sjogren's syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A hypersensitivity reaction type II disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva. (Human Disease Ontology, DOID_12894)
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Genes

176 genes co-occuring with the disease sjogren's syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
TRIM21 tripartite motif containing 21 1.81736
TROVE2 TROVE domain family, member 2 1.66555
HSPG2 heparan sulfate proteoglycan 2 1.55956
SSB Sjogren syndrome antigen B (autoantigen La) 1.30183
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 1.25689
CD79A CD79a molecule, immunoglobulin-associated alpha 1.25384
BPIFA2 BPI fold containing family A, member 2 1.21998
AQP5 aquaporin 5 1.10175
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.982636
CXCL13 chemokine (C-X-C motif) ligand 13 0.978006
CD4 CD4 molecule 0.974221
GOLIM4 golgi integral membrane protein 4 0.964567
AQP4 aquaporin 4 0.958287
LYZ lysozyme 0.946186
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.90732
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.893359
KLK13 kallikrein-related peptidase 13 0.804026
STAT4 signal transducer and activator of transcription 4 0.789262
FAM167A family with sequence similarity 167, member A 0.770027
B2M beta-2-microglobulin 0.759824
CXCR3 chemokine (C-X-C motif) receptor 3 0.707961
LTF lactotransferrin 0.661594
RPS20 ribosomal protein S20 0.634349
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase 0.632384
RBM14 RNA binding motif protein 14 0.618268
CA2 carbonic anhydrase II 0.618268
CXCL10 chemokine (C-X-C motif) ligand 10 0.614747
VARS valyl-tRNA synthetase 0.614747
NCR3 natural cytotoxicity triggering receptor 3 0.612401
SLC25A30 solute carrier family 25, member 30 0.609276
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.593674
NUMA1 nuclear mitotic apparatus protein 1 0.589001
CXCR5 chemokine (C-X-C motif) receptor 5 0.577327
SSRP1 structure specific recognition protein 1 0.575383
CENPH centromere protein H 0.565666
ALPPL2 alkaline phosphatase, placental-like 2 0.557509
ALPP alkaline phosphatase, placental 0.55712
ALPL alkaline phosphatase, liver/bone/kidney 0.556344
CA6 carbonic anhydrase VI 0.550911
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.550522
CENPC centromere protein C 0.541217
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.537731
CENPB centromere protein B, 80kDa 0.537731
BLK BLK proto-oncogene, Src family tyrosine kinase 0.533861
CCL19 chemokine (C-C motif) ligand 19 0.531928
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 0.531541
CLDN1 claudin 1 0.527676
MALT1 MALT1 paracaspase 0.518034
MUC16 mucin 16, cell surface associated 0.513802
CRP C-reactive protein, pentraxin-related 0.513033
CALR calreticulin 0.491215
TNF tumor necrosis factor 0.48893
STIM2 stromal interaction molecule 2 0.487788
PXK PX domain containing serine/threonine kinase 0.481705
PHRF1 PHD and ring finger domains 1 0.481325
LY9 lymphocyte antigen 9 0.474877
FAM3B family with sequence similarity 3, member B 0.474119
CCL21 chemokine (C-C motif) ligand 21 0.469197
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.467306
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.465038
WAC WW domain containing adaptor with coiled-coil 0.464283
SARDH sarcosine dehydrogenase 0.45447
CD19 CD19 molecule 0.448817
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.436402
BANK1 B-cell scaffold protein with ankyrin repeats 1 0.433772
VIP vasoactive intestinal peptide 0.433772
HMCN1 hemicentin 1 0.43227
IL2RA interleukin 2 receptor, alpha 0.425139
PRDX6 peroxiredoxin 6 0.422515
TRIM27 tripartite motif containing 27 0.414276
USO1 USO1 vesicle transport factor 0.413153
FEZF1 FEZ family zinc finger 1 0.407919
HNRNPL heterogeneous nuclear ribonucleoprotein L 0.407919
AICDA activation-induced cytidine deaminase 0.407919
CTSB cathepsin B 0.407172
FEZF2 FEZ family zinc finger 2 0.397098
CLDN2 claudin 2 0.392629
ERV3-1 endogenous retrovirus group 3, member 1 0.388909
RAB5A RAB5A, member RAS oncogene family 0.382223
FASLG Fas ligand (TNF superfamily, member 6) 0.381481
CD40 CD40 molecule, TNF receptor superfamily member 5 0.377031
TRIM5 tripartite motif containing 5 0.373328
