sirolimus-6180 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the sirolimus-6180 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADORA1 adenosine A1 receptor
AGRN agrin
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOE apolipoprotein E
ATP13A2 ATPase type 13A2
BAX BCL2-associated X protein
BCO1 beta-carotene oxygenase 1
BIRC3 baculoviral IAP repeat containing 3
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C16ORF70 chromosome 16 open reading frame 70
CCDC57 coiled-coil domain containing 57
CCL27 chemokine (C-C motif) ligand 27
CDK10 cyclin-dependent kinase 10
CFAP45 cilia and flagella associated protein 45
CGA glycoprotein hormones, alpha polypeptide
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLDN3 claudin 3
CNPY4 canopy FGF signaling regulator 4
CPT1A carnitine palmitoyltransferase 1A (liver)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DOCK6 dedicator of cytokinesis 6
ERC1 ELKS/RAB6-interacting/CAST family member 1
ESRRG estrogen-related receptor gamma
FBXO40 F-box protein 40
FER1L4 fer-1-like family member 4, pseudogene (functional)
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GOLGA2P5 golgin A2 pseudogene 5
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
HHLA1 HERV-H LTR-associating 1
HIRA histone cell cycle regulator
HSF1 heat shock transcription factor 1
ICAM5 intercellular adhesion molecule 5, telencephalin
ICK intestinal cell (MAK-like) kinase
IDS iduronate 2-sulfatase
IL22 interleukin 22
KIAA0319L KIAA0319-like
KIAA1456 KIAA1456
KIF1C kinesin family member 1C
KMT2A lysine (K)-specific methyltransferase 2A
MECOM MDS1 and EVI1 complex locus
MID1 midline 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MRPL41 mitochondrial ribosomal protein L41
MST1L macrophage stimulating 1-like
MTUS1 microtubule associated tumor suppressor 1
NAG18 NAG18 mRNA
NAP1L2 nucleosome assembly protein 1-like 2
NELL2 NEL-like 2 (chicken)
NPPA natriuretic peptide A
NUP88 nucleoporin 88kDa
OCM2 oncomodulin 2
OSBPL7 oxysterol binding protein-like 7
PADI1 peptidyl arginine deiminase, type I
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHGA3 protocadherin gamma subfamily A, 3
PCNXL2 pecanex-like 2 (Drosophila)
PEX26 peroxisomal biogenesis factor 26
PLA2G16 phospholipase A2, group XVI
PLA2G2E phospholipase A2, group IIE
PLCH1 phospholipase C, eta 1
PLD3 phospholipase D family, member 3
POU6F2 POU class 6 homeobox 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRDM12 PR domain containing 12
PTGDR2 prostaglandin D2 receptor 2
RASAL2 RAS protein activator like 2
RBM12B RNA binding motif protein 12B
REG1B regenerating islet-derived 1 beta
ROM1 retinal outer segment membrane protein 1
RPL10L ribosomal protein L10-like
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SEZ6L seizure related 6 homolog (mouse)-like
SH3BGR SH3 domain binding glutamate-rich protein
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SMG7 SMG7 nonsense mediated mRNA decay factor
SORBS3 sorbin and SH3 domain containing 3
SOSTDC1 sclerostin domain containing 1
SPHK1 sphingosine kinase 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SRRT serrate, RNA effector molecule
ST7L suppression of tumorigenicity 7 like
STAB2 stabilin 2
SYNE1 spectrin repeat containing, nuclear envelope 1
TACR2 tachykinin receptor 2
TAPT1 transmembrane anterior posterior transformation 1
TAS2R14 taste receptor, type 2, member 14
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TSC22D2 TSC22 domain family, member 2
ULBP2 UL16 binding protein 2
VPRBP Vpr (HIV-1) binding protein
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WAPAL wings apart-like homolog (Drosophila)
YIPF2 Yip1 domain family, member 2
ZNF280B zinc finger protein 280B

decreased expression

Symbol Name
ADGRE1 adhesion G protein-coupled receptor E1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANKH ANKH inorganic pyrophosphate transport regulator
AOAH acyloxyacyl hydrolase (neutrophil)
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
APOL6 apolipoprotein L, 6
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCAS3 breast carcinoma amplified sequence 3
BGLAP bone gamma-carboxyglutamate (gla) protein
C1QTNF3 C1q and tumor necrosis factor related protein 3
C22ORF46 chromosome 22 open reading frame 46
CD1C CD1c molecule
CDK20 cyclin-dependent kinase 20
CDR2L cerebellar degeneration-related protein 2-like
CES3 carboxylesterase 3
CGREF1 cell growth regulator with EF-hand domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHM choroideremia (Rab escort protein 1)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CISH cytokine inducible SH2-containing protein
CNTN1 contactin 1
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CPA4 carboxypeptidase A4
CTH cystathionine gamma-lyase
CTSV cathepsin V
DFNA5 deafness, autosomal dominant 5
DNMBP dynamin binding protein
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM131A family with sequence similarity 131, member A
FAM86B1 family with sequence similarity 86, member B1
FOSL1 FOS-like antigen 1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FSTL3 follistatin-like 3 (secreted glycoprotein)
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GLCE glucuronic acid epimerase
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GSTA4 glutathione S-transferase alpha 4
HIST1H1B histone cluster 1, H1b
HIST1H3G histone cluster 1, H3g
HIST1H4D histone cluster 1, H4d
HYAL3 hyaluronoglucosaminidase 3
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IPO8 importin 8
ITPKC inositol-trisphosphate 3-kinase C
LAMB3 laminin, beta 3
LAX1 lymphocyte transmembrane adaptor 1
LTBP3 latent transforming growth factor beta binding protein 3
MOCOS molybdenum cofactor sulfurase
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NABP1 nucleic acid binding protein 1
NT5M 5',3'-nucleotidase, mitochondrial
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PDZD7 PDZ domain containing 7
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPT2 palmitoyl-protein thioesterase 2
PQLC2 PQ loop repeat containing 2
PRAMEF11 PRAME family member 11
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSAT1 phosphoserine aminotransferase 1
PTCD1 pentatricopeptide repeat domain 1
PYCRL pyrroline-5-carboxylate reductase-like
RAB33A RAB33A, member RAS oncogene family
RIN2 Ras and Rab interactor 2
RNF122 ring finger protein 122
RUSC2 RUN and SH3 domain containing 2
S1PR4 sphingosine-1-phosphate receptor 4
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNX29P2 sorting nexin 29 pseudogene 2
SOX12 SRY (sex determining region Y)-box 12
SPAG1 sperm associated antigen 1
STRN striatin, calmodulin binding protein
SYCP2 synaptonemal complex protein 2
SYNJ2BP synaptojanin 2 binding protein
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TEX40 testis expressed 40
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNNT1 troponin T type 1 (skeletal, slow)
TRAF1 TNF receptor-associated factor 1
TSPYL2 TSPY-like 2
TUBB2A tubulin, beta 2A class IIa
USP19 ubiquitin specific peptidase 19
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VN1R1 vomeronasal 1 receptor 1
ZNF177 zinc finger protein 177
ZNF76 zinc finger protein 76