sickle cell anemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description OMIM mapping confirmed by DO. [LS]. (Human Disease Ontology, DOID_10923)
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Genes

185 genes co-occuring with the disease sickle cell anemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HBG2 hemoglobin, gamma G 2.53746
HBB hemoglobin, beta 1.98529
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 1.76366
HBS1L HBS1-like translational GTPase 1.74597
HBD hemoglobin, delta 1.55026
SCN2A sodium channel, voltage gated, type II alpha subunit 1.39564
HBA1 hemoglobin, alpha 1 1.38647
HBA2 hemoglobin, alpha 2 1.38516
OR51B5 olfactory receptor, family 51, subfamily B, member 5 1.28435
SPTB spectrin, beta, erythrocytic 1.25124
MIPEP mitochondrial intermediate peptidase 1.20007
MYB v-myb avian myeloblastosis viral oncogene homolog 1.18238
OR51B6 olfactory receptor, family 51, subfamily B, member 6 1.13628
OR51B2 olfactory receptor, family 51, subfamily B, member 2 (gene/pseudogene) 1.13628
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 1.12614
FABP9 fatty acid binding protein 9, testis 1.09041
HBE1 hemoglobin, epsilon 1 1.07026
FTH1 ferritin, heavy polypeptide 1 1.04882
FTL ferritin, light polypeptide 1.04882
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.965405
KLF1 Kruppel-like factor 1 (erythroid) 0.948269
BTNL2 butyrophilin-like 2 0.922149
PKLR pyruvate kinase, liver and RBC 0.911845
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 0.900335
HBG1 hemoglobin, gamma A 0.899924
VCAM1 vascular cell adhesion molecule 1 0.899514
G6PD glucose-6-phosphate dehydrogenase 0.882701
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 0.879014
PBLD phenazine biosynthesis-like protein domain containing 0.869596
EPB41 erythrocyte membrane protein band 4.1 0.859771
FYB FYN binding protein 0.849945
HAO2 hydroxyacid oxidase 2 (long chain) 0.829459
PRKG1 protein kinase, cGMP-dependent, type I 0.825358
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 0.821257
PPAN peter pan homolog (Drosophila) 0.813052
CYGB cytoglobin 0.80977
GOLGB1 golgin B1 0.783936
SCARB2 scavenger receptor class B, member 2 0.77575
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 0.77207
CD36 CD36 molecule (thrombospondin receptor) 0.758601
F3 coagulation factor III (thromboplastin, tissue factor) 0.757378
TFRC transferrin receptor 0.74761
BPGM 2,3-bisphosphoglycerate mutase 0.742329
SCARB1 scavenger receptor class B, member 1 0.714811
NR2C2 nuclear receptor subfamily 2, group C, member 2 0.71078
SELE selectin E 0.695504
F5 coagulation factor V (proaccelerin, labile factor) 0.688291
HLA-C major histocompatibility complex, class I, C 0.683493
PKM pyruvate kinase, muscle 0.666755
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.652089
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.642221
SOX6 SRY (sex determining region Y)-box 6 0.639857
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.631598
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 0.624927
TF transferrin 0.622575
F2 coagulation factor II (thrombin) 0.604981
SSR1 signal sequence receptor, alpha 0.592895
ANXA7 annexin A7 0.58433
BCAM basal cell adhesion molecule (Lutheran blood group) 0.564889
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.555568
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.554791
ICAM1 intercellular adhesion molecule 1 0.552463
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.550134
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.548971
MAP7 microtubule-associated protein 7 0.546256
TGFBR3 transforming growth factor, beta receptor III 0.542379
HP haptoglobin 0.529222
HPR haptoglobin-related protein 0.523045
GPM6B glycoprotein M6B 0.521502
MGAM maltase-glucoamylase 0.498849
PROS1 protein S (alpha) 0.498849
VWF von Willebrand factor 0.498085
CD34 CD34 molecule 0.493885
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.493122
HELT helt bHLH transcription factor 0.490072
KL klotho 0.487027
RHCE Rh blood group, CcEe antigens 0.482844
TSPY10 testis specific protein, Y-linked 10 0.478668
TSPY3 testis specific protein, Y-linked 3 0.478668
ZFPM1 zinc finger protein, FOG family member 1 0.472982
IL3 interleukin 3 0.470332
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.468441
ALB albumin 0.459373
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.459373
ALPP alkaline phosphatase, placental 0.428516
SALL2 spalt-like transcription factor 2 0.42739
SPTA1 spectrin, alpha, erythrocytic 1 0.424389
PDE7B phosphodiesterase 7B 0.420266
EPO erythropoietin 0.419892