BIRC3 baculoviral IAP repeat containing 3 0.372587
TGM4 transglutaminase 4 0.371847
IGHV3-9 immunoglobulin heavy variable 3-9 0.365562
CLDN7 claudin 7 0.364085
ALB albumin 0.364085
RPL22 ribosomal protein L22 0.359657
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 0.355972
BMF Bcl2 modifying factor 0.354868
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.340539
IRF7 interferon regulatory factor 7 0.336144
TLX1 T-cell leukemia homeobox 1 0.335412
APOH apolipoprotein H (beta-2-glycoprotein I) 0.332121
MUC1 mucin 1, cell surface associated 0.32993
IFNA1 interferon, alpha 1 0.3292
PRTN3 proteinase 3 0.324823
CLN3 ceroid-lipofuscinosis, neuronal 3 0.316092
SELL selectin L 0.307757
MMP9 matrix metallopeptidase 9 0.301254
ACTA1 actin, alpha 1, skeletal muscle 0.299812
PRL prolactin 0.295132
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 0.290821
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.290462
IFI16 interferon, gamma-inducible protein 16 0.281868
OCLN occludin 0.279011
WDR11 WD repeat domain 11 0.278654
CD27 CD27 molecule 0.27794
TJP1 tight junction protein 1 0.27794
KEAP1 kelch-like ECH-associated protein 1 0.275089
SNRPA small nuclear ribonucleoprotein polypeptide A 0.267267
CD5 CD5 molecule 0.265849
APITD1 apoptosis-inducing, TAF9-like domain 1 0.263014
HECA headcase homolog (Drosophila) 0.260184
LTB lymphotoxin beta (TNF superfamily, member 3) 0.259477
OSMR oncostatin M receptor 0.257711
HLA-B major histocompatibility complex, class I, B 0.257005
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 0.255594
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 0.253127
PCNA proliferating cell nuclear antigen 0.252774
KLK1 kallikrein 1 0.252422
BTLA B and T lymphocyte associated 0.251718
CD72 CD72 molecule 0.250663
MUC7 mucin 7, secreted 0.248905
RNASEH2A ribonuclease H2, subunit A 0.248554
WDFY2 WD repeat and FYVE domain containing 2 0.247852
HLA-A major histocompatibility complex, class I, A 0.232836
IFI44L interferon-induced protein 44-like 0.229716
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.229716
TNXB tenascin XB 0.228333
MYRF myelin regulatory factor 0.227988
MX1 MX dynamin-like GTPase 1 0.226262
HLA-C major histocompatibility complex, class I, C 0.225573
SH2D1A SH2 domain containing 1A 0.22454
MIP major intrinsic protein of lens fiber 0.224196
BCL6 B-cell CLL/lymphoma 6 0.222136
TNXA tenascin XA (pseudogene) 0.221793
BPGM 2,3-bisphosphoglycerate mutase 0.22145
RING1 ring finger protein 1 0.220766
CD40LG CD40 ligand 0.21974
PGAM2 phosphoglycerate mutase 2 (muscle) 0.219057
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 0.211261
RSPO1 R-spondin 1 0.207912
SIGLEC10 sialic acid binding Ig-like lectin 10 0.207578
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.20658
F11R F11 receptor 0.203275
CD58 CD58 molecule 0.202618
NPS neuropeptide S 0.201962
IRF1 interferon regulatory factor 1 0.196459
TGFB1 transforming growth factor, beta 1 0.195183
OR13F1 olfactory receptor, family 13, subfamily F, member 1 0.193285
F2 coagulation factor II (thrombin) 0.193285
ACRV1 acrosomal vesicle protein 1 0.192971
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 0.191719
IL1B interleukin 1, beta 0.191408
GSN gelsolin 0.190168
IFI44 interferon-induced protein 44 0.189859
ACP1 acid phosphatase 1, soluble 0.187719
NT5C 5', 3'-nucleotidase, cytosolic 0.187415
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.187113
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 0.18621
DUT deoxyuridine triphosphatase 0.185016
IL4 interleukin 4 0.179239
NELFCD negative elongation factor complex member C/D 0.178403
ICAM1 intercellular adhesion molecule 1 0.177851
B3GAT1 beta-1,3-glucuronyltransferase 1 0.176757
CD3D CD3d molecule, delta (CD3-TCR complex) 0.175411
DCD dermcidin 0.173057
PGAM1 phosphoglycerate mutase 1 (brain) 0.172038
IL6 interleukin 6 0.169091
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.168617
IL18BP interleukin 18 binding protein 0.167915
LAMB2 laminin, beta 2 (laminin S) 0.165435
PSIP1 PC4 and SFRS1 interacting protein 1 0.164149
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.163317
VIPR1 vasoactive intestinal peptide receptor 1 0.160948