simvastatin-4244 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the simvastatin-4244 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
AHNAK AHNAK nucleoprotein
AMPD1 adenosine monophosphate deaminase 1
ANGPT1 angiopoietin 1
ANGPTL4 angiopoietin-like 4
APAF1 apoptotic peptidase activating factor 1
AQP3 aquaporin 3 (Gill blood group)
ARC activity-regulated cytoskeleton-associated protein
ARHGAP28 Rho GTPase activating protein 28
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BCL2L11 BCL2-like 11 (apoptosis facilitator)
C14ORF79 chromosome 14 open reading frame 79
C1S complement component 1, s subcomponent
CCL23 chemokine (C-C motif) ligand 23
CD226 CD226 molecule
CDC14A cell division cycle 14A
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CNGA1 cyclic nucleotide gated channel alpha 1
CYSLTR2 cysteinyl leukotriene receptor 2
DLK2 delta-like 2 homolog (Drosophila)
DMBT1 deleted in malignant brain tumors 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EXOSC2 exosome component 2
EZR ezrin
FLOT1 flotillin 1
FRMD4B FERM domain containing 4B
GAL3ST4 galactose-3-O-sulfotransferase 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR161 G protein-coupled receptor 161
GRIA3 glutamate receptor, ionotropic, AMPA 3
GYPB glycophorin B (MNS blood group)
HAP1 huntingtin-associated protein 1
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP7 insulin-like growth factor binding protein 7
IL1RN interleukin 1 receptor antagonist
INE1 inactivation escape 1 (non-protein coding)
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KRT6A keratin 6A, type II
LDB3 LIM domain binding 3
LEPR leptin receptor
LIG3 ligase III, DNA, ATP-dependent
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LMTK2 lemur tyrosine kinase 2
MAN2A2 mannosidase, alpha, class 2A, member 2
MAPK10 mitogen-activated protein kinase 10
MARK1 MAP/microtubule affinity-regulating kinase 1
METTL7A methyltransferase like 7A
MT1F metallothionein 1F
MT1X metallothionein 1X
MUC5B mucin 5B, oligomeric mucus/gel-forming
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NCOA3 nuclear receptor coactivator 3
NDNF neuron-derived neurotrophic factor
NME5 NME/NM23 family member 5
NOV nephroblastoma overexpressed
OBSL1 obscurin-like 1
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE4DIP phosphodiesterase 4D interacting protein
PDGFA platelet-derived growth factor alpha polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PER1 period circadian clock 1
PKP4 plakophilin 4
PML promyelocytic leukemia
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRR5 proline rich 5 (renal)
PTGES prostaglandin E synthase
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
RIMS2 regulating synaptic membrane exocytosis 2
RPL10L ribosomal protein L10-like
RUNX1 runt-related transcription factor 1
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SPINK5 serine peptidase inhibitor, Kazal type 5
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK17A serine/threonine kinase 17a
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
THTPA thiamine triphosphatase
TLR1 toll-like receptor 1
TNIK TRAF2 and NCK interacting kinase
TRIM29 tripartite motif containing 29
TSC22D2 TSC22 domain family, member 2
VAMP5 vesicle-associated membrane protein 5
VNN2 vanin 2
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF141 zinc finger protein 141

decreased expression

Symbol Name
ALOX12 arachidonate 12-lipoxygenase
ANXA2P1 annexin A2 pseudogene 1
ARRB2 arrestin, beta 2
AXIN1 axin 1
BIRC3 baculoviral IAP repeat containing 3
C14ORF105 chromosome 14 open reading frame 105
C22ORF46 chromosome 22 open reading frame 46
C5ORF42 chromosome 5 open reading frame 42
C7ORF69 chromosome 7 open reading frame 69
CBX8 chromobox homolog 8
CCL2 chemokine (C-C motif) ligand 2
CCNO cyclin O
CCNT1 cyclin T1
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD68 CD68 molecule
CD82 CD82 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDHR2 cadherin-related family member 2
CLCA1 chloride channel accessory 1
CLDN1 claudin 1
CNGB3 cyclic nucleotide gated channel beta 3
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNOT3 CCR4-NOT transcription complex, subunit 3
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CRABP2 cellular retinoic acid binding protein 2
CXCR2 chemokine (C-X-C motif) receptor 2
CXORF21 chromosome X open reading frame 21
CYR61 cysteine-rich, angiogenic inducer, 61
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFCAB2 EF-hand calcium binding domain 2
EFHD2 EF-hand domain family, member D2
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EYA3 EYA transcriptional coactivator and phosphatase 3
FRMPD1 FERM and PDZ domain containing 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GBX2 gastrulation brain homeobox 2
GLS2 glutaminase 2 (liver, mitochondrial)
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HAMP hepcidin antimicrobial peptide
HIST1H2BN histone cluster 1, H2bn
IL36RN interleukin 36 receptor antagonist
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KDM5C lysine (K)-specific demethylase 5C
KDM8 lysine (K)-specific demethylase 8
KRT34 keratin 34, type I
LINC00597 long intergenic non-protein coding RNA 597
LMO7 LIM domain 7
LPAR4 lysophosphatidic acid receptor 4
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LY6D lymphocyte antigen 6 complex, locus D
MFGE8 milk fat globule-EGF factor 8 protein
MTSS1L metastasis suppressor 1-like
MX1 MX dynamin-like GTPase 1
MYL9 myosin, light chain 9, regulatory
MYO1F myosin IF
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NAT6 N-acetyltransferase 6 (GCN5-related)
NPFFR1 neuropeptide FF receptor 1
ODF2 outer dense fiber of sperm tails 2
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PALM paralemmin
PCDHGB5 protocadherin gamma subfamily B, 5
PDE12 phosphodiesterase 12
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLBD1 phospholipase B domain containing 1
POLL polymerase (DNA directed), lambda
PRB3 proline-rich protein BstNI subfamily 3
PRM2 protamine 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RAPSN receptor-associated protein of the synapse
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF2 ring finger protein 2
ROGDI rogdi homolog (Drosophila)
RUNX1-IT1 RUNX1 intronic transcript 1
SAYSD1 SAYSVFN motif domain containing 1
SCAMP4 secretory carrier membrane protein 4
SLC16A6 solute carrier family 16, member 6
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SORBS3 sorbin and SH3 domain containing 3
SOX12 SRY (sex determining region Y)-box 12
SP1 Sp1 transcription factor
SPTBN2 spectrin, beta, non-erythrocytic 2
SSBP3 single stranded DNA binding protein 3
STK16 serine/threonine kinase 16
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBC1D22B TBC1 domain family, member 22B
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TSC22D4 TSC22 domain family, member 4
UGT8 UDP glycosyltransferase 8
USP20 ubiquitin specific peptidase 20
WNT1 wingless-type MMTV integration site family, member 1
ZNF254 zinc finger protein 254
ZYX zyxin