site of double-strand break Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. (Gene Ontology, GO_0035861)
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Genes

88 proteins co-occuring with the site of double-strand break cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
H2AFX H2A histone family, member X 1.99405
ATM ATM serine/threonine kinase 1.83543
MDC1 mediator of DNA-damage checkpoint 1 1.77275
UIMC1 ubiquitin interaction motif containing 1 1.65513
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 1.59778
BRCA1 breast cancer 1, early onset 1.5514
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 1.42429
RAD51 RAD51 recombinase 1.37409
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 1.33033
CHEK1 checkpoint kinase 1 0.980016
ZNF668 zinc finger protein 668 0.951619
RAD50 RAD50 homolog (S. cerevisiae) 0.940689
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.852961
BARD1 BRCA1 associated RING domain 1 0.768171
INTS3 integrator complex subunit 3 0.750904
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.749999
UBA6 ubiquitin-like modifier activating enzyme 6 0.733768
INIP INTS3 and NABP interacting protein 0.728389
MCPH1 microcephalin 1 0.723472
UBE2N ubiquitin-conjugating enzyme E2N 0.716346
TP53 tumor protein p53 0.697344
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.695587
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.679849
WRN Werner syndrome, RecQ helicase-like 0.650869
ATRIP ATR interacting protein 0.600644
RAD52 RAD52 homolog (S. cerevisiae) 0.594753
ELF4 E74-like factor 4 (ets domain transcription factor) 0.593912
TGM6 transglutaminase 6 0.593072
BRCA2 breast cancer 2, early onset 0.563017
TOPBP1 topoisomerase (DNA) II binding protein 1 0.530847
FANCD2 Fanconi anemia, complementation group D2 0.525113
TP53BP1 tumor protein p53 binding protein 1 0.521023
NBN nibrin 0.518573
RECQL4 RecQ protein-like 4 0.518165
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.499447
KAT8 K(lysine) acetyltransferase 8 0.490135
TERF2 telomeric repeat binding factor 2 0.484886
UBD ubiquitin D 0.479647
FAN1 FANCD2/FANCI-associated nuclease 1 0.452825
SENP6 SUMO1/sentrin specific peptidase 6 0.438542
RBBP8 retinoblastoma binding protein 8 0.421604
PHF13 PHD finger protein 13 0.41143
NABP2 nucleic acid binding protein 2 0.410259
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.382354
NUSAP1 nucleolar and spindle associated protein 1 0.381199
PRMT1 protein arginine methyltransferase 1 0.37045
RAD9A RAD9 homolog A (S. pombe) 0.360896
HINT1 histidine triad nucleotide binding protein 1 0.357847
CDKN2A cyclin-dependent kinase inhibitor 2A 0.354422
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 0.354042
TADA3 transcriptional adaptor 3 0.352901
TPX2 TPX2, microtubule-associated 0.334733
RECQL5 RecQ protein-like 5 0.330213
PSPC1 paraspeckle component 1 0.328708
NTHL1 nth endonuclease III-like 1 (E. coli) 0.3227
POT1 protection of telomeres 1 0.320451
STAT5A signal transducer and activator of transcription 5A 0.319328
VRK1 vaccinia related kinase 1 0.314465
HIST2H2AC histone cluster 2, H2ac 0.313344
HIST2H2AA3 histone cluster 2, H2aa3 0.312971
HIST2H2AA4 histone cluster 2, H2aa4 0.312971
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.309986
SUMO3 small ubiquitin-like modifier 3 0.300311
RNF2 ring finger protein 2 0.296601
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.292527
SUMO2 small ubiquitin-like modifier 2 0.284769
GADD45A growth arrest and DNA-damage-inducible, alpha 0.273
RECQL RecQ helicase-like 0.270434
MRC1 mannose receptor, C type 1 0.261296
SLX4 SLX4 structure-specific endonuclease subunit 0.257652
KIF15 kinesin family member 15 0.234533
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.230958
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 0.223143
BID BH3 interacting domain death agonist 0.218212
PARK2 parkin RBR E3 ubiquitin protein ligase 0.211933
BMI1 BMI1 proto-oncogene, polycomb ring finger 0.210203
FANCF Fanconi anemia, complementation group F 0.209513
DDB2 damage-specific DNA binding protein 2, 48kDa 0.209169
MAPK14 mitogen-activated protein kinase 14 0.198325
PIAS4 protein inhibitor of activated STAT, 4 0.191135
KIFC1 kinesin family member C1 0.186708
TRIM28 tripartite motif containing 28 0.185469
EPN1 epsin 1 0.181524
CUX1 cut-like homeobox 1 0.168598
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.168349
PIAS1 protein inhibitor of activated STAT, 1 0.164089
HMX1 H6 family homeobox 1 0.162117
FANCI Fanconi anemia, complementation group I 0.158502