sexual disorder Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A disease of mental health that involves the impairment in normal sexual functioning. (Human Disease Ontology, DOID_0060043)
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Genes

228 genes co-occuring with the disease sexual disorder in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PDE5A phosphodiesterase 5A, cGMP-specific 2.42427
SHBG sex hormone-binding globulin 1.85182
KLK3 kallikrein-related peptidase 3 1.78399
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.58537
PRL prolactin 1.53613
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.39652
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.30183
ADRA1D adrenoceptor alpha 1D 1.11603
BCR breakpoint cluster region 1.09965
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 1.08327
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.07236
AR androgen receptor 1.05135
MC4R melanocortin 4 receptor 1.04672
ACE angiotensin I converting enzyme 0.964148
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.931656
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.925452
INS insulin 0.89582
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.889668
ATG4C autophagy related 4C, cysteine peptidase 0.861818
MAOA monoamine oxidase A 0.846259
PAPLN papilin, proteoglycan-like sulfated glycoprotein 0.844211
EGOT eosinophil granule ontogeny transcript (non-protein coding) 0.840934
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.825358
HFE hemochromatosis 0.817976
NOS3 nitric oxide synthase 3 (endothelial cell) 0.800744
BMP2K BMP2 inducible kinase 0.793771
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.787213
APOLD1 apolipoprotein L domain containing 1 0.756564
POMC proopiomelanocortin 0.746391
OXTR oxytocin receptor 0.742329
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.72127
CES1P1 carboxylesterase 1 pseudogene 1 0.69751
LHB luteinizing hormone beta polypeptide 0.695504
BATF2 basic leucine zipper transcription factor, ATF-like 2 0.680697
PNP purine nucleoside phosphorylase 0.662387
TRH thyrotropin-releasing hormone 0.661594
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 0.643404
TTR transthyretin 0.63907
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.636708
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.633169
MED29 mediator complex subunit 29 0.625711
EGF epidermal growth factor 0.616312
PDE11A phosphodiesterase 11A 0.60264
AAAS achalasia, adrenocortical insufficiency, alacrimia 0.60225
IPP intracisternal A particle-promoted polypeptide 0.60186
MIB2 mindbomb E3 ubiquitin protein ligase 2 0.59952
CAPS2 calcyphosine 2 0.583552
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.580439
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 0.559839
VIP vasoactive intestinal peptide 0.559062
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 0.557897
LY96 lymphocyte antigen 96 0.557509
PPAN peter pan homolog (Drosophila) 0.55518
NPR1 natriuretic peptide receptor 1 0.552075
GUCY2C guanylate cyclase 2C 0.550911
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.545481
PDE4A phosphodiesterase 4A, cAMP-specific 0.540442
ESR1 estrogen receptor 1 0.519575
ZNF135 zinc finger protein 135 0.517265
MC3R melanocortin 3 receptor 0.507273
IGF1 insulin-like growth factor 1 (somatomedin C) 0.494266
TF transferrin 0.492359
PDLIM2 PDZ and LIM domain 2 (mystique) 0.471089
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.469197
PDE1B phosphodiesterase 1B, calmodulin-dependent 0.46655
NPS neuropeptide S 0.458241
PTH parathyroid hormone 0.455224
CLCF1 cardiotrophin-like cytokine factor 1 0.454093
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.4443
ACPT acid phosphatase, testicular 0.442795
C6ORF25 chromosome 6 open reading frame 25 0.423265
CFD complement factor D (adipsin) 0.421765
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.421765
TBX3 T-box 3 0.421016
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 0.415773
GRHL1 grainyhead-like 1 (Drosophila) 0.415398
UROS uroporphyrinogen III synthase 0.407545
AASS aminoadipate-semialdehyde synthase 0.407172
NPY neuropeptide Y 0.393374
DRD2 dopamine receptor D2 0.380739
IFNLR1 interferon, lambda receptor 1 0.371107
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.366301
MC5R melanocortin 5 receptor 0.364454
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 0.363716
LEP leptin 0.358551
PTDSS1 phosphatidylserine synthase 1 0.353027
NOVA2 neuro-oncological ventral antigen 2 0.351187
CLMP CXADR-like membrane protein 0.350452
HDAC10 histone deacetylase 10 0.347511
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.345675
HRH1 histamine receptor H1 0.345675
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.344941
AKTIP AKT interacting protein 0.34384
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.342372
FTH1 ferritin, heavy polypeptide 1 0.341272
FTL ferritin, light polypeptide 0.337608
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.336876
PARP14 poly (ADP-ribose) polymerase family, member 14 0.336876
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) 0.335046
NLE1 notchless homolog 1 (Drosophila) 0.335046
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.334315
ALB albumin 0.333583
SIRPA signal-regulatory protein alpha 0.332121
CD4 CD4 molecule 0.32993
STPG1 sperm-tail PG-rich repeat containing 1 0.324458
KLF11 Kruppel-like factor 11 0.323002
CRH corticotropin releasing hormone 0.322637
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.320817
MPST mercaptopyruvate sulfurtransferase 0.318999
ARR3 arrestin 3, retinal (X-arrestin) 0.304503
