sirolimus-921 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the sirolimus-921 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRE2 adhesion G protein-coupled receptor E2
AHNAK2 AHNAK nucleoprotein 2
AKAP13 A kinase (PRKA) anchor protein 13
AKAP7 A kinase (PRKA) anchor protein 7
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APOE apolipoprotein E
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARL4C ADP-ribosylation factor-like 4C
ASB1 ankyrin repeat and SOCS box containing 1
C14ORF79 chromosome 14 open reading frame 79
CA4 carbonic anhydrase IV
CALD1 caldesmon 1
CCDC132 coiled-coil domain containing 132
CD52 CD52 molecule
CD96 CD96 molecule
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CENPQ centromere protein Q
COL1A1 collagen, type I, alpha 1
COL4A5 collagen, type IV, alpha 5
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRELD1 cysteine-rich with EGF-like domains 1
CTSF cathepsin F
CTTN cortactin
CUL9 cullin 9
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DBT dihydrolipoamide branched chain transacylase E2
DUSP4 dual specificity phosphatase 4
DZIP3 DAZ interacting zinc finger protein 3
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHB2 EPH receptor B2
EPHX2 epoxide hydrolase 2, cytoplasmic
EXTL3 exostosin-like glycosyltransferase 3
FBXL2 F-box and leucine-rich repeat protein 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GPATCH2L G patch domain containing 2-like
GREB1L growth regulation by estrogen in breast cancer-like
GSTA3 glutathione S-transferase alpha 3
HFE hemochromatosis
HSPB11 heat shock protein family B (small), member 11
HSPB6 heat shock protein, alpha-crystallin-related, B6
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
INO80B INO80 complex subunit B
KIF25-AS1 KIF25 antisense RNA 1
KLF13 Kruppel-like factor 13
KLHL23 kelch-like family member 23
KLHL24 kelch-like family member 24
KLHL28 kelch-like family member 28
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LOC644450 uncharacterized LOC644450
LPXN leupaxin
MEP1B meprin A, beta
MST1 macrophage stimulating 1
MXD4 MAX dimerization protein 4
MYLK myosin light chain kinase
NEK9 NIMA-related kinase 9
NPFFR1 neuropeptide FF receptor 1
PADI3 peptidyl arginine deiminase, type III
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PPARD peroxisome proliferator-activated receptor delta
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRDX2 peroxiredoxin 2
PRKD3 protein kinase D3
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PTPRF protein tyrosine phosphatase, receptor type, F
RECQL5 RecQ protein-like 5
RGS6 regulator of G-protein signaling 6
RNF208 ring finger protein 208
RPL10 ribosomal protein L10
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RTN2 reticulon 2
SC5D sterol-C5-desaturase
SCUBE3 signal peptide, CUB domain, EGF-like 3
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SPATA5L1 spermatogenesis associated 5-like 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SPON2 spondin 2, extracellular matrix protein
SUGP1 SURP and G patch domain containing 1
SURF1 surfeit 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TDRD12 tudor domain containing 12
THBS3 thrombospondin 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM209 transmembrane protein 209
TRA2A transformer 2 alpha homolog (Drosophila)
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)
TUBA3C tubulin, alpha 3c
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
WDR1 WD repeat domain 1
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF451 zinc finger protein 451
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ARHGAP11A Rho GTPase activating protein 11A
ASPHD1 aspartate beta-hydroxylase domain containing 1
AVPI1 arginine vasopressin-induced 1
BBS7 Bardet-Biedl syndrome 7
BRAF B-Raf proto-oncogene, serine/threonine kinase
BYSL bystin-like
C19ORF40 chromosome 19 open reading frame 40
C6ORF47 chromosome 6 open reading frame 47
C7ORF43 chromosome 7 open reading frame 43
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCDC85C coiled-coil domain containing 85C
CDK20 cyclin-dependent kinase 20
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CORO1A coronin, actin binding protein, 1A
DDA1 DET1 and DDB1 associated 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DMTF1 cyclin D binding myb-like transcription factor 1
DNAAF2 dynein, axonemal, assembly factor 2
EAF2 ELL associated factor 2
EMC7 ER membrane protein complex subunit 7
ETAA1 Ewing tumor-associated antigen 1
FJX1 four jointed box 1 (Drosophila)
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPALPP1 GPALPP motifs containing 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HDAC4 histone deacetylase 4
HIST1H2AM histone cluster 1, H2am
HMHA1 histocompatibility (minor) HA-1
HSPA2 heat shock 70kDa protein 2
HYI hydroxypyruvate isomerase (putative)
IL17RA interleukin 17 receptor A
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
KATNBL1 katanin p80 subunit B-like 1
KCTD20 potassium channel tetramerization domain containing 20
KRT15 keratin 15, type I
L2HGDH L-2-hydroxyglutarate dehydrogenase
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK12 mitogen-activated protein kinase 12
MBTPS2 membrane-bound transcription factor peptidase, site 2
METTL8 methyltransferase like 8
MIR22HG MIR22 host gene
MMP9 matrix metallopeptidase 9
MORC3 MORC family CW-type zinc finger 3
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MRPL44 mitochondrial ribosomal protein L44
MTA2 metastasis associated 1 family, member 2
NFE2L3 nuclear factor, erythroid 2-like 3
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
P3H1 prolyl 3-hydroxylase 1
PCBP4 poly(rC) binding protein 4
PCDHB13 protocadherin beta 13
PDGFRL platelet-derived growth factor receptor-like
PDZRN3 PDZ domain containing ring finger 3
PGPEP1 pyroglutamyl-peptidase I
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G3 phospholipase A2, group III
PLD2 phospholipase D2
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POLH polymerase (DNA directed), eta
PPAN peter pan homolog (Drosophila)
PRICKLE3 prickle homolog 3 (Drosophila)
RAB33B RAB33B, member RAS oncogene family
RPL23AP7 ribosomal protein L23a pseudogene 7
RPP25 ribonuclease P/MRP 25kDa subunit
SAMD9 sterile alpha motif domain containing 9
SCAND1 SCAN domain containing 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH2B3 SH2B adaptor protein 3
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SRRD SRR1 domain containing
STIM1 stromal interaction molecule 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYBU syntabulin (syntaxin-interacting)
SYT17 synaptotagmin XVII
TMEM51 transmembrane protein 51
TMPRSS3 transmembrane protease, serine 3
TPST1 tyrosylprotein sulfotransferase 1
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
UBQLN4 ubiquilin 4
USB1 U6 snRNA biogenesis 1
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
WDR4 WD repeat domain 4
ZBTB22 zinc finger and BTB domain containing 22
ZBTB48 zinc finger and BTB domain containing 48
ZCCHC10 zinc finger, CCHC domain containing 10
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF268 zinc finger protein 268
ZNF34 zinc finger protein 34
ZNF35 zinc finger protein 35
ZNF552 zinc finger protein 552
ZNF76 zinc finger protein 76