sisomicin-4132 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the sisomicin-4132 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ACO2 aconitase 2, mitochondrial
ADAM20 ADAM metallopeptidase domain 20
ADAM22 ADAM metallopeptidase domain 22
ADRA1A adrenoceptor alpha 1A
AFF1 AF4/FMR2 family, member 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AQP4 aquaporin 4
ATXN2L ataxin 2-like
BICC1 BicC family RNA binding protein 1
CA9 carbonic anhydrase IX
CADM4 cell adhesion molecule 4
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC40 coiled-coil domain containing 40
CD160 CD160 molecule
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
COL1A1 collagen, type I, alpha 1
CRY2 cryptochrome circadian clock 2
CSHL1 chorionic somatomammotropin hormone-like 1
CYTH4 cytohesin 4
DCTN2 dynactin 2 (p50)
DIAPH2-AS1 DIAPH2 antisense RNA 1
DLK2 delta-like 2 homolog (Drosophila)
DYM dymeclin
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ELL2 elongation factor, RNA polymerase II, 2
FAM212B family with sequence similarity 212, member B
FBLN1 fibulin 1
FBXO40 F-box protein 40
GGT1 gamma-glutamyltransferase 1
GPR22 G protein-coupled receptor 22
GPR85 G protein-coupled receptor 85
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HFE hemochromatosis
HIST1H3E histone cluster 1, H3e
HIST1H3I histone cluster 1, H3i
HOXB5 homeobox B5
ICAM1 intercellular adhesion molecule 1
ICOSLG inducible T-cell co-stimulator ligand
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB6 integrin, beta 6
JAM3 junctional adhesion molecule 3
KIF21B kinesin family member 21B
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLF12 Kruppel-like factor 12
LAMB4 laminin, beta 4
LGALS8 lectin, galactoside-binding, soluble, 8
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LPAR1 lysophosphatidic acid receptor 1
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAL mal, T-cell differentiation protein
METTL7A methyltransferase like 7A
NDN necdin, melanoma antigen (MAGE) family member
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NTM neurotrimin
OCM2 oncomodulin 2
OR10H3 olfactory receptor, family 10, subfamily H, member 3
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARG poly (ADP-ribose) glycohydrolase
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PLEK pleckstrin
POLM polymerase (DNA directed), mu
PRKG2 protein kinase, cGMP-dependent, type II
PTAFR platelet-activating factor receptor
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RBMS3 RNA binding motif, single stranded interacting protein 3
REPS1 RALBP1 associated Eps domain containing 1
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RSU1 Ras suppressor protein 1
SAG S-antigen; retina and pineal gland (arrestin)
SH2D2A SH2 domain containing 2A
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SSTR2 somatostatin receptor 2
TBX5 T-box 5
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TG thyroglobulin
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TP53I11 tumor protein p53 inducible protein 11
TP63 tumor protein p63
TRD T cell receptor delta locus
TRIM68 tripartite motif containing 68
TSPAN9 tetraspanin 9
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
ZFYVE9 zinc finger, FYVE domain containing 9
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF155 zinc finger protein 155

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACTL8 actin-like 8
APOD apolipoprotein D
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARID3B AT rich interactive domain 3B (BRIGHT-like)
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B9D2 B9 protein domain 2
BAHCC1 BAH domain and coiled-coil containing 1
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C11ORF30 chromosome 11 open reading frame 30
C11ORF63 chromosome 11 open reading frame 63
C5AR1 complement component 5a receptor 1
CCDC132 coiled-coil domain containing 132
CCDC69 coiled-coil domain containing 69
CD53 CD53 molecule
CD82 CD82 molecule
CEL carboxyl ester lipase
CLCA1 chloride channel accessory 1
CLCF1 cardiotrophin-like cytokine factor 1
CLIP4 CAP-GLY domain containing linker protein family, member 4
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DGAT1 diacylglycerol O-acyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSPP dentin sialophosphoprotein
DYSF dysferlin
EHBP1L1 EH domain binding protein 1-like 1
ENO2 enolase 2 (gamma, neuronal)
EPX eosinophil peroxidase
FADS2 fatty acid desaturase 2
FAM46C family with sequence similarity 46, member C
FBXO31 F-box protein 31
FGF13 fibroblast growth factor 13
FLJ21369 uncharacterized protein FLJ21369
FMOD fibromodulin
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
GBP2 guanylate binding protein 2, interferon-inducible
GPR19 G protein-coupled receptor 19
HCFC1 host cell factor C1
HIST1H2AK histone cluster 1, H2ak
HMOX1 heme oxygenase 1
IL4R interleukin 4 receptor
INO80D INO80 complex subunit D
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IQSEC2 IQ motif and Sec7 domain 2
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCTD7 potassium channel tetramerization domain containing 7
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF1 Kruppel-like factor 1 (erythroid)
KLHL25 kelch-like family member 25
LAMP3 lysosomal-associated membrane protein 3
LEFTY1 left-right determination factor 1
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAST3 microtubule associated serine/threonine kinase 3
MGC2889 uncharacterized protein MGC2889
MOCS3 molybdenum cofactor synthesis 3
MST1 macrophage stimulating 1
NEUROD4 neuronal differentiation 4
NIPAL2 NIPA-like domain containing 2
NME5 NME/NM23 family member 5
PCBP4 poly(rC) binding protein 4
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLD3 phospholipase D family, member 3
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PTPRM protein tyrosine phosphatase, receptor type, M
PXN paxillin
RAB36 RAB36, member RAS oncogene family
RHBDD3 rhomboid domain containing 3
RPL13P5 ribosomal protein L13 pseudogene 5
SCN1B sodium channel, voltage gated, type I beta subunit
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGK2 serum/glucocorticoid regulated kinase 2
SLC12A9 solute carrier family 12, member 9
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
TBC1D19 TBC1 domain family, member 19
TBX19 T-box 19
TCP10 t-complex 10
TLR5 toll-like receptor 5
TMEM180 transmembrane protein 180
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSNAXIP1 translin-associated factor X interacting protein 1
UBQLN4 ubiquilin 4
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VEGFB vascular endothelial growth factor B
VIM vimentin
VWA1 von Willebrand factor A domain containing 1
ZNF230 zinc finger protein 230
ZNF329 zinc finger protein 329
ZNF34 zinc finger protein 34