severe pre-eclampsia Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A pre-eclampsia that has_symptom at least one of the following: SBP of 160mm HG or higher or DPB of 110mm HG or higher on 2 occasions at least 6 hours apart, proteinuria more than 5g in a 24-hour collection, pulmonary edema or cyanosis, oliguria, persistent headaches, epigastric pain and/or impaired liver function, thrombocytopenia, oligohydramnios, decreased fetal growth or placental abruption. (Human Disease Ontology, DOID_13129)
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Genes

219 genes co-occuring with the disease severe pre-eclampsia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PGF placental growth factor 1.70178
F5 coagulation factor V (proaccelerin, labile factor) 1.66916
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.62605
FLT1 fms-related tyrosine kinase 1 1.62381
LGALS13 lectin, galactoside-binding, soluble, 13 1.59519
F2 coagulation factor II (thrombin) 1.42849
PAPPA2 pappalysin 2 1.37032
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.30488
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 1.25254
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.23994
TTLL5 tubulin tyrosine ligase-like family member 5 1.23039
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.21955
HTRA4 HtrA serine peptidase 4 1.1473
PROS1 protein S (alpha) 1.10426
HP haptoglobin 1.09167
HPR haptoglobin-related protein 1.08495
ANKRD37 ankyrin repeat domain 37 1.05765
THBD thrombomodulin 1.00541
PLG plasminogen 1.00499
F3 coagulation factor III (thromboplastin, tissue factor) 0.9717
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 0.94078
LEP leptin 0.932898
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.89582
LNPEP leucyl/cystinyl aminopeptidase 0.883111
ALB albumin 0.869187
LGALS14 lectin, galactoside-binding, soluble, 14 0.849126
ADAM12 ADAM metallopeptidase domain 12 0.830279
CHURC1 churchill domain containing 1 0.808129
STOX1 storkhead box 1 0.786803
VSIG4 V-set and immunoglobulin domain containing 4 0.767985
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 0.759008
GCM1 glial cells missing homolog 1 (Drosophila) 0.74883
RDH13 retinol dehydrogenase 13 (all-trans/9-cis) 0.732596
ZFPL1 zinc finger protein-like 1 0.725311
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.718846
VWF von Willebrand factor 0.718443
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 0.70434
ACVR2A activin A receptor, type IIA 0.677504
NOS3 nitric oxide synthase 3 (endothelial cell) 0.676308
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.674315
KISS1 KiSS-1 metastasis-suppressor 0.669936
FN1 fibronectin 1 0.667152
CSH2 chorionic somatomammotropin hormone 2 0.653276
MIR210 microRNA 210 0.650113
IL6 interleukin 6 0.641433
EDN1 endothelin 1 0.637495
TNF tumor necrosis factor 0.632777
FSTL3 follistatin-like 3 (secreted glycoprotein) 0.623359
HLA-E major histocompatibility complex, class I, E 0.622967
AFP alpha-fetoprotein 0.622183
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.621792
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 0.619051
F8 coagulation factor VIII, procoagulant component 0.613965
CNN2 calponin 2 0.60303
VCAM1 vascular cell adhesion molecule 1 0.59913
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.59913
HLA-C major histocompatibility complex, class I, C 0.59874
MMP15 matrix metallopeptidase 15 (membrane-inserted) 0.594064
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.58939
IGFBP1 insulin-like growth factor binding protein 1 0.58433
SLCO4C1 solute carrier organic anion transporter family, member 4C1 0.571495
HLA-G major histocompatibility complex, class I, G 0.566831
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.549359
APOH apolipoprotein H (beta-2-glycoprotein I) 0.548583
NOMO1 NODAL modulator 1 0.547807
