sirolimus-4445 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the sirolimus-4445 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSS3 acyl-CoA synthetase short-chain family member 3
AMACR alpha-methylacyl-CoA racemase
ANKLE2 ankyrin repeat and LEM domain containing 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
APOE apolipoprotein E
ARL14 ADP-ribosylation factor-like 14
ATM ATM serine/threonine kinase
ATN1 atrophin 1
ATP9A ATPase, class II, type 9A
ATXN7L1 ataxin 7-like 1
BCAM basal cell adhesion molecule (Lutheran blood group)
C10ORF10 chromosome 10 open reading frame 10
CADM3 cell adhesion molecule 3
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC132 coiled-coil domain containing 132
CCNG2 cyclin G2
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CFLAR CASP8 and FADD-like apoptosis regulator
CLIC5 chloride intracellular channel 5
CPN2 carboxypeptidase N, polypeptide 2
CSF1 colony stimulating factor 1 (macrophage)
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EDN1 endothelin 1
EFCAB6 EF-hand calcium binding domain 6
ETV1 ets variant 1
FAM135A family with sequence similarity 135, member A
FAS Fas cell surface death receptor
FGF6 fibroblast growth factor 6
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS7 growth arrest-specific 7
GPR19 G protein-coupled receptor 19
GYG2 glycogenin 2
HBP1 HMG-box transcription factor 1
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGF1R insulin-like growth factor 1 receptor
IRF4 interferon regulatory factor 4
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIAA1456 KIAA1456
KIF1A kinesin family member 1A
KLF13 Kruppel-like factor 13
KLHL24 kelch-like family member 24
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KMT2A lysine (K)-specific methyltransferase 2A
LAMA4 laminin, alpha 4
LOX lysyl oxidase
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAP2K5 mitogen-activated protein kinase kinase 5
MAP2K7 mitogen-activated protein kinase kinase 7
MAP7D3 MAP7 domain containing 3
MED16 mediator complex subunit 16
MSL3 male-specific lethal 3 homolog (Drosophila)
N4BP2L1 NEDD4 binding protein 2-like 1
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NF1 neurofibromin 1
NNMT nicotinamide N-methyltransferase
NPAS3 neuronal PAS domain protein 3
NPIPB15 nuclear pore complex interacting protein family, member B15
NR1H4 nuclear receptor subfamily 1, group H, member 4
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OSBPL7 oxysterol binding protein-like 7
PADI3 peptidyl arginine deiminase, type III
PCDH12 protocadherin 12
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PRUNE2 prune homolog 2 (Drosophila)
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RAB36 RAB36, member RAS oncogene family
RNFT1 ring finger protein, transmembrane 1
SCN11A sodium channel, voltage gated, type XI alpha subunit
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SFRP4 secreted frizzled-related protein 4
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SMAD1 SMAD family member 1
SYT12 synaptotagmin XII
SZT2 seizure threshold 2 homolog (mouse)
TFEB transcription factor EB
THSD4 thrombospondin, type I, domain containing 4
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMPRSS2 transmembrane protease, serine 2
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSPAN7 tetraspanin 7
TTC30A tetratricopeptide repeat domain 30A
VEZT vezatin, adherens junctions transmembrane protein
WSB1 WD repeat and SOCS box containing 1
ZIC3 Zic family member 3
ZIM2 zinc finger, imprinted 2
ZNF516 zinc finger protein 516

decreased expression

Symbol Name
AGMAT agmatine ureohydrolase (agmatinase)
AOC2 amine oxidase, copper containing 2 (retina-specific)
ARPC5L actin related protein 2/3 complex, subunit 5-like
BATF3 basic leucine zipper transcription factor, ATF-like 3
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C3 complement component 3
CA11 carbonic anhydrase XI
CCDC85C coiled-coil domain containing 85C
CD3EAP CD3e molecule, epsilon associated protein
CD82 CD82 molecule
CENPO centromere protein O
CISH cytokine inducible SH2-containing protein
CORO1A coronin, actin binding protein, 1A
CPPED1 calcineurin-like phosphoesterase domain containing 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDN dendrin
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DENND2D DENN/MADD domain containing 2D
DHRS9 dehydrogenase/reductase (SDR family) member 9
DUSP9 dual specificity phosphatase 9
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA3 ephrin-A3
EFNB1 ephrin-B1
FBXL7 F-box and leucine-rich repeat protein 7
FBXO31 F-box protein 31
FGFBP1 fibroblast growth factor binding protein 1
FRMD1 FERM domain containing 1
GLB1L2 galactosidase, beta 1-like 2
HIST1H4C histone cluster 1, H4c
HOXC13 homeobox C13
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IFNA14 interferon, alpha 14
IL17RB interleukin 17 receptor B
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITPKA inositol-trisphosphate 3-kinase A
KLK7 kallikrein-related peptidase 7
LAMC3 laminin, gamma 3
LINC00597 long intergenic non-protein coding RNA 597
MAP6D1 MAP6 domain containing 1
MDFI MyoD family inhibitor
MFGE8 milk fat globule-EGF factor 8 protein
MMP2 matrix metallopeptidase 2
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTA2 metastasis associated 1 family, member 2
NCALD neurocalcin delta
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NID2 nidogen 2 (osteonidogen)
NOL6 nucleolar protein 6 (RNA-associated)
NTSR1 neurotensin receptor 1 (high affinity)
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae)
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PITX1 paired-like homeodomain 1
PLSCR2 phospholipid scramblase 2
PLXNB3 plexin B3
PMM2 phosphomannomutase 2
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PPAT phosphoribosyl pyrophosphate amidotransferase
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PTPRH protein tyrosine phosphatase, receptor type, H
PUS1 pseudouridylate synthase 1
PXMP4 peroxisomal membrane protein 4, 24kDa
RNF122 ring finger protein 122
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC12A9 solute carrier family 12, member 9
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLMO1 slowmo homolog 1 (Drosophila)
SOSTDC1 sclerostin domain containing 1
SPINK5 serine peptidase inhibitor, Kazal type 5
STRN striatin, calmodulin binding protein
SYT17 synaptotagmin XVII
TCEAL2 transcription elongation factor A (SII)-like 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPIN TIMELESS interacting protein
TMEM206 transmembrane protein 206
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TTLL12 tubulin tyrosine ligase-like family member 12
UNC119 unc-119 homolog (C. elegans)
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
VGF VGF nerve growth factor inducible
WDR4 WD repeat domain 4
WNT10B wingless-type MMTV integration site family, member 10B
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF124 zinc finger protein 124
ZNF222 zinc finger protein 222
ZNF639 zinc finger protein 639
ZNF747 zinc finger protein 747
ZNF787 zinc finger protein 787
ZNF816 zinc finger protein 816
ZNHIT2 zinc finger, HIT-type containing 2