simvastatin-3340 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the simvastatin-3340 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD17B abhydrolase domain containing 17B
ADCY3 adenylate cyclase 3
AKAP4 A kinase (PRKA) anchor protein 4
ANTXR1 anthrax toxin receptor 1
AQP3 aquaporin 3 (Gill blood group)
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATF3 activating transcription factor 3
BCAP29 B-cell receptor-associated protein 29
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLCA1 chloride channel accessory 1
CLIC5 chloride intracellular channel 5
CNPY4 canopy FGF signaling regulator 4
CNTN5 contactin 5
COL1A1 collagen, type I, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL5A2 collagen, type V, alpha 2
COLEC10 collectin sub-family member 10 (C-type lectin)
CXCR4 chemokine (C-X-C motif) receptor 4
DEAF1 DEAF1 transcription factor
DES desmin
DMRT1 doublesex and mab-3 related transcription factor 1
DNALI1 dynein, axonemal, light intermediate chain 1
DOCK9 dedicator of cytokinesis 9
DOK4 docking protein 4
EFNB3 ephrin-B3
EGR1 early growth response 1
EPHB2 EPH receptor B2
FGFR3 fibroblast growth factor receptor 3
FOSL2 FOS-like antigen 2
GABARAPL3 GABA(A) receptors associated protein like 3, pseudogene
GNAS GNAS complex locus
GPR182 G protein-coupled receptor 182
GPR22 G protein-coupled receptor 22
GRIK5 glutamate receptor, ionotropic, kainate 5
HIST1H3B histone cluster 1, H3b
HOXA10 homeobox A10
HOXB2 homeobox B2
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
ICA1 islet cell autoantigen 1, 69kDa
IDS iduronate 2-sulfatase
IL12RB1 interleukin 12 receptor, beta 1
INHA inhibin, alpha
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB4 integrin, beta 4
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KIAA0391 KIAA0391
KIAA1324 KIAA1324
KLF6 Kruppel-like factor 6
KLHL22 kelch-like family member 22
KRT15 keratin 15, type I
LMO3 LIM domain only 3 (rhombotin-like 2)
MEF2D myocyte enhancer factor 2D
MIR622 microRNA 622
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NDRG2 NDRG family member 2
NF1 neurofibromin 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NME5 NME/NM23 family member 5
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OXCT2 3-oxoacid CoA transferase 2
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
PCDH1 protocadherin 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PER1 period circadian clock 1
PIGR polymeric immunoglobulin receptor
PLLP plasmolipin
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POMT2 protein-O-mannosyltransferase 2
PRDX2 peroxiredoxin 2
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RAB3B RAB3B, member RAS oncogene family
RAB6B RAB6B, member RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RBMS2 RNA binding motif, single stranded interacting protein 2
REM1 RAS (RAD and GEM)-like GTP-binding 1
RPL35A ribosomal protein L35a
SBNO1 strawberry notch homolog 1 (Drosophila)
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SPDEF SAM pointed domain containing ETS transcription factor
SPRED2 sprouty-related, EVH1 domain containing 2
SRSF7 serine/arginine-rich splicing factor 7
SSTR5 somatostatin receptor 5
SUGP1 SURP and G patch domain containing 1
TBCD tubulin folding cofactor D
TFEB transcription factor EB
TKTL1 transketolase-like 1
TRIM38 tripartite motif containing 38
WSCD1 WSC domain containing 1
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
AARSD1 alanyl-tRNA synthetase domain containing 1
ABLIM3 actin binding LIM protein family, member 3
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AFF4 AF4/FMR2 family, member 4
ANXA2P3 annexin A2 pseudogene 3
ARL15 ADP-ribosylation factor-like 15
ARMC6 armadillo repeat containing 6
ARMCX2 armadillo repeat containing, X-linked 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BATF basic leucine zipper transcription factor, ATF-like
C5AR2 complement component 5a receptor 2
C9ORF9 chromosome 9 open reading frame 9
CCNK cyclin K
CCNL2 cyclin L2
CCP110 centriolar coiled coil protein 110kDa
CEP97 centrosomal protein 97kDa
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DUSP2 dual specificity phosphatase 2
EDAR ectodysplasin A receptor
ELOVL4 ELOVL fatty acid elongase 4
F2R coagulation factor II (thrombin) receptor
FAIM Fas apoptotic inhibitory molecule
FAM186A family with sequence similarity 186, member A
FER fer (fps/fes related) tyrosine kinase
GADD45G growth arrest and DNA-damage-inducible, gamma
GBAS glioblastoma amplified sequence
GMEB1 glucocorticoid modulatory element binding protein 1
GMPR guanosine monophosphate reductase
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HIST1H2AI histone cluster 1, H2ai
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMGB3P1 high mobility group box 3 pseudogene 1
IL22 interleukin 22
INPP5J inositol polyphosphate-5-phosphatase J
IPO8 importin 8
IQCG IQ motif containing G
JUNB jun B proto-oncogene
KDM5C lysine (K)-specific demethylase 5C
KDM7A lysine (K)-specific demethylase 7A
KLHL36 kelch-like family member 36
LHX1 LIM homeobox 1
LIN7B lin-7 homolog B (C. elegans)
LMNB1 lamin B1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP9 microtubule-associated protein 9
MTERF1 mitochondrial transcription termination factor 1
MXD3 MAX dimerization protein 3
NLRX1 NLR family member X1
NOD1 nucleotide-binding oligomerization domain containing 1
NPY1R neuropeptide Y receptor Y1
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NXPH4 neurexophilin 4
PCBP4 poly(rC) binding protein 4
PCDHA6 protocadherin alpha 6
PHEX phosphate regulating endopeptidase homolog, X-linked
PITX2 paired-like homeodomain 2
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHO2 pleckstrin homology domain containing, family O member 2
PODXL2 podocalyxin-like 2
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
RAB3A RAB3A, member RAS oncogene family
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPAP1 RNA polymerase II associated protein 1
RPL10L ribosomal protein L10-like
SDC3 syndecan 3
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH2B3 SH2B adaptor protein 3
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMS spermine synthase
SND1-IT1 SND1 intronic transcript 1
SPTBN2 spectrin, beta, non-erythrocytic 2
STARD5 StAR-related lipid transfer (START) domain containing 5
THRB thyroid hormone receptor, beta
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM120B transmembrane protein 120B
TMEM121 transmembrane protein 121
TRIM36 tripartite motif containing 36
TTF2 transcription termination factor, RNA polymerase II
TUBA3D tubulin, alpha 3d
UNC93B1 unc-93 homolog B1 (C. elegans)
USB1 U6 snRNA biogenesis 1
VLDLR very low density lipoprotein receptor
WDR33 WD repeat domain 33
WDR91 WD repeat domain 91
XDH xanthine dehydrogenase
XYLT2 xylosyltransferase II
ZBTB6 zinc finger and BTB domain containing 6
ZNF205 zinc finger protein 205
ZNF273 zinc finger protein 273
ZNF358 zinc finger protein 358
ZNF573 zinc finger protein 573
ZNF675 zinc finger protein 675
ZSCAN26 zinc finger and SCAN domain containing 26
ZSWIM1 zinc finger, SWIM-type containing 1