sirolimus-987 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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200 genes differentially expressed following the sirolimus-987 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADRA1D adrenoceptor alpha 1D
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
AOAH acyloxyacyl hydrolase (neutrophil)
APOL2 apolipoprotein L, 2
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ATP11A ATPase, class VI, type 11A
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
ATXN3 ataxin 3
BIN1 bridging integrator 1
CASS4 Cas scaffolding protein family member 4
CCDC85B coiled-coil domain containing 85B
CD6 CD6 molecule
CD82 CD82 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDHR2 cadherin-related family member 2
CNN1 calponin 1, basic, smooth muscle
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL1A1 collagen, type I, alpha 1
COL9A3 collagen, type IX, alpha 3
CSHL1 chorionic somatomammotropin hormone-like 1
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DBF4B DBF4 zinc finger B
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DLX5 distal-less homeobox 5
EGR1 early growth response 1
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FABP6 fatty acid binding protein 6, ileal
FAM13C family with sequence similarity 13, member C
FAM155A family with sequence similarity 155, member A
FAM214B family with sequence similarity 214, member B
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
HABP4 hyaluronan binding protein 4
HEG1 heart development protein with EGF-like domains 1
HIST1H2AI histone cluster 1, H2ai
HLA-F major histocompatibility complex, class I, F
HRG histidine-rich glycoprotein
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IBSP integrin-binding sialoprotein
IGKV3-20 immunoglobulin kappa variable 3-20
JAG1 jagged 1
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLHL22 kelch-like family member 22
KLHL24 kelch-like family member 24
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LIME1 Lck interacting transmembrane adaptor 1
LOC100129648 uncharacterized LOC100129648
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK10 mitogen-activated protein kinase 10
MED15 mediator complex subunit 15
MMP1 matrix metallopeptidase 1
MTSS1L metastasis suppressor 1-like
MVP major vault protein
NACA2 nascent polypeptide-associated complex alpha subunit 2
NHLH2 nescient helix loop helix 2
PARP11 poly (ADP-ribose) polymerase family, member 11
PCDHB17P protocadherin beta 17 pseudogene
PCNX pecanex homolog (Drosophila)
PDGFB platelet-derived growth factor beta polypeptide
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLIN2 perilipin 2
PPARA peroxisome proliferator-activated receptor alpha
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRLR prolactin receptor
PRPF18 pre-mRNA processing factor 18
PRSS53 protease, serine, 53
RGS10 regulator of G-protein signaling 10
RGS12 regulator of G-protein signaling 12
RIN2 Ras and Rab interactor 2
RPL10 ribosomal protein L10
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUFY3 RUN and FYVE domain containing 3
SAMD9 sterile alpha motif domain containing 9
SCN1B sodium channel, voltage gated, type I beta subunit
SH3BP2 SH3-domain binding protein 2
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SPATA1 spermatogenesis associated 1
SPON2 spondin 2, extracellular matrix protein
SUGP1 SURP and G patch domain containing 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAOK1 TAO kinase 1
TIGD6 tigger transposable element derived 6
TMPRSS4 transmembrane protease, serine 4
TNS2 tensin 2
TPP1 tripeptidyl peptidase I
TRIM10 tripartite motif containing 10
TTLL5 tubulin tyrosine ligase-like family member 5
TXNIP thioredoxin interacting protein
WIZ widely interspaced zinc finger motifs
ZNF45 zinc finger protein 45
ZNF639 zinc finger protein 639
ZNF682 zinc finger protein 682
ZNF771 zinc finger protein 771
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AEN apoptosis enhancing nuclease
AKAP12 A kinase (PRKA) anchor protein 12
ANP32A-IT1 ANP32A intronic transcript 1
ARHGAP10 Rho GTPase activating protein 10
ASB6 ankyrin repeat and SOCS box containing 6
BBS7 Bardet-Biedl syndrome 7
C17ORF70 chromosome 17 open reading frame 70
C19ORF24 chromosome 19 open reading frame 24
C9ORF91 chromosome 9 open reading frame 91
CCDC86 coiled-coil domain containing 86
CCNE1 cyclin E1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHKB choline kinase beta
CUL1 cullin 1
DDIT3 DNA-damage-inducible transcript 3
EFHD2 EF-hand domain family, member D2
EGLN3 egl-9 family hypoxia-inducible factor 3
EHD3 EH-domain containing 3
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
EPS8L2 EPS8-like 2
ETAA1 Ewing tumor-associated antigen 1
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
GLCE glucuronic acid epimerase
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
HAUS6 HAUS augmin-like complex, subunit 6
HCFC2 host cell factor C2
HEATR3 HEAT repeat containing 3
HHEX hematopoietically expressed homeobox
HIRA histone cell cycle regulator
HPS5 Hermansky-Pudlak syndrome 5
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IFRD1 interferon-related developmental regulator 1
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
KLHL2 kelch-like family member 2
LIG4 ligase IV, DNA, ATP-dependent
LYRM2 LYR motif containing 2
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAPK12 mitogen-activated protein kinase 12
MDM4 MDM4, p53 regulator
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MNS1 meiosis-specific nuclear structural 1
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOTCH1 notch 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NRBF2 nuclear receptor binding factor 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDZRN3 PDZ domain containing ring finger 3
POLH polymerase (DNA directed), eta
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PSKH1 protein serine kinase H1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PTPRU protein tyrosine phosphatase, receptor type, U
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RASA2 RAS p21 protein activator 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBL1 retinoblastoma-like 1
RBM38 RNA binding motif protein 38
RGS19 regulator of G-protein signaling 19
RNF25 ring finger protein 25
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RP2 retinitis pigmentosa 2 (X-linked recessive)
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCO2 SCO2 cytochrome c oxidase assembly protein
SHARPIN SHANK-associated RH domain interactor
SKA1 spindle and kinetochore associated complex subunit 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPIDR scaffolding protein involved in DNA repair
SSFA2 sperm specific antigen 2
STK25 serine/threonine kinase 25
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
SURF2 surfeit 2
SUSD4 sushi domain containing 4
TGDS TDP-glucose 4,6-dehydratase
THOC1 THO complex 1
THOP1 thimet oligopeptidase 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM183A transmembrane protein 183A
TPRA1 transmembrane protein, adipocyte asscociated 1
TPST1 tyrosylprotein sulfotransferase 1
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
WDR18 WD repeat domain 18
WDR76 WD repeat domain 76
ZMAT5 zinc finger, matrin-type 5
ZNF408 zinc finger protein 408
ZNF473 zinc finger protein 473
ZNF492 zinc finger protein 492
ZNF721 zinc finger protein 721
ZNF778 zinc finger protein 778