silicosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles. (Human Disease Ontology, DOID_10325)
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Genes

125 genes co-occuring with the disease silicosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SEC14L3 SEC14-like 3 (S. cerevisiae) 1.36684
TGFB1 transforming growth factor, beta 1 1.12994
TNF tumor necrosis factor 1.09293
FASLG Fas ligand (TNF superfamily, member 6) 0.99908
ZBTB32 zinc finger and BTB domain containing 32 0.95745
SOD2 superoxide dismutase 2, mitochondrial 0.931242
MARCO macrophage receptor with collagenous structure 0.881062
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.879424
IL1B interleukin 1, beta 0.847078
ACRV1 acrosomal vesicle protein 1 0.842163
MRPL13 mitochondrial ribosomal protein L13 0.835198
ACE angiotensin I converting enzyme 0.824948
PRDX1 peroxiredoxin 1 0.802385
CD4 CD4 molecule 0.787213
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.778204
EGR1 early growth response 1 0.742329
NLRP3 NLR family, pyrin domain containing 3 0.724907
FN1 fibronectin 1 0.698313
ADAP2 ArfGAP with dual PH domains 2 0.697911
CAT catalase 0.682693
SIGLEC7 sialic acid binding Ig-like lectin 7 0.619834
IL1RN interleukin 1 receptor antagonist 0.606543
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.597181
CP ceruloplasmin (ferroxidase) 0.593285
FCMR Fc fragment of IgM receptor 0.57655
YME1L1 YME1-like 1 ATPase 0.574605
LYZ lysozyme 0.573828
DSG3 desmoglein 3 0.566831
SFTPD surfactant protein D 0.554791
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 0.540829
IL1A interleukin 1, alpha 0.533088
MPO myeloperoxidase 0.528449
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 0.526132
IGKV1D-42 immunoglobulin kappa variable 1D-42 (non-functional) 0.523045
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 0.522659
FBXO44 F-box protein 44 0.513033
OVGP1 oviductal glycoprotein 1, 120kDa 0.510344
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.488549
SMAD7 SMAD family member 7 0.487788
IL17F interleukin 17F 0.482084
LRRC38 leucine rich repeat containing 38 0.477151
GPX5 glutathione peroxidase 5 0.465416
GPX4 glutathione peroxidase 4 0.462394
TRIP10 thyroid hormone receptor interactor 10 0.460883
PGM1 phosphoglucomutase 1 0.452585
CD79A CD79a molecule, immunoglobulin-associated alpha 0.452208
PPT1 palmitoyl-protein thioesterase 1 0.450324
GPX1 glutathione peroxidase 1 0.446935
HAGH hydroxyacylglutathione hydrolase 0.446182
KRT75 keratin 75, type II 0.445429
PAM peptidylglycine alpha-amidating monooxygenase 0.443171
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.440538
GLO1 glyoxalase I 0.42589
GLB1 galactosidase, beta 1 0.422515
SUMO1 small ubiquitin-like modifier 1 0.411283
CARD17 caspase recruitment domain family, member 17 0.390397
RNASEH2A ribonuclease H2, subunit A 0.379626
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.378514
C3 complement component 3 0.375179
PRTN3 proteinase 3 0.374438
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.373698
DSG1 desmoglein 1 0.371107
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.359657
MINK1 misshapen-like kinase 1 0.359289
CCL3 chemokine (C-C motif) ligand 3 0.358551
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.353027
CCL2 chemokine (C-C motif) ligand 2 0.352659
LRG1 leucine-rich alpha-2-glycoprotein 1 0.35082
TIMP1 TIMP metallopeptidase inhibitor 1 0.350452
POMC proopiomelanocortin 0.345308
NLRC4 NLR family, CARD domain containing 4 0.341639
CTSE cathepsin E 0.340173
ELN elastin 0.333218
CRP C-reactive protein, pentraxin-related 0.331025
PATE1 prostate and testis expressed 1 0.322273
RETNLB resistin like beta 0.318999
HP haptoglobin 0.315003
MMP13 matrix metallopeptidase 13 0.312102
HMOX1 heme oxygenase 1 0.311739
HPR haptoglobin-related protein 0.309204
SRRM1 serine/arginine repetitive matrix 1 0.306672
GC group-specific component (vitamin D binding protein) 0.298371
SCARB2 scavenger receptor class B, member 2 0.284013
CD69 CD69 molecule 0.279367
GUSB glucuronidase, beta 0.278654
FOXD3 forkhead box D3 0.273664
CHIA chitinase, acidic 0.272953
IL6 interleukin 6 0.272597
CD36 CD36 molecule (thrombospondin receptor) 0.269043
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.260891
ALB albumin 0.254888
JUN jun proto-oncogene 0.254536
CCL24 chemokine (C-C motif) ligand 24 0.247501
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.241895
CTSD cathepsin D 0.23945
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.238054
SRPX2 sushi-repeat containing protein, X-linked 2 0.238054
AIM2 absent in melanoma 2 0.233183
MMP12 matrix metallopeptidase 12 0.231795
ACOT13 acyl-CoA thioesterase 13 0.231448
SCARB1 scavenger receptor class B, member 1 0.231102
CTSH cathepsin H 0.229716
CLEC3B C-type lectin domain family 3, member B 0.216332
IL9 interleukin 9 0.211597
FOXP3 forkhead box P3 0.207578
WDR11 WD repeat domain 11 0.205916
IL12B interleukin 12B 0.202946
FGF2 fibroblast growth factor 2 (basic) 0.199681
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.199356
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.192657
MMP2 matrix metallopeptidase 2 0.191408
CXCL8 chemokine (C-X-C motif) ligand 8 0.190476
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 0.184128
TOP1 topoisomerase (DNA) I 0.18151
SPP1 secreted phosphoprotein 1 0.175947
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 0.174881
EDA ectodysplasin A 0.174354
NELFCD negative elongation factor complex member C/D 0.173832
NT5E 5'-nucleotidase, ecto (CD73) 0.171036
CD68 CD68 molecule 0.167224
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.166095
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 0.165655
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.161331
CTSS cathepsin S 0.158951
SIX1 SIX homeobox 1 0.158434