sickle cell Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description An erythrocyte shaped like a sickle or crescent owing to the presence of hemoglobin S, seen in sickle cell anemia and other sickle cell diseases. (BRENDA Tissue and Enzyme Source Ontology, BTO_0002656)
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Genes

261 proteins co-occuring with the tissue sickle cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
HBB hemoglobin, beta 2.78611
HBG2 hemoglobin, gamma G 2.66822
HBD hemoglobin, delta 2.33796
SCN2A sodium channel, voltage gated, type II alpha subunit 2.26581
HBS1L HBS1-like translational GTPase 2.09311
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 1.92111
HBA2 hemoglobin, alpha 2 1.90343
HBA1 hemoglobin, alpha 1 1.8998
BCAM basal cell adhesion molecule (Lutheran blood group) 1.81023
G6PD glucose-6-phosphate dehydrogenase 1.80107
HBE1 hemoglobin, epsilon 1 1.71887
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 1.68005
FTL ferritin, light polypeptide 1.62507
FTH1 ferritin, heavy polypeptide 1 1.60862
KLF1 Kruppel-like factor 1 (erythroid) 1.49585
VCAM1 vascular cell adhesion molecule 1 1.45053
RHCE Rh blood group, CcEe antigens 1.432
F5 coagulation factor V (proaccelerin, labile factor) 1.3878
CYGB cytoglobin 1.37545
RHD Rh blood group, D antigen 1.33681
F2 coagulation factor II (thrombin) 1.27247
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.26844
HP haptoglobin 1.25771
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.25458
HPR haptoglobin-related protein 1.24476
PROS1 protein S (alpha) 1.23405
SPTB spectrin, beta, erythrocytic 1.23405
MYB v-myb avian myeloblastosis viral oncogene homolog 1.19889
TF transferrin 1.19534
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.17624
FABP9 fatty acid binding protein 9, testis 1.17136
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.15362
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 1.14476
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 1.14432
VWF von Willebrand factor 1.09031
TFRC transferrin receptor 1.05237
CRP C-reactive protein, pentraxin-related 1.04796
RPAP3 RNA polymerase II associated protein 3 1.04181
HBG1 hemoglobin, gamma A 1.03829
CD36 CD36 molecule (thrombospondin receptor) 1.03302
F3 coagulation factor III (thromboplastin, tissue factor) 1.01549
SCARB2 scavenger receptor class B, member 2 1.01506
ALB albumin 1.01112
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.959017
SSFA2 sperm specific antigen 2 0.959017
JMJD6 jumonji domain containing 6 0.947809
MIPEP mitochondrial intermediate peptidase 0.945226
SCARB1 scavenger receptor class B, member 1 0.938777
LAMA5 laminin, alpha 5 0.926764
HMOX1 heme oxygenase 1 0.926336
NOS3 nitric oxide synthase 3 (endothelial cell) 0.922055
OR51B5 olfactory receptor, family 51, subfamily B, member 5 0.920344
SCAND1 SCAN domain containing 1 0.900296
ALPPL2 alkaline phosphatase, placental-like 2 0.883321
ALPL alkaline phosphatase, liver/bone/kidney 0.882474
ALPP alkaline phosphatase, placental 0.881627
OR10A4 olfactory receptor, family 10, subfamily A, member 4 0.874862
HAMP hepcidin antimicrobial peptide 0.873172
ICAM1 intercellular adhesion molecule 1 0.864312
EPB41 erythrocyte membrane protein band 4.1 0.861363
SELE selectin E 0.849165
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.844545
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.844126
CD47 CD47 molecule 0.823175
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 0.81774
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.816068
PF4 platelet factor 4 0.814815
HLA-C major histocompatibility complex, class I, C 0.810221
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.809803
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 0.809386
PKLR pyruvate kinase, liver and RBC 0.807716
CD34 CD34 molecule 0.801876
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 0.786883
PLA2G10 phospholipase A2, group X 0.781894
TCHP trichoplein, keratin filament binding 0.780648
PGF placental growth factor 0.778155
APOA1 apolipoprotein A-I 0.778155
ZBED9 zinc finger, BED-type containing 9 0.773174
SHB Src homology 2 domain containing adaptor protein B 0.766125
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 0.766125
