sirolimus-6981 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the sirolimus-6981 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR2B activin A receptor, type IIB
ADARB1 adenosine deaminase, RNA-specific, B1
AKAP7 A kinase (PRKA) anchor protein 7
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMPD3 adenosine monophosphate deaminase 3
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASTN2 astrotactin 2
C14ORF93 chromosome 14 open reading frame 93
C1ORF54 chromosome 1 open reading frame 54
C2ORF54 chromosome 2 open reading frame 54
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC71 coiled-coil domain containing 71
CCDC87 coiled-coil domain containing 87
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CDADC1 cytidine and dCMP deaminase domain containing 1
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLCN7 chloride channel, voltage-sensitive 7
COL4A2 collagen, type IV, alpha 2
CPNE7 copine VII
CYLD cylindromatosis (turban tumor syndrome)
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DBN1 drebrin 1
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
EN1 engrailed homeobox 1
ENO2 enolase 2 (gamma, neuronal)
EPHA1 EPH receptor A1
FCRL2 Fc receptor-like 2
FECH ferrochelatase
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
GSAP gamma-secretase activating protein
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HFE hemochromatosis
HIPK3 homeodomain interacting protein kinase 3
HIST1H4A histone cluster 1, H4a
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL11 interleukin 11
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KIAA0355 KIAA0355
KIFC3 kinesin family member C3
KLHL24 kelch-like family member 24
LDHB lactate dehydrogenase B
LHX1 LIM homeobox 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPT microtubule-associated protein tau
MAST3 microtubule associated serine/threonine kinase 3
MAST4 microtubule associated serine/threonine kinase family member 4
MED9 mediator complex subunit 9
MFAP2 microfibrillar-associated protein 2
MXD4 MAX dimerization protein 4
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NRF1 nuclear respiratory factor 1
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
OCA2 oculocutaneous albinism II
PAQR6 progestin and adipoQ receptor family member VI
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHB3 protocadherin beta 3
PDE4C phosphodiesterase 4C, cAMP-specific
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PQBP1 polyglutamine binding protein 1
PROX1 prospero homeobox 1
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PTPRS protein tyrosine phosphatase, receptor type, S
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RECQL5 RecQ protein-like 5
RIN2 Ras and Rab interactor 2
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SFTPB surfactant protein B
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SSPN sarcospan
SYNJ2 synaptojanin 2
TCF12 transcription factor 12
TCP10L t-complex 10-like
TDRD1 tudor domain containing 1
TMC5 transmembrane channel-like 5
TMEM53 transmembrane protein 53
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TTLL1 tubulin tyrosine ligase-like family member 1
TXNIP thioredoxin interacting protein
UNC5B unc-5 homolog B (C. elegans)
ZNF16 zinc finger protein 16
ZNF384 zinc finger protein 384
ZNF419 zinc finger protein 419
ZNF549 zinc finger protein 549
ZNF747 zinc finger protein 747
ZNF783 zinc finger family member 783
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ANKRD10 ankyrin repeat domain 10
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGAP10 Rho GTPase activating protein 10
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATAD3A ATPase family, AAA domain containing 3A
ATAD5 ATPase family, AAA domain containing 5
BTF3P12 basic transcription factor 3 pseudogene 12
C19ORF40 chromosome 19 open reading frame 40
C21ORF91 chromosome 21 open reading frame 91
C5ORF28 chromosome 5 open reading frame 28
C5ORF45 chromosome 5 open reading frame 45
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBX4 chromobox homolog 4
CCDC86 coiled-coil domain containing 86
CCNJ cyclin J
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CENPJ centromere protein J
CEP72 centrosomal protein 72kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHUK conserved helix-loop-helix ubiquitous kinase
COG4 component of oligomeric golgi complex 4
CRY1 cryptochrome circadian clock 1
CTSK cathepsin K
DNAAF2 dynein, axonemal, assembly factor 2
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EPPK1 epiplakin 1
ERO1L ERO1-like (S. cerevisiae)
FOXJ2 forkhead box J2
GAB2 GRB2-associated binding protein 2
GAN gigaxonin
HCFC2 host cell factor C2
HOMER1 homer scaffolding protein 1
ICK intestinal cell (MAK-like) kinase
IFRD1 interferon-related developmental regulator 1
INF2 inverted formin, FH2 and WH2 domain containing
INPPL1 inositol polyphosphate phosphatase-like 1
JMJD4 jumonji domain containing 4
KATNBL1 katanin p80 subunit B-like 1
KIAA0753 KIAA0753
KIAA0895 KIAA0895
LMNB2 lamin B2
LOXL1 lysyl oxidase-like 1
LYPLA2P1 lysophospholipase II pseudogene 1
MAN2B2 mannosidase, alpha, class 2B, member 2
MFSD12 major facilitator superfamily domain containing 12
MGC12488
MIR22HG MIR22 host gene
MRPL52 mitochondrial ribosomal protein L52
MSX1 msh homeobox 1
MUM1 melanoma associated antigen (mutated) 1
NBEAL2 neurobeachin-like 2
NCAM2 neural cell adhesion molecule 2
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NOTCH1 notch 1
OTUD3 OTU deubiquitinase 3
PARD6A par-6 family cell polarity regulator alpha
PGP phosphoglycolate phosphatase
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
PROCR protein C receptor, endothelial
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAI14 retinoic acid induced 14
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RINT1 RAD50 interactor 1
RNF31 ring finger protein 31
RP2 retinitis pigmentosa 2 (X-linked recessive)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAMHD1 SAM domain and HD domain 1
SAV1 salvador family WW domain containing protein 1
SCAMP3 secretory carrier membrane protein 3
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
SLC25A44 solute carrier family 25, member 44
SLC35F2 solute carrier family 35, member F2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SPHK1 sphingosine kinase 1
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCTN2 tectonic family member 2
TESK1 testis-specific kinase 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THAP4 THAP domain containing 4
TPST1 tyrosylprotein sulfotransferase 1
TRIP10 thyroid hormone receptor interactor 10
TSPAN14 tetraspanin 14
TSSC4 tumor suppressing subtransferable candidate 4
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
UNC119 unc-119 homolog (C. elegans)
ZC3H3 zinc finger CCCH-type containing 3
ZDHHC13 zinc finger, DHHC-type containing 13
ZMYM1 zinc finger, MYM-type 1
ZNF107 zinc finger protein 107
ZNF350 zinc finger protein 350
ZNF408 zinc finger protein 408