sickle Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

113 genes co-occuring with the biological term sickle in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALK anaplastic lymphoma receptor tyrosine kinase
ALPL alkaline phosphatase, liver/bone/kidney
ANXA2 annexin A2
ANXA5 annexin A5
APOE apolipoprotein E
AQP8 aquaporin 8
ARG1 arginase 1
ARG2 arginase 2
AVP arginine vasopressin
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BDNF brain-derived neurotrophic factor
BMP6 bone morphogenetic protein 6
CCL5 chemokine (C-C motif) ligand 5
CD1A CD1a molecule
CD1B CD1b molecule
CD1C CD1c molecule
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CD81 CD81 molecule
CRP C-reactive protein, pentraxin-related
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
EDN1 endothelin 1
EGR1 early growth response 1
F10 coagulation factor X
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FGF23 fibroblast growth factor 23
G6PC glucose-6-phosphatase, catalytic subunit
G6PD glucose-6-phosphate dehydrogenase
GCH1 GTP cyclohydrolase 1
GOLGB1 golgin B1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HAMP hepcidin antimicrobial peptide
HBA1 hemoglobin, alpha 1
HBA2 hemoglobin, alpha 2
HBB hemoglobin, beta
HBFQTL2 hereditary persistence of fetal hemoglobin, heterocellular
HBS1L HBS1-like translational GTPase
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HP haptoglobin
HPFH2 hereditary persistence of fetal hemoglobin, heterocellular, Indian type
ICAM1 intercellular adhesion molecule 1
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KL klotho
KLF2 Kruppel-like factor 2
LAMA5 laminin, alpha 5
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MBL2 mannose-binding lectin (protein C) 2, soluble
MIR15A microRNA 15a
MIR16-1 microRNA 16-1
MPO myeloperoxidase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYB v-myb avian myeloblastosis viral oncogene homolog
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX1 NADPH oxidase 1
NPPB natriuretic peptide B
PDE4A phosphodiesterase 4A, cAMP-specific
PDE9A phosphodiesterase 9A
PDGFA platelet-derived growth factor alpha polypeptide
PGF placental growth factor
PRKCA protein kinase C, alpha
PRMT5 protein arginine methyltransferase 5
PROZ protein Z, vitamin K-dependent plasma glycoprotein
RAP1A RAP1A, member of RAS oncogene family
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHCE Rh blood group, CcEe antigens
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SOD2 superoxide dismutase 2, mitochondrial
TFRC transferrin receptor
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
UGT1A UDP glucuronosyltransferase 1 family, polypeptide A complex locus
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
VCAM1 vascular cell adhesion molecule 1
VCL vinculin
VEGFA vascular endothelial growth factor A