TTC27 tetratricopeptide repeat domain 27 0.764054
PHC3 polyhomeotic homolog 3 (Drosophila) 0.762811
ADORA2B adenosine A2b receptor 0.757432
PHF20L1 PHD finger protein 20-like 1 0.75247
ANXA5 annexin A5 0.747102
ANK1 ankyrin 1, erythrocytic 0.740503
PDE5A phosphodiesterase 5A, cGMP-specific 0.728975
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 0.723631
HBZ hemoglobin, zeta 0.717061
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.710909
MB myoglobin 0.704355
DHCR24 24-dehydrocholesterol reductase 0.698625
BTNL2 butyrophilin-like 2 0.696581
ACE angiotensin I converting enzyme 0.688
PGBD1 piggyBac transposable element derived 1 0.67984
PKM pyruvate kinase, muscle 0.674135
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.673321
HPX hemopexin 0.671692
QKI QKI, KH domain containing, RNA binding 0.668436
THBS1 thrombospondin 1 0.668029
COMMD7 COMM domain containing 7 0.661116
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.6461
RHAG Rh-associated glycoprotein 0.644074
SELL selectin L 0.640833
OR10K1 olfactory receptor, family 10, subfamily K, member 1 0.632335
EDN1 endothelin 1 0.621831
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 0.608527
FN1 fibronectin 1 0.604099
CAT catalase 0.603697
KEL Kell blood group, metallo-endopeptidase 0.595255
DMTN dematin actin binding protein 0.595255
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 0.586828
CD79A CD79a molecule, immunoglobulin-associated alpha 0.581218
NARF nuclear prelamin A recognition factor 0.573217
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 0.567227
AHSP alpha hemoglobin stabilizing protein 0.563637
SCAND2P SCAN domain containing 2 pseudogene 0.56284
TREX1 three prime repair exonuclease 1 0.559254
TNF tumor necrosis factor 0.553286
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 0.548914
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.548517
CXCL8 chemokine (C-X-C motif) ligand 8 0.546533
FYB FYN binding protein 0.541773
HOOK3 hook microtubule-tethering protein 3 0.539396
SOD2 superoxide dismutase 2, mitochondrial 0.536229
GPX1 glutathione peroxidase 1 0.534647
PLA2G1B phospholipase A2, group IB (pancreas) 0.531089
BATF basic leucine zipper transcription factor, ATF-like 0.52635
NFE2 nuclear factor, erythroid 2 0.51571
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 0.512957
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.50942
CFI complement factor I 0.493354
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.489447
KL klotho 0.487496
EPGN epithelial mitogen 0.487106
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.485545
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.476589
APOL1 apolipoprotein L, 1 0.474646
THBD thrombomodulin 0.471927
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 0.470763
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.468436
IL3 interleukin 3 0.46766
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.466111
EPO erythropoietin 0.465335
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 0.4634
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.45567
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.45374
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.453355
SLC4A3 solute carrier family 4 (anion exchanger), member 3 0.452969
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.452198
CFP complement factor properdin 0.445653
APOB apolipoprotein B 0.442962
PLAT plasminogen activator, tissue 0.44181
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila) 0.436822
IL6 interleukin 6 0.436822
MGAM maltase-glucoamylase 0.435672
TBCD tubulin folding cofactor D 0.435672
TGFBR3 transforming growth factor, beta receptor III 0.424199
GDF15 growth differentiation factor 15 0.423436
F8 coagulation factor VIII, procoagulant component 0.421529
IL1B interleukin 1, beta 0.417337
GPX5 glutathione peroxidase 5 0.417337
LPA lipoprotein, Lp(a) 0.417337
GPX4 glutathione peroxidase 4 0.413532
MARVELD3 MARVEL domain containing 3 0.410491
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 0.405935
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.399114
CSF3 colony stimulating factor 3 (granulocyte) 0.393442
HFE hemochromatosis 0.391176
RIN3 Ras and Rab interactor 3 0.390799
