sirolimus-362 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the sirolimus-362 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACVR1B activin A receptor, type IB
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AQP6 aquaporin 6, kidney specific
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
AURKA aurora kinase A
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
C16ORF58 chromosome 16 open reading frame 58
CADM3 cell adhesion molecule 3
CARTPT CART prepropeptide
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD5 CD5 molecule
CDHR2 cadherin-related family member 2
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DHRS9 dehydrogenase/reductase (SDR family) member 9
DIO2 deiodinase, iodothyronine, type II
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
ERMP1 endoplasmic reticulum metallopeptidase 1
FGFBP1 fibroblast growth factor binding protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
GBAP1 glucosidase, beta, acid pseudogene 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GHRHR growth hormone releasing hormone receptor
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GLP1R glucagon-like peptide 1 receptor
GLRA2 glycine receptor, alpha 2
GPR107 G protein-coupled receptor 107
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HEATR6 HEAT repeat containing 6
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HTRA1 HtrA serine peptidase 1
IL19 interleukin 19
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KIFAP3 kinesin-associated protein 3
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLHL25 kelch-like family member 25
KLHL28 kelch-like family member 28
KRT85 keratin 85, type II
LINC00339 long intergenic non-protein coding RNA 339
LPP LIM domain containing preferred translocation partner in lipoma
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAX MYC associated factor X
MST1 macrophage stimulating 1
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCAPH2 non-SMC condensin II complex, subunit H2
NEU3 sialidase 3 (membrane sialidase)
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NKIRAS2 NFKB inhibitor interacting Ras-like 2
NOTCH4 notch 4
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OSBPL10 oxysterol binding protein-like 10
PDLIM4 PDZ and LIM domain 4
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKD2L1 polycystic kidney disease 2-like 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POU2F2 POU class 2 homeobox 2
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PQLC3 PQ loop repeat containing 3
PRDM14 PR domain containing 14
PTGDS prostaglandin D2 synthase 21kDa (brain)
RANBP17 RAN binding protein 17
RHOBTB2 Rho-related BTB domain containing 2
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RUNDC3A RUN domain containing 3A
SCN5A sodium channel, voltage gated, type V alpha subunit
SEC23IP SEC23 interacting protein
SH3GL3 SH3-domain GRB2-like 3
SIM2 single-minded family bHLH transcription factor 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
STX1A syntaxin 1A (brain)
STXBP5L syntaxin binding protein 5-like
TCP10L t-complex 10-like
TFE3 transcription factor binding to IGHM enhancer 3
TG thyroglobulin
TGM3 transglutaminase 3
TMEM127 transmembrane protein 127
TMF1 TATA element modulatory factor 1
TMPRSS6 transmembrane protease, serine 6
TP53TG5 TP53 target 5
TP63 tumor protein p63
TP73-AS1 TP73 antisense RNA 1
TSPAN7 tetraspanin 7
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
YLPM1 YLP motif containing 1
ZC3H13 zinc finger CCCH-type containing 13
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF473 zinc finger protein 473

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ADM2 adrenomedullin 2
ADRA2B adrenoceptor alpha 2B
AMN amnion associated transmembrane protein
APOL6 apolipoprotein L, 6
APOLD1 apolipoprotein L domain containing 1
AQP8 aquaporin 8
ASB13 ankyrin repeat and SOCS box containing 13
ATF7IP2 activating transcription factor 7 interacting protein 2
ATXN2L ataxin 2-like
AXIN1 axin 1
BCL7B B-cell CLL/lymphoma 7B
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C5ORF28 chromosome 5 open reading frame 28
CCNO cyclin O
CD151 CD151 molecule (Raph blood group)
CEP41 centrosomal protein 41kDa
CFAP74 cilia and flagella associated protein 74
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CMA1 chymase 1, mast cell
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
EYA3 EYA transcriptional coactivator and phosphatase 3
F3 coagulation factor III (thromboplastin, tissue factor)
FAM189B family with sequence similarity 189, member B
FAM76A family with sequence similarity 76, member A
FGGY FGGY carbohydrate kinase domain containing
FOLR3 folate receptor 3 (gamma)
FTCD formimidoyltransferase cyclodeaminase
FZD4 frizzled class receptor 4
GLI3 GLI family zinc finger 3
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUCA1B guanylate cyclase activator 1B (retina)
HAPLN2 hyaluronan and proteoglycan link protein 2
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
IFITM3 interferon induced transmembrane protein 3
ITGB7 integrin, beta 7
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
LRRC16A leucine rich repeat containing 16A
LRRC48 leucine rich repeat containing 48
MCOLN1 mucolipin 1
MFSD12 major facilitator superfamily domain containing 12
MOCS2 molybdenum cofactor synthesis 2
MOCS3 molybdenum cofactor synthesis 3
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSMO1 methylsterol monooxygenase 1
MTCP1 mature T-cell proliferation 1
MVD mevalonate (diphospho) decarboxylase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NPC1L1 NPC1-like 1
NUP93 nucleoporin 93kDa
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAGR1 PAXIP1 associated glutamate-rich protein 1
PALM paralemmin
PAX1 paired box 1
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDZD7 PDZ domain containing 7
PICK1 protein interacting with PRKCA 1
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
PLEK2 pleckstrin 2
PMP22 peripheral myelin protein 22
PODNL1 podocan-like 1
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPP4C protein phosphatase 4, catalytic subunit
PRKY protein kinase, Y-linked, pseudogene
PROL1 proline rich, lacrimal 1
PRSS8 protease, serine, 8
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
PTDSS2 phosphatidylserine synthase 2
PTPRT protein tyrosine phosphatase, receptor type, T
QPRT quinolinate phosphoribosyltransferase
QTRT1 queuine tRNA-ribosyltransferase 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RNF144A ring finger protein 144A
RNF186 ring finger protein 186
RPAP2 RNA polymerase II associated protein 2
RPH3A rabphilin 3A
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SETMAR SET domain and mariner transposase fusion gene
SIL1 SIL1 nucleotide exchange factor
SMA4 glucuronidase, beta pseudogene
TET3 tet methylcytosine dioxygenase 3
TLR8 toll-like receptor 8
TMED1 transmembrane emp24 protein transport domain containing 1
TPM3 tropomyosin 3
TPSG1 tryptase gamma 1
TRABD TraB domain containing
TTN titin
TTPA tocopherol (alpha) transfer protein
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
ZNF557 zinc finger protein 557
ZNHIT2 zinc finger, HIT-type containing 2