PMCH pro-melanin-concentrating hormone 0.542379
KLRC2 killer cell lectin-like receptor subfamily C, member 2 0.538118
SH3PXD2A SH3 and PX domains 2A 0.515725
HADH hydroxyacyl-CoA dehydrogenase 0.514956
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.513417
CRP C-reactive protein, pentraxin-related 0.508808
VEGFA vascular endothelial growth factor A 0.506507
SIGLEC6 sialic acid binding Ig-like lectin 6 0.506507
GPANK1 G patch domain and ankyrin repeats 1 0.479047
LEPR leptin receptor 0.473361
APEH acylaminoacyl-peptide hydrolase 0.473361
LHB luteinizing hormone beta polypeptide 0.466172
CST3 cystatin C 0.46466
C5AR1 complement component 5a receptor 1 0.46466
DUSP9 dual specificity phosphatase 9 0.461261
LOC102724852 uncharacterized LOC102724852 0.457109
LCN2 lipocalin 2 0.445052
SELE selectin E 0.442795
SDC1 syndecan 1 0.442418
ICAM1 intercellular adhesion molecule 1 0.432646
NOTCH1 notch 1 0.416896
INHA inhibin, alpha 0.412405
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 0.399707
LVRN laeverin 0.392629
NAAA N-acylethanolamine acid amidase 0.389653
GPX5 glutathione peroxidase 5 0.381481
GPX4 glutathione peroxidase 4 0.378514
FGR FGR proto-oncogene, Src family tyrosine kinase 0.372217
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 0.367779
LGALS1 lectin, galactoside-binding, soluble, 1 0.363716
GPX1 glutathione peroxidase 1 0.363347
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 0.363347
IL16 interleukin 16 0.357077
MMP24 matrix metallopeptidase 24 (membrane-inserted) 0.35082
CP ceruloplasmin (ferroxidase) 0.345308
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.345308
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 0.338341
ACE angiotensin I converting enzyme 0.33651
KLRC3 killer cell lectin-like receptor subfamily C, member 3 0.334681
TFPI2 tissue factor pathway inhibitor 2 0.332852
PLAU plasminogen activator, urokinase 0.328469
ANG angiogenin, ribonuclease, RNase A family, 5 0.322637
KLRC1 killer cell lectin-like receptor subfamily C, member 1 0.322273
SPATA21 spermatogenesis associated 21 0.317182
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.312102
PLAT plasminogen activator, tissue 0.311377
AKR1C3 aldo-keto reductase family 1, member C3 0.309928
MMP17 matrix metallopeptidase 17 (membrane-inserted) 0.309204
COMMD1 copper metabolism (Murr1) domain containing 1 0.30848
NPPA natriuretic peptide A 0.304864
GSTP1 glutathione S-transferase pi 1 0.29118
IL1B interleukin 1, beta 0.290821
HPD 4-hydroxyphenylpyruvate dioxygenase 0.289386
F2R coagulation factor II (thrombin) receptor 0.287952
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.286877
FAM132A family with sequence similarity 132, member A 0.281153
ARR3 arrestin 3, retinal (X-arrestin) 0.277584
LDHA lactate dehydrogenase A 0.273308
HLA-A major histocompatibility complex, class I, A 0.272953
CTHRC1 collagen triple helix repeat containing 1 0.264785
CRHBP corticotropin releasing hormone binding protein 0.261952
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.261952
MMP9 matrix metallopeptidase 9 0.260538
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 0.253479
FAS Fas cell surface death receptor 0.253127
IGF1 insulin-like growth factor 1 (somatomedin C) 0.24715
BIN2 bridging integrator 2 0.243995
GSTA1 glutathione S-transferase alpha 1 0.23945
IDO1 indoleamine 2,3-dioxygenase 1 0.234573
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 0.234225
VAMP8 vesicle-associated membrane protein 8 0.230063
PPT2 palmitoyl-protein thioesterase 2 0.224196
MMP28 matrix metallopeptidase 28 0.222136
CPB2 carboxypeptidase B2 (plasma) 0.221793
SENP1 SUMO1/sentrin specific peptidase 1 0.220766
PRSS8 protease, serine, 8 0.215653
SEBOX SEBOX homeobox 0.215314
PROC protein C (inactivator of coagulation factors Va and VIIIa) 0.211597