SHE Src homology 2 domain containing E 0.390421
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.390044
IL17RE interleukin 17 receptor E 0.388535
HLA-A major histocompatibility complex, class I, A 0.383637
PRMT5 protein arginine methyltransferase 5 0.382508
TTR transthyretin 0.371619
NFE2L2 nuclear factor, erythroid 2-like 2 0.368998
COL2A1 collagen, type II, alpha 1 0.367876
MFGE8 milk fat globule-EGF factor 8 protein 0.364139
CD40LG CD40 ligand 0.362273
IL17RD interleukin 17 receptor D 0.362273
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.361901
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 0.360409
LIAS lipoic acid synthetase 0.352227
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 0.350743
GUCY2C guanylate cyclase 2C 0.34926
KAT6A K(lysine) acetyltransferase 6A 0.34926
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.34926
CD163 CD163 molecule 0.347778
NPR1 natriuretic peptide receptor 1 0.347038
GPANK1 G patch domain and ankyrin repeats 1 0.344079
SARNP SAP domain containing ribonucleoprotein 0.341495
FOXG1 forkhead box G1 0.338177
GBA2 glucosidase, beta (bile acid) 2 0.33156
FH fumarate hydratase 0.329361
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.329361
SALL2 spalt-like transcription factor 2 0.328628
SPTA1 spectrin, alpha, erythrocytic 1 0.327164
VCL vinculin 0.325335
DPPA2 developmental pluripotency associated 2 0.323144
IFT122 intraflagellar transport 122 0.320591
MEFV Mediterranean fever 0.31877
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.312595
ERAS ES cell expressed Ras 0.310059
ALK anaplastic lymphoma receptor tyrosine kinase 0.309697
PDS5B PDS5 cohesin associated factor B 0.306083
GATA2 GATA binding protein 2 0.303919
GFER growth factor, augmenter of liver regeneration 0.301758
MPO myeloperoxidase 0.301398
GYPE glycophorin E (MNS blood group) 0.298883
ADA adenosine deaminase 0.296372
COX5A cytochrome c oxidase subunit Va 0.296372
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 0.295297
EXOSC8 exosome component 8 0.295297
SEPT1 septin 1 0.293151
LCAT lecithin-cholesterol acyltransferase 0.285671
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.284962
TAAR8 trace amine associated receptor 8 0.284607
F13A1 coagulation factor XIII, A1 polypeptide 0.283545
EDNRA endothelin receptor type A 0.278955
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.272649
GSR glutathione reductase 0.268828
NANP N-acetylneuraminic acid phosphatase 0.268137
TRIM21 tripartite motif containing 21 0.267446
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 0.266069
MIB2 mindbomb E3 ubiquitin protein ligase 2 0.265038
FLT1 fms-related tyrosine kinase 1 0.263327
SYK spleen tyrosine kinase 0.262645
ALAS2 5'-aminolevulinate synthase 2 0.261284
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.259591
SOX6 SRY (sex determining region Y)-box 6 0.258917
PHIP pleckstrin homology domain interacting protein 0.2559
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.255234
ADORA2A adenosine A2a receptor 0.253578
EMP1 epithelial membrane protein 1 0.249653
TFE3 transcription factor binding to IGHM enhancer 3 0.245175
BPGM 2,3-bisphosphoglycerate mutase 0.24486
PDE7B phosphodiesterase 7B 0.244232
HDAC9 histone deacetylase 9 0.243918
DNAH8 dynein, axonemal, heavy chain 8 0.237216
KDM1A lysine (K)-specific demethylase 1A 0.236627
RTN3 reticulon 3 0.235748
ESAM endothelial cell adhesion molecule 0.234016
COMT catechol-O-methyltransferase 0.233731
PLEKHN1 pleckstrin homology domain containing, family N member 1 0.232599
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.231206
EPOR erythropoietin receptor 0.230931
SDPR serum deprivation response 0.23011
ARHGAP4 Rho GTPase activating protein 4 0.23011
PTH parathyroid hormone 0.227707
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.225144
FGD1 FYVE, RhoGEF and PH domain containing 1 0.22246
NCOA2 nuclear receptor coactivator 2 0.220831
BMP6 bone morphogenetic protein 6 0.219928
C3 complement component 3 0.218613
FAM3B family with sequence similarity 3, member B 0.217554
MIR26B microRNA 26b 0.217346
PDE4D phosphodiesterase 4D, cAMP-specific 0.21673
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 0.216528
SSPN sarcospan 0.21573
SMTNL1 smoothelin-like 1 0.213833