AES amino-terminal enhancer of split 0.408666
HAMP hepcidin antimicrobial peptide 0.406425
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 0.404184
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 0.401199
GYPA glycophorin A (MNS blood group) 0.398589
ALPPL2 alkaline phosphatase, placental-like 2 0.393001
ALPL alkaline phosphatase, liver/bone/kidney 0.391885
GBA2 glucosidase, beta (bile acid) 2 0.391141
PDE9A phosphodiesterase 9A 0.385193
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.381481
CAT catalase 0.370368
BATF basic leucine zipper transcription factor, ATF-like 0.368149
JAK3 Janus kinase 3 0.362239
F8 coagulation factor VIII, procoagulant component 0.360395
RHD Rh blood group, D antigen 0.35892
DLX4 distal-less homeobox 4 0.35892
LYZ lysozyme 0.352659
ANXA5 annexin A5 0.35082
F10 coagulation factor X 0.350452
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.350452
DNAH8 dynein, axonemal, heavy chain 8 0.345675
ST5 suppression of tumorigenicity 5 0.345308
FOXG1 forkhead box G1 0.343106
GSTM1 glutathione S-transferase mu 1 0.328834
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 0.32774
CHD4 chromodomain helicase DNA binding protein 4 0.317182
GSTA1 glutathione S-transferase alpha 1 0.317182
IRF6 interferon regulatory factor 6 0.316092
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.309928
GCLC glutamate-cysteine ligase, catalytic subunit 0.306672
FN1 fibronectin 1 0.305587
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.303781
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.303781
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.303781
BMP6 bone morphogenetic protein 6 0.299092
TNF tumor necrosis factor 0.298011
ANK1 ankyrin 1, erythrocytic 0.292975
GSTTP1 glutathione S-transferase theta pseudogene 1 0.291898
GSTT1 glutathione S-transferase theta 1 0.291539
BMPR1B bone morphogenetic protein receptor, type IB 0.290821
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 0.290821
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 0.283655
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 0.283297
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 0.282225
KCNK6 potassium channel, two pore domain subfamily K, member 6 0.279367
MIR26B microRNA 26b 0.272953
TRPC5 transient receptor potential cation channel, subfamily C, member 5 0.270819
HAVCR1 hepatitis A virus cellular receptor 1 0.267977
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.265494
TPI1 triosephosphate isomerase 1 0.264431
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.260184
KRT84 keratin 84, type II 0.257005
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 0.254888
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 0.254183
UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5 0.25207
ADRB2 adrenoceptor beta 2, surface 0.251366
SNORA29 small nucleolar RNA, H/ACA box 29 0.237009
SULF2 sulfatase 2 0.23492
GPX1 glutathione peroxidase 1 0.233878
CST3 cystatin C 0.226607
TRPC6 transient receptor potential cation channel, subfamily C, member 6 0.222822
HPSE2 heparanase 2 (inactive) 0.221793
ADCY9 adenylate cyclase 9 0.220081
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.215992
GDF15 growth differentiation factor 15 0.213621
SELL selectin L 0.208245
DCPS decapping enzyme, scavenger 0.207912
CD1B CD1b molecule 0.20658
ENO3 enolase 3 (beta, muscle) 0.202618
ARG2 arginase 2 0.201962
CCL5 chemokine (C-C motif) ligand 5 0.201308
ZBED9 zinc finger, BED-type containing 9 0.200331
GLB1 galactosidase, beta 1 0.196779
SFTPA1 surfactant protein A1 0.192031
LGALS7 lectin, galactoside-binding, soluble, 7 0.191719
JUNB jun B proto-oncogene 0.187415
CFAP74 cilia and flagella associated protein 74 0.18651
SMAD6 SMAD family member 6 0.184128
CFP complement factor properdin 0.182666
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 0.179239
POLL polymerase (DNA directed), lambda 0.175947
PGAM2 phosphoglycerate mutase 2 (muscle) 0.174881
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.173832
GPX5 glutathione peroxidase 5 0.168854
ACVR2A activin A receptor, type IIA 0.168617
EDN1 endothelin 1 0.168617
GPX4 glutathione peroxidase 4 0.166768
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 0.166544
RFX1 regulatory factor X, 1 (influences HLA class II expression) 0.163317
KEL Kell blood group, metallo-endopeptidase 0.163111
KLF2 Kruppel-like factor 2 0.162109
GSTA3 glutathione S-transferase alpha 3 0.159124
SMAD5 SMAD family member 5 0.158778
GSTA2 glutathione S-transferase alpha 2 0.158434
CRP C-reactive protein, pentraxin-related 0.158266
GSTA4 glutathione S-transferase alpha 4 0.157929