AHSP alpha hemoglobin stabilizing protein 0.211261
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.208914
WWTR1 WW domain containing transcription regulator 1 0.20658
BHLHE40 basic helix-loop-helix family, member e40 0.205254
HSPA4 heat shock 70kDa protein 4 0.199681
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.199356
UTS2 urotensin 2 0.199033
FLT4 fms-related tyrosine kinase 4 0.19742
LPAR2 lysophosphatidic acid receptor 2 0.196779
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.196779
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.194865
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 0.191719
PEX10 peroxisomal biogenesis factor 10 0.191719
KAT8 K(lysine) acetyltransferase 8 0.189551
FASLG Fas ligand (TNF superfamily, member 6) 0.188938
ALPPL2 alkaline phosphatase, placental-like 2 0.188938
ALPP alkaline phosphatase, placental 0.188632
ALPL alkaline phosphatase, liver/bone/kidney 0.188326
ITGA1 integrin, alpha 1 0.186811
FBXW2 F-box and WD repeat domain containing 2 0.18621
PARVA parvin, alpha 0.178403
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.175679
ADM adrenomedullin 0.174354
ADORA2B adenosine A2b receptor 0.174354
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.172038
CD46 CD46 molecule, complement regulatory protein 0.169812
FST follistatin 0.169571
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.168617
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.168381
JUNB jun B proto-oncogene 0.168148
MMP8 matrix metallopeptidase 8 0.167452
UMOD uromodulin 0.166768
MANBA mannosidase, beta A, lysosomal 0.163523
RERE arginine-glutamic acid dipeptide (RE) repeats 0.163317
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 0.162306
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.162109
RAET1E retinoic acid early transcript 1E 0.159838
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.15948
EGLN2 egl-9 family hypoxia-inducible factor 2 0.159302
PNMA1 paraneoplastic Ma antigen 1 0.145113
CGB7 chorionic gonadotropin, beta polypeptide 7 0.144979
CGB5 chorionic gonadotropin, beta polypeptide 5 0.144954
CORIN corin, serine peptidase 0.144948
FAM155B family with sequence similarity 155, member B 0.144918
SUOX sulfite oxidase 0.144817
TGFB3 transforming growth factor, beta 3 0.144681
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.14462
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 0.14462
CGB chorionic gonadotropin, beta polypeptide 0.14462
ACADVL acyl-CoA dehydrogenase, very long chain 0.14462
CGB8 chorionic gonadotropin, beta polypeptide 8 0.144611
CPT2 carnitine palmitoyltransferase 2 0.144593
LAMP3 lysosomal-associated membrane protein 3 0.144571
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 0.144498
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.144469
TALDO1 transaldolase 1 0.144373
LY75 lymphocyte antigen 75 0.144234
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 0.144197
PIGF phosphatidylinositol glycan anchor biosynthesis, class F 0.143978
CFI complement factor I 0.143951
ERAP1 endoplasmic reticulum aminopeptidase 1 0.143658
BBS1 Bardet-Biedl syndrome 1 0.143658
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.143509
HSPA1B heat shock 70kDa protein 1B 0.143355
TREM1 triggering receptor expressed on myeloid cells 1 0.143278
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.142954
CD8B CD8b molecule 0.142913
ERVW-1 endogenous retrovirus group W, member 1 0.142806
HES5 hes family bHLH transcription factor 5 0.142517
GPR182 G protein-coupled receptor 182 0.142277
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 0.141915
TIMP1 TIMP metallopeptidase inhibitor 1 0.141586
TTR transthyretin 0.141576
GSTA3 glutathione S-transferase alpha 3 0.14134
GSTA2 glutathione S-transferase alpha 2 0.141307
GSTA4 glutathione S-transferase alpha 4 0.141274