sirolimus-4466 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the sirolimus-4466 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ALOXE3 arachidonate lipoxygenase 3
AMIGO2 adhesion molecule with Ig-like domain 2
APAF1 apoptotic peptidase activating factor 1
ARL14 ADP-ribosylation factor-like 14
ARNT aryl hydrocarbon receptor nuclear translocator
BAZ2A bromodomain adjacent to zinc finger domain, 2A
CACFD1 calcium channel flower domain containing 1
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CDK20 cyclin-dependent kinase 20
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDRT1 CMT1A duplicated region transcript 1
CEMIP cell migration inducing protein, hyaluronan binding
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CIC capicua transcriptional repressor
CLCN7 chloride channel, voltage-sensitive 7
CTSZ cathepsin Z
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DENND3 DENN/MADD domain containing 3
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
ERC2-IT1 ERC2 intronic transcript 1
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
GGT1 gamma-glutamyltransferase 1
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPR182 G protein-coupled receptor 182
HBP1 HMG-box transcription factor 1
HSF2BP heat shock transcription factor 2 binding protein
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL22RA1 interleukin 22 receptor, alpha 1
IL33 interleukin 33
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB4 integrin, beta 4
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KLF13 Kruppel-like factor 13
KLHL24 kelch-like family member 24
KSR1 kinase suppressor of ras 1
LGALS8 lectin, galactoside-binding, soluble, 8
LRP1 low density lipoprotein receptor-related protein 1
LTBP4 latent transforming growth factor beta binding protein 4
MAGEA5 melanoma antigen family A5
MEGF6 multiple EGF-like-domains 6
MMP7 matrix metallopeptidase 7
MORN1 MORN repeat containing 1
MST1L macrophage stimulating 1-like
MTMR8 myotubularin related protein 8
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene)
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE4DIP phosphodiesterase 4D interacting protein
PDE5A phosphodiesterase 5A, cGMP-specific
PELI2 pellino E3 ubiquitin protein ligase family member 2
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRDM9 PR domain containing 9
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RNASE4 ribonuclease, RNase A family, 4
RND1 Rho family GTPase 1
RNF208 ring finger protein 208
RPL7 ribosomal protein L7
RUNX1 runt-related transcription factor 1
SDC3 syndecan 3
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SH3GL3 SH3-domain GRB2-like 3
SNN stannin
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
STON1 stonin 1
SZT2 seizure threshold 2 homolog (mouse)
TBL1Y transducin (beta)-like 1, Y-linked
TCP11L1 t-complex 11, testis-specific-like 1
TEF thyrotrophic embryonic factor
TENM1 teneurin transmembrane protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFR2 transferrin receptor 2
THRA thyroid hormone receptor, alpha
TMPRSS3 transmembrane protease, serine 3
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TOM1L2 target of myb1-like 2 (chicken)
TP53I11 tumor protein p53 inducible protein 11
TRIM29 tripartite motif containing 29
ULK1 unc-51 like autophagy activating kinase 1
VPS9D1 VPS9 domain containing 1
VWA5A von Willebrand factor A domain containing 5A
WDR48 WD repeat domain 48
WSB1 WD repeat and SOCS box containing 1
ZBTB20 zinc finger and BTB domain containing 20
ZNF154 zinc finger protein 154
ZNF518A zinc finger protein 518A
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
ADAM23 ADAM metallopeptidase domain 23
ARMCX2 armadillo repeat containing, X-linked 2
ATAD5 ATPase family, AAA domain containing 5
AURKC aurora kinase C
BBC3 BCL2 binding component 3
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BMPR1B bone morphogenetic protein receptor, type IB
BRIX1 BRX1, biogenesis of ribosomes
C4ORF29 chromosome 4 open reading frame 29
CAMKMT calmodulin-lysine N-methyltransferase
CCDC121 coiled-coil domain containing 121
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP295 centrosomal protein 295kDa
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYB5R2 cytochrome b5 reductase 2
DDIT4 DNA-damage-inducible transcript 4
DDN dendrin
DEPDC5 DEP domain containing 5
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
FBXL7 F-box and leucine-rich repeat protein 7
FGFBP1 fibroblast growth factor binding protein 1
FKBP5 FK506 binding protein 5
FRS2 fibroblast growth factor receptor substrate 2
FSTL3 follistatin-like 3 (secreted glycoprotein)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GFOD1 glucose-fructose oxidoreductase domain containing 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GRTP1 growth hormone regulated TBC protein 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H2BN histone cluster 1, H2bn
HIST1H3A histone cluster 1, H3a
HIST2H2AA3 histone cluster 2, H2aa3
HOXB2 homeobox B2
HSPA1L heat shock 70kDa protein 1-like
IDI2-AS1 IDI2 antisense RNA 1
IL12RB1 interleukin 12 receptor, beta 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
KIAA0020 KIAA0020
KIAA0513 KIAA0513
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLHL28 kelch-like family member 28
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KRT32 keratin 32, type I
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LIN7B lin-7 homolog B (C. elegans)
LINS lines homolog (Drosophila)
METTL16 methyltransferase like 16
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MTA2 metastasis associated 1 family, member 2
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NRTN neurturin
NXT1 nuclear transport factor 2-like export factor 1
OSMR oncostatin M receptor
PAX9 paired box 9
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PGP phosphoglycolate phosphatase
PITX2 paired-like homeodomain 2
PPAN peter pan homolog (Drosophila)
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRKG2 protein kinase, cGMP-dependent, type II
PRR14L proline rich 14-like
PTX3 pentraxin 3, long
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNDC3B RUN domain containing 3B
SAYSD1 SAYSVFN motif domain containing 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC35F6 solute carrier family 35, member F6
STAC SH3 and cysteine rich domain
TCEAL2 transcription elongation factor A (SII)-like 2
THRAP3 thyroid hormone receptor associated protein 3
TIAM2 T-cell lymphoma invasion and metastasis 2
TIPIN TIMELESS interacting protein
TMEM206 transmembrane protein 206
TRIM9 tripartite motif containing 9
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VASH1 vasohibin 1
YARS tyrosyl-tRNA synthetase
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB33 zinc finger and BTB domain containing 33
ZNF276 zinc finger protein 276
ZNF280B zinc finger protein 280B
ZNF41 zinc finger protein 41
ZNF639 zinc finger protein 639
ZNF675 zinc finger protein 675
ZNF711 zinc finger protein 711