sirolimus-6967 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the sirolimus-6967 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGMAT agmatine ureohydrolase (agmatinase)
ARL4D ADP-ribosylation factor-like 4D
AURKA aurora kinase A
BAHCC1 BAH domain and coiled-coil containing 1
BCL2 B-cell CLL/lymphoma 2
BCORL1 BCL6 corepressor-like 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CADM4 cell adhesion molecule 4
CCNG2 cyclin G2
CDC25C cell division cycle 25C
CDK12 cyclin-dependent kinase 12
CDK20 cyclin-dependent kinase 20
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CLDN15 claudin 15
CTNS cystinosin, lysosomal cystine transporter
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DHRS12 dehydrogenase/reductase (SDR family) member 12
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EFNA3 ephrin-A3
EGR1 early growth response 1
ESR1 estrogen receptor 1
ESRRA estrogen-related receptor alpha
FAM155A family with sequence similarity 155, member A
FASLG Fas ligand (TNF superfamily, member 6)
FILIP1L filamin A interacting protein 1-like
GAMT guanidinoacetate N-methyltransferase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPC4 glypican 4
GPR15 G protein-coupled receptor 15
GPR153 G protein-coupled receptor 153
GPR87 G protein-coupled receptor 87
HEG1 heart development protein with EGF-like domains 1
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
IGHA1 immunoglobulin heavy constant alpha 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
ITM2C integral membrane protein 2C
JRK Jrk homolog (mouse)
KDM5A lysine (K)-specific demethylase 5A
KIF5C kinesin family member 5C
KLHL24 kelch-like family member 24
LMCD1 LIM and cysteine-rich domains 1
LMNA lamin A/C
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MED12 mediator complex subunit 12
MKL1 megakaryoblastic leukemia (translocation) 1
MOB3B MOB kinase activator 3B
MR1 major histocompatibility complex, class I-related
MSL3 male-specific lethal 3 homolog (Drosophila)
MYH14 myosin, heavy chain 14, non-muscle
MYO15B myosin XVB
NDRG2 NDRG family member 2
NEURL1 neuralized E3 ubiquitin protein ligase 1
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PAQR6 progestin and adipoQ receptor family member VI
PCDHB3 protocadherin beta 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLK3 polo-like kinase 3
PNPLA6 patatin-like phospholipase domain containing 6
POPDC3 popeye domain containing 3
POU5F1B POU class 5 homeobox 1B
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS5 regulator of G-protein signaling 5
RNF122 ring finger protein 122
RNF170 ring finger protein 170
RNF19B ring finger protein 19B
RPS3A ribosomal protein S3A
RTEL1 regulator of telomere elongation helicase 1
RTN2 reticulon 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SH3D21 SH3 domain containing 21
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSPN sarcospan
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
TCEAL2 transcription elongation factor A (SII)-like 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TK2 thymidine kinase 2, mitochondrial
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TTLL1 tubulin tyrosine ligase-like family member 1
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
TXNIP thioredoxin interacting protein
VPRBP Vpr (HIV-1) binding protein
VPS9D1 VPS9 domain containing 1
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF571 zinc finger protein 571
ZNF580 zinc finger protein 580
ZNF589 zinc finger protein 589
ZNF606 zinc finger protein 606
ZNF750 zinc finger protein 750
ZSCAN26 zinc finger and SCAN domain containing 26

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACIN1 apoptotic chromatin condensation inducer 1
AKIP1 A kinase (PRKA) interacting protein 1
AP4M1 adaptor-related protein complex 4, mu 1 subunit
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARRB2 arrestin, beta 2
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAD2B ATPase family, AAA domain containing 2B
ATAD3A ATPase family, AAA domain containing 3A
ATF7IP2 activating transcription factor 7 interacting protein 2
AUNIP aurora kinase A and ninein interacting protein
BAK1 BCL2-antagonist/killer 1
BARD1 BRCA1 associated RING domain 1
BRIX1 BRX1, biogenesis of ribosomes
BRPF1 bromodomain and PHD finger containing, 1
C17ORF70 chromosome 17 open reading frame 70
C5ORF45 chromosome 5 open reading frame 45
CAPN15 calpain 15
CCDC85C coiled-coil domain containing 85C
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP7 charged multivesicular body protein 7
CHSY1 chondroitin sulfate synthase 1
COPS7B COP9 signalosome subunit 7B
DCP1A decapping mRNA 1A
DDIT3 DNA-damage-inducible transcript 3
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEAF1 DEAF1 transcription factor
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNAL4 dynein, axonemal, light chain 4
DTWD1 DTW domain containing 1
ELMO3 engulfment and cell motility 3
FAM57A family with sequence similarity 57, member A
FBXO31 F-box protein 31
FHOD1 formin homology 2 domain containing 1
FKBP10 FK506 binding protein 10, 65 kDa
FMO4 flavin containing monooxygenase 4
FOSL1 FOS-like antigen 1
FOXJ2 forkhead box J2
FRS2 fibroblast growth factor receptor substrate 2
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
GRAMD4 GRAM domain containing 4
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HAUS6 HAUS augmin-like complex, subunit 6
HMHA1 histocompatibility (minor) HA-1
IFRD1 interferon-related developmental regulator 1
IFT81 intraflagellar transport 81
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITPKC inositol-trisphosphate 3-kinase C
JMJD4 jumonji domain containing 4
KLC2 kinesin light chain 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LNPEP leucyl/cystinyl aminopeptidase
LRP5 low density lipoprotein receptor-related protein 5
MBOAT2 membrane bound O-acyltransferase domain containing 2
MEIS1 Meis homeobox 1
MFSD12 major facilitator superfamily domain containing 12
MICALL2 MICAL-like 2
MIR22HG MIR22 host gene
MOCS2 molybdenum cofactor synthesis 2
MSX1 msh homeobox 1
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NIP7 NIP7, nucleolar pre-rRNA processing protein
NPY5R neuropeptide Y receptor Y5
NR1H2 nuclear receptor subfamily 1, group H, member 2
ORC1 origin recognition complex, subunit 1
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
POMZP3 POM121 and ZP3 fusion
POR P450 (cytochrome) oxidoreductase
PPAN peter pan homolog (Drosophila)
PSPH phosphoserine phosphatase
PTCD1 pentatricopeptide repeat domain 1
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RBBP5 retinoblastoma binding protein 5
RBM38 RNA binding motif protein 38
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RPL13P5 ribosomal protein L13 pseudogene 5
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
S100A4 S100 calcium binding protein A4
SART1 squamous cell carcinoma antigen recognized by T cells
SERTAD3 SERTA domain containing 3
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNHG3 small nucleolar RNA host gene 3
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TGDS TDP-glucose 4,6-dehydratase
THAP4 THAP domain containing 4
TP53BP2 tumor protein p53 binding protein 2
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
UNKL unkempt family zinc finger-like
WDR44 WD repeat domain 44
WDR46 WD repeat domain 46
ZNF408 zinc finger protein 408
ZNF586 zinc finger protein 586