sirolimus-6167 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the sirolimus-6167 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN2 actinin, alpha 2
ACTN3 actinin, alpha 3 (gene/pseudogene)
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ASIC4 acid sensing (proton gated) ion channel family member 4
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2L1 BCL2-like 1
BIN1 bridging integrator 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CCSER2 coiled-coil serine-rich protein 2
CDK10 cyclin-dependent kinase 10
CHERP calcium homeostasis endoplasmic reticulum protein
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CNTD2 cyclin N-terminal domain containing 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL10A1 collagen, type X, alpha 1
CTSF cathepsin F
DCAF17 DDB1 and CUL4 associated factor 17
DLG3 discs, large homolog 3 (Drosophila)
DLGAP2 discs, large (Drosophila) homolog-associated protein 2
EFNA3 ephrin-A3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
F5 coagulation factor V (proaccelerin, labile factor)
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FCAR Fc fragment of IgA receptor
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
FSHB follicle stimulating hormone, beta polypeptide
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAL galanin/GMAP prepropeptide
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GAS1 growth arrest-specific 1
GFRA1 GDNF family receptor alpha 1
GLRA1 glycine receptor, alpha 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPM6B glycoprotein M6B
HHLA1 HERV-H LTR-associating 1
HIST1H4E histone cluster 1, H4e
HOXA4 homeobox A4
HOXB5 homeobox B5
ING1 inhibitor of growth family, member 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KIF3C kinesin family member 3C
KSR1 kinase suppressor of ras 1
MAGEH1 melanoma antigen family H1
MDFI MyoD family inhibitor
MED25 mediator complex subunit 25
MERTK MER proto-oncogene, tyrosine kinase
MR1 major histocompatibility complex, class I-related
MSR1 macrophage scavenger receptor 1
MYH14 myosin, heavy chain 14, non-muscle
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NF1 neurofibromin 1
NIPAL2 NIPA-like domain containing 2
NOD2 nucleotide-binding oligomerization domain containing 2
NPPA natriuretic peptide A
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAX4 paired box 4
PDE10A phosphodiesterase 10A
PLSCR3 phospholipid scramblase 3
PLXNB3 plexin B3
PMEL premelanosome protein
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRSS53 protease, serine, 53
PTCRA pre T-cell antigen receptor alpha
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB13 RAB13, member RAS oncogene family
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
REC8 REC8 meiotic recombination protein
RFPL1 ret finger protein-like 1
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RPS4Y1 ribosomal protein S4, Y-linked 1
RTEL1 regulator of telomere elongation helicase 1
SCN1B sodium channel, voltage gated, type I beta subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SETBP1 SET binding protein 1
SFN stratifin
SKAP1 src kinase associated phosphoprotein 1
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SPARCL1 SPARC-like 1 (hevin)
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SYT5 synaptotagmin V
TAPT1 transmembrane anterior posterior transformation 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THBS1 thrombospondin 1
TNPO2 transportin 2
TRGV5 T cell receptor gamma variable 5
UPP1 uridine phosphorylase 1
VASH1 vasohibin 1
ZDHHC8P1 zinc finger, DHHC-type containing 8 pseudogene 1
ZNF444 zinc finger protein 444

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACPP acid phosphatase, prostate
ADGRG2 adhesion G protein-coupled receptor G2
AICDA activation-induced cytidine deaminase
ATAT1 alpha tubulin acetyltransferase 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BBC3 BCL2 binding component 3
BCAS3 breast carcinoma amplified sequence 3
BGLAP bone gamma-carboxyglutamate (gla) protein
C4ORF29 chromosome 4 open reading frame 29
CAPN15 calpain 15
CCDC121 coiled-coil domain containing 121
CCDC69 coiled-coil domain containing 69
CCL21 chemokine (C-C motif) ligand 21
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDO1 cysteine dioxygenase type 1
CDR2L cerebellar degeneration-related protein 2-like
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRY2 cryptochrome circadian clock 2
CTH cystathionine gamma-lyase
CTSG cathepsin G
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DDN dendrin
DFNA5 deafness, autosomal dominant 5
EDAR ectodysplasin A receptor
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
FCHO1 FCH domain only 1
FGL1 fibrinogen-like 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GAA glucosidase, alpha; acid
GJA9 gap junction protein, alpha 9, 59kDa
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPATCH3 G patch domain containing 3
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HDAC11 histone deacetylase 11
HIST1H3G histone cluster 1, H3g
HOXA1 homeobox A1
HOXC8 homeobox C8
HPSE heparanase
HTRA1 HtrA serine peptidase 1
IQSEC2 IQ motif and Sec7 domain 2
KIAA0319L KIAA0319-like
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KRT8P12 keratin 8 pseudogene 12
LAMB3 laminin, beta 3
LRRC20 leucine rich repeat containing 20
MOB3B MOB kinase activator 3B
MVP major vault protein
N4BP2L2-IT2 N4BPL2 intronic transcript 2
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NPFFR1 neuropeptide FF receptor 1
NPIPB3 nuclear pore complex interacting protein family, member B3
PARP16 poly (ADP-ribose) polymerase family, member 16
PFN2 profilin 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POTEKP POTE ankyrin domain family, member K, pseudogene
PPCS phosphopantothenoylcysteine synthetase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKCE protein kinase C, epsilon
PRY PTPN13-like, Y-linked
PSAT1 phosphoserine aminotransferase 1
RAB3A RAB3A, member RAS oncogene family
RWDD2A RWD domain containing 2A
SIRT2 sirtuin 2
SLC16A6 solute carrier family 16, member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLMO1 slowmo homolog 1 (Drosophila)
SMR3A submaxillary gland androgen regulated protein 3A
SMYD5 SMYD family member 5
SNX29P2 sorting nexin 29 pseudogene 2
SOX21 SRY (sex determining region Y)-box 21
SPATA20 spermatogenesis associated 20
SPINT1 serine peptidase inhibitor, Kunitz type 1
STARD13 StAR-related lipid transfer (START) domain containing 13
STK16 serine/threonine kinase 16
STXBP5L syntaxin binding protein 5-like
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAS2R1 taste receptor, type 2, member 1
TMEM120B transmembrane protein 120B
TMEM57 transmembrane protein 57
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TRAF1 TNF receptor-associated factor 1
TUBB2A tubulin, beta 2A class IIa
USB1 U6 snRNA biogenesis 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR25 WD repeat domain 25
ZBTB25 zinc finger and BTB domain containing 25
ZNF177 zinc finger protein 177
ZNF345 zinc finger protein 345
ZNF696 zinc finger protein 696
ZNF747 zinc finger protein 747
ZNF76 zinc finger protein 76
ZNF862 zinc finger protein 862
ZSCAN18 zinc finger and SCAN domain containing 18