STAR steroidogenic acute regulatory protein 0.304503
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.299812
MVD mevalonate (diphospho) decarboxylase 0.299092
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.298011
KRT75 keratin 75, type II 0.292257
USH1G Usher syndrome 1G (autosomal recessive) 0.289744
BDNF brain-derived neurotrophic factor 0.281153
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.278709
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.272597
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.270464
GRP gastrin-releasing peptide 0.265494
NOS1 nitric oxide synthase 1 (neuronal) 0.257711
GDF6 growth differentiation factor 6 0.255594
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 0.255594
TAC1 tachykinin, precursor 1 0.254536
HFE2 hemochromatosis type 2 (juvenile) 0.251718
LACTB lactamase, beta 0.251718
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.250663
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.243295
GHRH growth hormone releasing hormone 0.242945
SEPT3 septin 3 0.242595
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 0.237706
LIF leukemia inhibitory factor 0.23353
CD1A CD1a molecule 0.232489
TFR2 transferrin receptor 2 0.226607
FLNA filamin A, alpha 0.223853
KIAA0101 KIAA0101 0.218715
ACPP acid phosphatase, prostate 0.218034
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 0.217012
GRIK4 glutamate receptor, ionotropic, kainate 4 0.214297
ICT1 immature colon carcinoma transcript 1 0.208914
REN renin 0.207245
HSD17B1P1 hydroxysteroid (17-beta) dehydrogenase 1 pseudogene 1 0.20658
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 0.205254
METTL13 methyltransferase like 13 0.200982
EDN1 endothelin 1 0.199033
GHRL ghrelin/obestatin prepropeptide 0.197742
OPN3 opsin 3 0.189244
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.185313
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.185313
DKKL1 dickkopf-like 1 0.18472
ADRA1A adrenoceptor alpha 1A 0.182666
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.179802
ADD2 adducin 2 (beta) 0.178126
HAS1 hyaluronan synthase 1 0.178126
SMTNL1 smoothelin-like 1 0.176757
SHF Src homology 2 domain containing F 0.176215
B3GAT2 beta-1,3-glucuronyltransferase 2 0.174881
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.173057
HEXB hexosaminidase B (beta polypeptide) 0.172799
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.172799
SOX3 SRY (sex determining region Y)-box 3 0.169812
SMTN smoothelin 0.16933
SST somatostatin 0.168148
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.165217
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.165217
HSPG2 heparan sulfate proteoglycan 2 0.165001
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 0.163317
KCNK2 potassium channel, two pore domain subfamily K, member 2 0.163111
EGR3 early growth response 3 0.163111
MAOB monoamine oxidase B 0.162908
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 0.162707
EZR ezrin 0.161523
DCXR dicarbonyl/L-xylulose reductase 0.160021
CBS cystathionine-beta-synthase 0.1487
MARS methionyl-tRNA synthetase 0.141198
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.140707
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.138498
GRN granulin 0.137097
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 0.135813
PDE4B phosphodiesterase 4B, cAMP-specific 0.13555
CYS1 cystin 1 0.134787
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.134641
SIX5 SIX homeobox 5 0.134066
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.133528
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.132386
DRD3 dopamine receptor D3 0.132069
SIRT3 sirtuin 3 0.128759
ARSH arylsulfatase family, member H 0.128741
IFNB1 interferon, beta 1, fibroblast 0.128671
SP6 Sp6 transcription factor 0.12799
INA internexin neuronal intermediate filament protein, alpha 0.124786
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.124786
MUT methylmalonyl CoA mutase 0.12091
FOS FBJ murine osteosarcoma viral oncogene homolog 0.119908
POLK polymerase (DNA directed) kappa 0.115134
ZDHHC23 zinc finger, DHHC-type containing 23 0.115115
TGFB3 transforming growth factor, beta 3 0.114251
ETV3 ets variant 3 0.113908
LRP5 low density lipoprotein receptor-related protein 5 0.113046
CAV1 caveolin 1, caveolae protein, 22kDa 0.112381
RNASE3 ribonuclease, RNase A family, 3 0.107003
ADA adenosine deaminase 0.104287
HAMP hepcidin antimicrobial peptide 0.08695
FMR1 fragile X mental retardation 1 0.086819
CLNK cytokine-dependent hematopoietic cell linker 0.086589
SHH sonic hedgehog 0.085495
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 0.085296
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.084996
RBMS1 RNA binding motif, single stranded interacting protein 1 0.084223
ECI1 enoyl-CoA delta isomerase 1 0.084223
IGLL5 immunoglobulin lambda-like polypeptide 5 0.084088
FBLIM1 filamin binding LIM protein 1 0.082801
CSN3 casein kappa 0.081571
RPIA ribose 5-phosphate isomerase A 0.080915
CXCL8 chemokine (C-X-C motif) ligand 8 0.079038
DLL1 delta-like 1 (Drosophila) 0.079003
TFG TRK-fused gene 0.077739
SARS seryl-tRNA synthetase 0.077633
LATS2 large tumor suppressor kinase 2 0.076787
SRR serine racemase 0.076467
SACS sacsin molecular chaperone 0.076431
TGFB1 transforming growth factor, beta 1 0.07636
GP2 glycoprotein 2 (zymogen granule membrane) 0.075863
TRPC6 transient receptor potential cation channel, subfamily C, member 6 0.075721
RORA RAR-related orphan receptor A 0.075685
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 0.075043
TGFB2 transforming growth factor, beta 2 0.074506