sirolimus-402 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the sirolimus-402 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADH6 alcohol dehydrogenase 6 (class V)
ADRA2B adrenoceptor alpha 2B
AGFG2 ArfGAP with FG repeats 2
AQP6 aquaporin 6, kidney specific
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ASTE1 asteroid homolog 1 (Drosophila)
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
C17ORF59 chromosome 17 open reading frame 59
C1ORF61 chromosome 1 open reading frame 61
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV3 caveolin 3
CCR2 chemokine (C-C motif) receptor 2
CD79A CD79a molecule, immunoglobulin-associated alpha
CD82 CD82 molecule
CD8B CD8b molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CFAP70 cilia and flagella associated protein 70
CHD2 chromodomain helicase DNA binding protein 2
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CIITA class II, major histocompatibility complex, transactivator
CLCN6 chloride channel, voltage-sensitive 6
CLDN14 claudin 14
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
DEFA4 defensin, alpha 4, corticostatin
DENND3 DENN/MADD domain containing 3
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
EFNB3 ephrin-B3
EVPL envoplakin
FN1 fibronectin 1
FUT2 fucosyltransferase 2 (secretor status included)
GAL3ST4 galactose-3-O-sulfotransferase 4
GK2 glycerol kinase 2
GLRA2 glycine receptor, alpha 2
GPR15 G protein-coupled receptor 15
GPR173 G protein-coupled receptor 173
GPR3 G protein-coupled receptor 3
GRIP2 glutamate receptor interacting protein 2
GRPR gastrin-releasing peptide receptor
HAP1 huntingtin-associated protein 1
IFI27 interferon, alpha-inducible protein 27
IL15RA interleukin 15 receptor, alpha
IL18RAP interleukin 18 receptor accessory protein
IL1B interleukin 1, beta
IL5RA interleukin 5 receptor, alpha
IL7R interleukin 7 receptor
INSL4 insulin-like 4 (placenta)
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
KLHL28 kelch-like family member 28
KRTAP1-1 keratin associated protein 1-1
LHX2 LIM homeobox 2
LIMS2 LIM and senescent cell antigen-like domains 2
LMO3 LIM domain only 3 (rhombotin-like 2)
LMTK2 lemur tyrosine kinase 2
LOC441601 septin 7 pseudogene
LRP4 low density lipoprotein receptor-related protein 4
LRP6 low density lipoprotein receptor-related protein 6
LTK leukocyte receptor tyrosine kinase
LUZP4 leucine zipper protein 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MC5R melanocortin 5 receptor
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MYL2 myosin, light chain 2, regulatory, cardiac, slow
NDRG2 NDRG family member 2
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PCYT1B phosphate cytidylyltransferase 1, choline, beta
PHOX2A paired-like homeobox 2a
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARG retinoic acid receptor, gamma
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RBMXL2 RNA binding motif protein, X-linked-like 2
SLAMF8 SLAM family member 8
SLC22A17 solute carrier family 22, member 17
SLC45A2 solute carrier family 45, member 2
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMAD3 SMAD family member 3
SYT2 synaptotagmin II
TCP11 t-complex 11, testis-specific
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TP53TG5 TP53 target 5
TRAC T cell receptor alpha constant
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TTC22 tetratricopeptide repeat domain 22
TYMP thymidine phosphorylase
USF2 upstream transcription factor 2, c-fos interacting
USP29 ubiquitin specific peptidase 29
USP46 ubiquitin specific peptidase 46
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
VARS valyl-tRNA synthetase

decreased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ACAD10 acyl-CoA dehydrogenase family, member 10
AES amino-terminal enhancer of split
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARMC7 armadillo repeat containing 7
C16ORF59 chromosome 16 open reading frame 59
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative)
CBX7 chromobox homolog 7
CCDC130 coiled-coil domain containing 130
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEP72 centrosomal protein 72kDa
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLDN17 claudin 17
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CLSTN2 calsyntenin 2
CROT carnitine O-octanoyltransferase
CRY1 cryptochrome circadian clock 1
CRYBB2P1 crystallin, beta B2 pseudogene 1
CUEDC1 CUE domain containing 1
CYB5R2 cytochrome b5 reductase 2
DGKD diacylglycerol kinase, delta 130kDa
ECE2 endothelin converting enzyme 2
EFNA3 ephrin-A3
EXOC5 exocyst complex component 5
EYA3 EYA transcriptional coactivator and phosphatase 3
FANCF Fanconi anemia, complementation group F
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FXN frataxin
GADD45A growth arrest and DNA-damage-inducible, alpha
GALR3 galanin receptor 3
GMEB1 glucocorticoid modulatory element binding protein 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMHA1 histocompatibility (minor) HA-1
IL4R interleukin 4 receptor
ITPKB inositol-trisphosphate 3-kinase B
JOSD1 Josephin domain containing 1
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KDM8 lysine (K)-specific demethylase 8
KIF20B kinesin family member 20B
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KLHL2 kelch-like family member 2
KREMEN2 kringle containing transmembrane protein 2
LINC00574 long intergenic non-protein coding RNA 574
LTBP3 latent transforming growth factor beta binding protein 3
MAP3K6 mitogen-activated protein kinase kinase kinase 6
METTL8 methyltransferase like 8
MGA MGA, MAX dimerization protein
MON1B MON1 secretory trafficking family member B
MORC3 MORC family CW-type zinc finger 3
MRPL12 mitochondrial ribosomal protein L12
MXD3 MAX dimerization protein 3
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NKAIN1 Na+/K+ transporting ATPase interacting 1
NPIPB3 nuclear pore complex interacting protein family, member B3
OR7A17 olfactory receptor, family 7, subfamily A, member 17
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PCDHB3 protocadherin beta 3
PCTP phosphatidylcholine transfer protein
PECR peroxisomal trans-2-enoyl-CoA reductase
PFAS phosphoribosylformylglycinamidine synthase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLCD1 phospholipase C, delta 1
RAD54L RAD54-like (S. cerevisiae)
RAI14 retinoic acid induced 14
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RGS17 regulator of G-protein signaling 17
RHOH ras homolog family member H
RNF185 ring finger protein 185
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLIT2 slit homolog 2 (Drosophila)
SMCO4 single-pass membrane protein with coiled-coil domains 4
SPEG SPEG complex locus
T T, brachyury homolog (mouse)
TCEA2 transcription elongation factor A (SII), 2
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
THOC6 THO complex 6
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TJP2 tight junction protein 2
TOE1 target of EGR1, member 1 (nuclear)
TTC1 tetratricopeptide repeat domain 1
TTC4 tetratricopeptide repeat domain 4
TTR transthyretin
TUBGCP3 tubulin, gamma complex associated protein 3
WDR18 WD repeat domain 18
WDR46 WD repeat domain 46
WDR91 WD repeat domain 91
WT1-AS WT1 antisense RNA
WWC2 WW and C2 domain containing 2
ZFP36 ZFP36 ring finger protein