sirolimus-2702 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the sirolimus-2702 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
AASS aminoadipate-semialdehyde synthase
ACSM1 acyl-CoA synthetase medium-chain family member 1
ADAM20 ADAM metallopeptidase domain 20
ADAM3A ADAM metallopeptidase domain 3A (pseudogene)
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
APOE apolipoprotein E
ASPH aspartate beta-hydroxylase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BGN biglycan
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CD300C CD300c molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
COL5A1 collagen, type V, alpha 1
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CPT1A carnitine palmitoyltransferase 1A (liver)
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CREM cAMP responsive element modulator
CSHL1 chorionic somatomammotropin hormone-like 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DDR1 discoidin domain receptor tyrosine kinase 1
DGCR8 DGCR8 microprocessor complex subunit
EGOT eosinophil granule ontogeny transcript (non-protein coding)
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHA5 EPH receptor A5
EPN2 epsin 2
EXPH5 exophilin 5
FDXR ferredoxin reductase
FMO3 flavin containing monooxygenase 3
FNTB farnesyltransferase, CAAX box, beta
FOXO4 forkhead box O4
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GLE1 GLE1 RNA export mediator
GLRA2 glycine receptor, alpha 2
GUCA2B guanylate cyclase activator 2B (uroguanylin)
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HIPK3 homeodomain interacting protein kinase 3
HTR7P1 5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
HUS1 HUS1 checkpoint homolog (S. pombe)
IL17RC interleukin 17 receptor C
IL1R1 interleukin 1 receptor, type I
JPH3 junctophilin 3
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6
KMT2A lysine (K)-specific methyltransferase 2A
LAMC3 laminin, gamma 3
LBX1 ladybird homeobox 1
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
MAP9 microtubule-associated protein 9
MYO7A myosin VIIA
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NID1 nidogen 1
NME8 NME/NM23 family member 8
NPC1 Niemann-Pick disease, type C1
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OLFM4 olfactomedin 4
ONECUT2 one cut homeobox 2
PAX1 paired box 1
PCDHGA8 protocadherin gamma subfamily A, 8
PDE11A phosphodiesterase 11A
PDE4DIP phosphodiesterase 4D interacting protein
PDLIM5 PDZ and LIM domain 5
PHF3 PHD finger protein 3
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PHTF2 putative homeodomain transcription factor 2
PLA2G3 phospholipase A2, group III
PLCE1 phospholipase C, epsilon 1
PLXDC1 plexin domain containing 1
PP14571 uncharacterized LOC100130449
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRO2964 uncharacterized protein PRO2964
PVT1 Pvt1 oncogene (non-protein coding)
RAB38 RAB38, member RAS oncogene family
RBP4 retinol binding protein 4, plasma
RPL3L ribosomal protein L3-like
RPLP2 ribosomal protein, large, P2
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SORBS1 sorbin and SH3 domain containing 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STK3 serine/threonine kinase 3
STON1 stonin 1
SULF1 sulfatase 1
SYT13 synaptotagmin XIII
TESK1 testis-specific kinase 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIM2 tripartite motif containing 2
USP6NL USP6 N-terminal like
WNT8B wingless-type MMTV integration site family, member 8B
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZFHX3 zinc finger homeobox 3
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF385D zinc finger protein 385D

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ALOX12 arachidonate 12-lipoxygenase
ANKRD55 ankyrin repeat domain 55
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARMC7 armadillo repeat containing 7
ASPN asporin
BCAS3 breast carcinoma amplified sequence 3
BDKRB1 bradykinin receptor B1
C19ORF73 chromosome 19 open reading frame 73
CCDC92 coiled-coil domain containing 92
CD160 CD160 molecule
CDK20 cyclin-dependent kinase 20
CEMP1 cementum protein 1
CEP97 centrosomal protein 97kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLGN calmegin
CLIP2 CAP-GLY domain containing linker protein 2
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CORO2B coronin, actin binding protein, 2B
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CST1 cystatin SN
CTH cystathionine gamma-lyase
DTX2 deltex 2, E3 ubiquitin ligase
EXD3 exonuclease 3'-5' domain containing 3
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXL6 F-box and leucine-rich repeat protein 6
FSD1 fibronectin type III and SPRY domain containing 1
GABARAPL3 GABA(A) receptors associated protein like 3, pseudogene
GAREM GRB2 associated, regulator of MAPK1
GATA6 GATA binding protein 6
GID4 GID complex subunit 4
GPR22 G protein-coupled receptor 22
GPR3 G protein-coupled receptor 3
GTF2IRD1 GTF2I repeat domain containing 1
HIST1H1E histone cluster 1, H1e
HRH2 histamine receptor H2
IBSP integrin-binding sialoprotein
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IL12RB2 interleukin 12 receptor, beta 2
IQSEC2 IQ motif and Sec7 domain 2
IRF7 interferon regulatory factor 7
IRS1 insulin receptor substrate 1
JAM3 junctional adhesion molecule 3
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KANSL3 KAT8 regulatory NSL complex subunit 3
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KIAA1024 KIAA1024
KLK5 kallikrein-related peptidase 5
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LIG4 ligase IV, DNA, ATP-dependent
LIMD2 LIM domain containing 2
MAK male germ cell-associated kinase
MDM4 MDM4, p53 regulator
MEFV Mediterranean fever
MLPH melanophilin
MREG melanoregulin
MXD3 MAX dimerization protein 3
MYBPC1 myosin binding protein C, slow type
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
NBEA neurobeachin
NEUROD1 neuronal differentiation 1
OXCT2 3-oxoacid CoA transferase 2
PADI2 peptidyl arginine deiminase, type II
PDGFRL platelet-derived growth factor receptor-like
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PSAT1 phosphoserine aminotransferase 1
PYGB phosphorylase, glycogen; brain
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBM47 RNA binding motif protein 47
REM1 RAS (RAD and GEM)-like GTP-binding 1
RIN2 Ras and Rab interactor 2
RNF122 ring finger protein 122
RWDD2A RWD domain containing 2A
SH3PXD2A SH3 and PX domains 2A
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SLITRK5 SLIT and NTRK-like family, member 5
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
STC2 stanniocalcin 2
SV2B synaptic vesicle glycoprotein 2B
SYCP2 synaptonemal complex protein 2
TEX15 testis expressed 15
THBS3 thrombospondin 3
TMEM212 transmembrane protein 212
TMEM246 transmembrane protein 246
TMEM53 transmembrane protein 53
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TPM3 tropomyosin 3
TRAF2 TNF receptor-associated factor 2
TSC22D4 TSC22 domain family, member 4
UNC13A unc-13 homolog A (C. elegans)
VN1R1 vomeronasal 1 receptor 1
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZNF276 zinc finger protein 276
ZNF528 zinc finger protein 528
ZNF76 zinc finger protein 76
ZNF768 zinc finger protein 768