sitosterol-4154 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the sitosterol-4154 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACSM5 acyl-CoA synthetase medium-chain family member 5
AK2 adenylate kinase 2
ANK2 ankyrin 2, neuronal
ATP10B ATPase, class V, type 10B
BTN2A3P butyrophilin, subfamily 2, member A3, pseudogene
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC81 coiled-coil domain containing 81
CCL27 chemokine (C-C motif) ligand 27
CFDP1 craniofacial development protein 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRLF2 cytokine receptor-like factor 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYTH4 cytohesin 4
DMRT1 doublesex and mab-3 related transcription factor 1
DOCK6 dedicator of cytokinesis 6
DPF1 D4, zinc and double PHD fingers family 1
DTNB dystrobrevin, beta
DVL2 dishevelled segment polarity protein 2
EDA ectodysplasin A
EGR2 early growth response 2
ELF5 E74-like factor 5 (ets domain transcription factor)
ELL2 elongation factor, RNA polymerase II, 2
EPYC epiphycan
FCMR Fc fragment of IgM receptor
FGF6 fibroblast growth factor 6
FLOT1 flotillin 1
FOXG1 forkhead box G1
GBP1 guanylate binding protein 1, interferon-inducible
GHRHR growth hormone releasing hormone receptor
GLB1L galactosidase, beta 1-like
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GRIP2 glutamate receptor interacting protein 2
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFNW1 interferon, omega 1
JMJD6 jumonji domain containing 6
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KLK7 kallikrein-related peptidase 7
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT17 keratin 17, type I
KRT32 keratin 32, type I
LAMB4 laminin, beta 4
LRRC37A3 leucine rich repeat containing 37, member A3
MAOA monoamine oxidase A
MAPK11 mitogen-activated protein kinase 11
MAPK7 mitogen-activated protein kinase 7
MCTP1 multiple C2 domains, transmembrane 1
MED18 mediator complex subunit 18
MID1 midline 1
MIP major intrinsic protein of lens fiber
MXD4 MAX dimerization protein 4
MYO1B myosin IB
NPR1 natriuretic peptide receptor 1
NR2E3 nuclear receptor subfamily 2, group E, member 3
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OMD osteomodulin
OR1G1 olfactory receptor, family 1, subfamily G, member 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PADI3 peptidyl arginine deiminase, type III
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARVB parvin, beta
PKN2 protein kinase N2
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLK3 polo-like kinase 3
PPP1R37 protein phosphatase 1, regulatory subunit 37
PRPH2 peripherin 2 (retinal degeneration, slow)
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
RABGAP1 RAB GTPase activating protein 1
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RIMS3 regulating synaptic membrane exocytosis 3
RPL10 ribosomal protein L10
RUNX1 runt-related transcription factor 1
SBNO1 strawberry notch homolog 1 (Drosophila)
SCN5A sodium channel, voltage gated, type V alpha subunit
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SH3GL3 SH3-domain GRB2-like 3
SLC16A4 solute carrier family 16, member 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNED1 sushi, nidogen and EGF-like domains 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
TAAR5 trace amine associated receptor 5
TEP1 telomerase-associated protein 1
THBS1 thrombospondin 1
THRB thyroid hormone receptor, beta
TPSG1 tryptase gamma 1
TTC39A tetratricopeptide repeat domain 39A
USP22 ubiquitin specific peptidase 22
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBTB43 zinc finger and BTB domain containing 43
ZNF407 zinc finger protein 407
ZNF652 zinc finger protein 652
ZNF702P zinc finger protein 702, pseudogene
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACAD10 acyl-CoA dehydrogenase family, member 10
ACTL8 actin-like 8
ADCK4 aarF domain containing kinase 4
AFAP1 actin filament associated protein 1
AGMAT agmatine ureohydrolase (agmatinase)
ALS2CL ALS2 C-terminal like
AMT aminomethyltransferase
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARMC4 armadillo repeat containing 4
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
BCL9 B-cell CLL/lymphoma 9
BHLHE41 basic helix-loop-helix family, member e41
C11ORF80 chromosome 11 open reading frame 80
C17ORF53 chromosome 17 open reading frame 53
C1QTNF3 C1q and tumor necrosis factor related protein 3
CA5BP1 carbonic anhydrase VB pseudogene 1
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAMTA1 calmodulin binding transcription activator 1
CCDC121 coiled-coil domain containing 121
CCDC68 coiled-coil domain containing 68
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CLDND1 claudin domain containing 1
CUL9 cullin 9
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DBF4B DBF4 zinc finger B
ENO3 enolase 3 (beta, muscle)
FAM186A family with sequence similarity 186, member A
FBXO2 F-box protein 2
FILIP1L filamin A interacting protein 1-like
FKBP10 FK506 binding protein 10, 65 kDa
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GEMIN8 gem (nuclear organelle) associated protein 8
GPR157 G protein-coupled receptor 157
GPRC5D G protein-coupled receptor, class C, group 5, member D
GRPR gastrin-releasing peptide receptor
HDAC11 histone deacetylase 11
HIST1H2AI histone cluster 1, H2ai
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HYI hydroxypyruvate isomerase (putative)
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIAA0754 KIAA0754
KLF3 Kruppel-like factor 3 (basic)
LHX1 LIM homeobox 1
LOC257152 uncharacterized LOC257152
LRRC61 leucine rich repeat containing 61
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MCOLN1 mucolipin 1
MDM4 MDM4, p53 regulator
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
NDE1 nudE neurodevelopment protein 1
NDOR1 NADPH dependent diflavin oxidoreductase 1
NECAP2 NECAP endocytosis associated 2
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PADI1 peptidyl arginine deiminase, type I
PARG poly (ADP-ribose) glycohydrolase
PCDHB3 protocadherin beta 3
PGPEP1 pyroglutamyl-peptidase I
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
POMT2 protein-O-mannosyltransferase 2
POPDC3 popeye domain containing 3
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PXN paxillin
RNF39 ring finger protein 39
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPAP1 RNA polymerase II associated protein 1
SETD8 SET domain containing (lysine methyltransferase) 8
SIX1 SIX homeobox 1
SKI SKI proto-oncogene
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLMO1 slowmo homolog 1 (Drosophila)
SPINK4 serine peptidase inhibitor, Kazal type 4
STK16 serine/threonine kinase 16
SYNC syncoilin, intermediate filament protein
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TET3 tet methylcytosine dioxygenase 3
THBS3 thrombospondin 3
TNRC6B trinucleotide repeat containing 6B
TPCN1 two pore segment channel 1
TRAIP TRAF interacting protein
UPK3B uroplakin 3B
VGF VGF nerve growth factor inducible
WDR33 WD repeat domain 33
WDR4 WD repeat domain 4
XYLT2 xylosyltransferase II
ZBTB6 zinc finger and BTB domain containing 6
ZNF532 zinc finger protein 532
ZNF580 zinc finger protein 580
ZNF750 zinc finger protein 750
ZSWIM1 zinc finger, SWIM-type containing 1