signal recognition particle, endoplasmic reticulum targeting Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. (Gene Ontology, GO_0005786)
Similar Terms
Downloads & Tools

Genes

7 proteins localized to the signal recognition particle, endoplasmic reticulum targeting cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SRP54 signal recognition particle 54kDa 0.663342
SRP68 signal recognition particle 68kDa 0.663342
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.663342
SRP19 signal recognition particle 19kDa 0.663342
SRP9P1 signal recognition particle 9 pseudogene 1 0.663342
SRP9 signal recognition particle 9kDa 0.663342
SRP72 signal recognition particle 72kDa 0.663342