamate receptor, metabotropic 5 1.45471
CDK10 cyclin-dependent kinase 10 1.28163
CPNE7 copine VII 1.23496
PRDM15 PR domain containing 15 1.10764
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 1.07599
NTM neurotrimin 1.02476
TP53 tumor protein p53 0.935658
CLPTM1L CLPTM1-like 0.888938
ZNF18 zinc finger protein 18 0.88034
M6PR mannose-6-phosphate receptor (cation dependent) 0.88034
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.764084
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 0.623026
PIGU phosphatidylinositol glycan anchor biosynthesis, class U 0.622745
PADI6 peptidyl arginine deiminase, type VI 0.484681
FTO fat mass and obesity associated 0.484681
NCOA6 nuclear receptor coactivator 6 0.475934
SPATA33 spermatogenesis associated 33 0.470999
DEF8 differentially expressed in FDCP 8 homolog (mouse) 0.469297
BPIFA3 BPI fold containing family A, member 3 0.464109
AFG3L1P AFG3-like AAA ATPase 1, pseudogene 0.462248
ALS2CR12 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12 0.458154
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 0.452405
MX2 MX dynamin-like GTPase 2 0.449115
ATM ATM serine/threonine kinase 0.449115
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.448286
MTAP methylthioadenosine phosphorylase 0.441721
NID1 nidogen 1 0.421161
CDK5RAP1 CDK5 regulatory subunit associated protein 1 0.420243
PARP1 poly (ADP-ribose) polymerase 1 0.418868
PHF20 PHD finger protein 20 0.412568
ANKRD11 ankyrin repeat domain 11 0.405386
ZNF276 zinc finger protein 276 0.387486
DPEP1 dipeptidase 1 (renal) 0.386676
FANCA Fanconi anemia, complementation group A 0.385511
ANXA9 annexin A9 0.382752
CSMD1 CUB and Sushi multiple domains 1 0.368223
RALY RALY heterogeneous nuclear ribonucleoprotein 0.361035
PRMT8 protein arginine methyltransferase 8 0.355737
COTL1 coactosin-like F-actin binding protein 1 0.354777
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.350892
DOCK8 dedicator of cytokinesis 8 0.349431
SAFB2 scaffold attachment factor B2 0.348788
SOX6 SRY (sex determining region Y)-box 6 0.348022
UBAC2 UBA domain containing 2 0.346597
RPS7P5 ribosomal protein S7 pseudogene 5 0.344864
NTN1 netrin 1 0.343256
TOX2 TOX high mobility group box family member 2 0.342307
PPA2 pyrophosphatase (inorganic) 2 0.341259
PARD3B par-3 family cell polarity regulator beta 0.340756
DNAH9 dynein, axonemal, heavy chain 9 0.338102
PTPRG protein tyrosine phosphatase, receptor type, G 0.337727
ZFAT zinc finger and AT hook domain containing 0.337681
ELMO1 engulfment and cell motility 1 0.337635
E2F1 E2F transcription factor 1 0.33718
ERO1L ERO1-like (S. cerevisiae) 0.336051
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.335967
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.334639
GRM7 glutamate receptor, metabotropic 7 0.334561
KIF16B kinesin family member 16B 0.329009
HDAC4 histone deacetylase 4 0.328787
PCDH15 protocadherin-related 15 0.328192
KCNK2 potassium channel, two pore domain subfamily K, member 2 0.326427
LST1 leukocyte specific transcript 1 0.325978
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 0.323678
CLEC4M C-type lectin domain family 4, member M 0.32186
STK4 serine/threonine kinase 4 0.321619
KIFC3 kinesin family member C3 0.320482