sickle cell anemia Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description OMIM mapping confirmed by DO. [LS]. (Human Disease Ontology, DOID_10923)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:10923
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Genes

72 genes associated with the disease sickle cell anemia in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 2.45432
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 2.35337
OR51B5 olfactory receptor, family 51, subfamily B, member 5 2.29228
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 2.1454
HBB hemoglobin, beta 2.14038
UBQLNL ubiquilin-like 1.97129
HBG1 hemoglobin, gamma A 1.94201
OR51F1 olfactory receptor, family 51, subfamily F, member 1 (gene/pseudogene) 1.7812
OR52I2 olfactory receptor, family 52, subfamily I, member 2 1.68619
CSNK2A1 casein kinase 2, alpha 1 polypeptide 1.51327
OR51E2 olfactory receptor, family 51, subfamily E, member 2 1.49392
OR51I1 olfactory receptor, family 51, subfamily I, member 1 1.45434
RRM1 ribonucleotide reductase M1 1.41484
STIM1 stromal interaction molecule 1 1.39735
OTUD3 OTU deubiquitinase 3 1.38169
OR51B6 olfactory receptor, family 51, subfamily B, member 6 1.37833
PCIF1 PDX1 C-terminal inhibiting factor 1 1.33447
NAP1L4 nucleosome assembly protein 1-like 4 1.32614
CSMD1 CUB and Sushi multiple domains 1 1.29628
RFX3 regulatory factor X, 3 (influences HLA class II expression) 1.26546
HBZ hemoglobin, zeta 1.25348
SYT9 synaptotagmin IX 1.22816
MCC mutated in colorectal cancers 1.19386
CDH9 cadherin 9, type 2 (T1-cadherin) 1.18698
ZBED9 zinc finger, BED-type containing 9 1.138
PHEX phosphate regulating endopeptidase homolog, X-linked 1.10764
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 1.09927
PHACTR1 phosphatase and actin regulator 1 1.08832
HYKK hydroxylysine kinase 1.08598
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 1.07992
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.07599
CDH26 cadherin 26 1.05943
CLEC12B C-type lectin domain family 12, member B 1.04846
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 1.04365
HK2 hexokinase 2 1.02661
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 1.02476
THRB thyroid hormone receptor, beta 1.00407
NLGN4X neuroligin 4, X-linked 0.990056
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.986376
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.962747
BMPR1A bone morphogenetic protein receptor, type IA 0.961144
MAP2K5 mitogen-activated protein kinase kinase 5 0.959689
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.958374
IL17RD interleukin 17 receptor D 0.958374
DSCAM Down syndrome cell adhesion molecule 0.949336
TMEM233 transmembrane protein 233 0.940135
SYCE3 synaptonemal complex central element protein 3 0.928472
PRMT8 protein arginine methyltransferase 8 0.927636
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.916706
CNTN4 contactin 4 0.908515
SPRED3 sprouty-related, EVH1 domain containing 3 0.905653
NRP1 neuropilin 1 0.903565
SNX29 sorting nexin 29 0.895671
DRD2 dopamine receptor D2 0.884624
CDH13 cadherin 13 0.881544
PPAP2B phosphatidic acid phosphatase type 2B 0.879151
MED27 mediator complex subunit 27 0.869616
PAX8 paired box 8 0.862937
ASUN asunder spermatogenesis regulator 0.859451
USP43 ubiquitin specific peptidase 43 0.857874
WWOX WW domain containing oxidoreductase 0.851323
RAD51B RAD51 paralog B 0.838567
SVIL supervillin 0.837296
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 0.810892
RNF220 ring finger protein 220 0.809818
JAKMIP1 janus kinase and microtubule interacting protein 1 0.808055
KLHL33 kelch-like family member 33 0.803948
UROC1 urocanate hydratase 1 0.778649
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.77125
C14ORF132 chromosome 14 open reading frame 132 0.766405
LOC643542 uncharacterized LOC643542 0.755268
ACAN aggrecan 0.722673