severe acute respiratory syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A viral infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia. (Human Disease Ontology, DOID_2945)
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Genes

181 genes co-occuring with the disease severe acute respiratory syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CDSN corneodesmosin 2.77573
ACE2 angiotensin I converting enzyme 2 2.70747
SH2D3C SH2 domain containing 3C 1.78759
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 1.70042
SH2D3A SH2 domain containing 3A 1.65879
CLEC4M C-type lectin domain family 4, member M 1.50667
CTRL chymotrypsin-like 1.30751
CXCL10 chemokine (C-X-C motif) ligand 10 1.26255
FBXO17 F-box protein 17 1.09419
TMPRSS11A transmembrane protease, serine 11A 1.07194
CD209 CD209 molecule 1.05135
IRF3 interferon regulatory factor 3 1.04966
SENP6 SUMO1/sentrin specific peptidase 6 1.04293
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 1.04251
BATF2 basic leucine zipper transcription factor, ATF-like 2 1.02355
RPS19BP1 ribosomal protein S19 binding protein 1 1.02313
CD4 CD4 molecule 1.00499
ATF6B activating transcription factor 6 beta 0.979268
PPIH peptidylprolyl isomerase H (cyclophilin H) 0.950352
IFNA1 interferon, alpha 1 0.86018
FGL2 fibrinogen-like 2 0.859362
STAT1 signal transducer and activator of transcription 1, 91kDa 0.850764
CAPN7 calpain 7 0.828229
TMPRSS11E transmembrane protease, serine 11E 0.825358
CTSL cathepsin L 0.791721
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 0.788033
SP8 Sp8 transcription factor 0.788033
USP33 ubiquitin specific peptidase 33 0.765535
TRAF3 TNF receptor-associated factor 3 0.764718
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 0.763086
CXCL9 chemokine (C-X-C motif) ligand 9 0.747204
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.740299
MAVS mitochondrial antiviral signaling protein 0.738676
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.732596
TMPRSS2 transmembrane protease, serine 2 0.728547
KRT39 keratin 39, type I 0.728143
FKBP1C FK506 binding protein 1C 0.717232
CD68 CD68 molecule 0.708767
MID2 midline 2 0.706754
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.701526
FKBP1B FK506 binding protein 1B, 12.6 kDa 0.698715
CCL2 chemokine (C-C motif) ligand 2 0.67312
HRC histidine rich calcium binding protein 0.661594
CRP C-reactive protein, pentraxin-related 0.650903
FAIM Fas apoptotic inhibitory molecule 0.650508
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 0.647348
IFNB1 interferon, beta 1, fibroblast 0.645375
IGHV3-30 immunoglobulin heavy variable 3-30 0.640251
ANPEP alanyl (membrane) aminopeptidase 0.622967
MX1 MX dynamin-like GTPase 1 0.616703
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.594064
ADAM17 ADAM metallopeptidase domain 17 0.593285
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.592895
TNF tumor necrosis factor 0.589779
CCL3 chemokine (C-C motif) ligand 3 0.58433
CD79A CD79a molecule, immunoglobulin-associated alpha 0.574605
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.572273
CWC15 CWC15 spliceosome-associated protein 0.569163
ICAM3 intercellular adhesion molecule 3 0.561392
ERVW-1 endogenous retrovirus group W, member 1 0.552463
NFIL3 nuclear factor, interleukin 3 regulated 0.548583
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.547032
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.540055
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 0.529608
OR6B2 olfactory receptor, family 6, subfamily B, member 2 0.52343
ATF6 activating transcription factor 6 0.521888
GAS2 growth arrest-specific 2 0.511496
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 0.511496
CCL5 chemokine (C-C motif) ligand 5 0.511112
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 0.509959
ADH6 alcohol dehydrogenase 6 (class V) 0.504973
SARS seryl-tRNA synthetase 0.496939
TMPRSS11D transmembrane protease, serine 11D 0.492359
CKLF chemokine-like factor 0.479047
HLA-A major histocompatibility complex, class I, A 0.479047
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.478668
SRPK1 SRSF protein kinase 1 0.474498
ACE angiotensin I converting enzyme 0.47374
THAP3 THAP domain containing, apoptosis associated protein 3 0.46655
ISG15 ISG15 ubiquitin-like modifier 0.457109
FURIN furin (paired basic amino acid cleaving enzyme) 0.445805
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.443171
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.43753
PCBP2 poly(rC) binding protein 2 0.435275
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.422515
HLA-C major histocompatibility complex, class I, C 0.421016
TMEM27 transmembrane protein 27 0.420266
MIR98 microRNA 98 0.412779
TSPO translocator protein (18kDa) 0.406425
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.405305
TMPRSS13 transmembrane protease, serine 13 0.403811
UBE2H ubiquitin-conjugating enzyme E2H 0.399707
CXCL8 chemokine (C-X-C motif) ligand 8 0.398589
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 0.397471
SIM1 single-minded family bHLH transcription factor 1 0.394863
ATF5 activating transcription factor 5 0.389653
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.387423
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 0.379626
TANK TRAF family member-associated NFKB activator 0.378514
UBA1 ubiquitin-like modifier activating enzyme 1 0.364085
ALB albumin 0.364085
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 0.360395
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.359657
IRF7 interferon regulatory factor 7 0.348246
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.344941
GUK1 guanylate kinase 1 0.34384
CCR7 chemokine (C-C motif) receptor 7 0.340173
SAA2 serum amyloid A2 0.339806
TCEA1 transcription elongation factor A (SII), 1 0.337975
ERN1 endoplasmic reticulum to nucleus signaling 1 0.337608
FOXJ1 forkhead box J1 0.335046
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.334681
C19ORF70 chromosome 19 open reading frame 70 0.331756
GBP1 guanylate binding protein 1, interferon-inducible 0.328834
DPP4 dipeptidyl-peptidase 4 0.326281
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.324094
CD86 CD86 molecule 0.318999
TGFB1 transforming growth factor, beta 1 0.317182
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 0.316092
MLYCD malonyl-CoA decarboxylase 0.315366
RNH1 ribonuclease/angiogenin inhibitor 1 0.312827
F3 coagulation factor III (thromboplastin, tissue factor) 0.311377
C1QB complement component 1, q subcomponent, B chain 0.300533
EPS15 epidermal growth factor receptor pathway substrate 15 0.298731
CASP5 caspase 5, apoptosis-related cysteine peptidase 0.295851
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.289386
PDS5B PDS5 cohesin associated factor B 0.285444
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 0.278297
RGMB repulsive guidance molecule family member b 0.277584
ATG5 autophagy related 5 0.269398
SIM2 single-minded family bHLH transcription factor 2 0.263014
PER1 period circadian clock 1 0.261245
IL6 interleukin 6 0.259124
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.251015
ARF1 ADP-ribosylation factor 1 0.248554
CFAP74 cilia and flagella associated protein 74 0.244696
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.243295
THEM5 thioesterase superfamily member 5 0.241895
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.241546
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 0.23945
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 0.235964
ACRV1 acrosomal vesicle protein 1 0.234225
FBL fibrillarin 0.232836
TXNDC9 thioredoxin domain containing 9 0.228679
TMEM173 transmembrane protein 173 0.227642
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.226607
COL2A1 collagen, type II, alpha 1 0.215653
LAMP1 lysosomal-associated membrane protein 1 0.214636
PROS1 protein S (alpha) 0.212608
FANCB Fanconi anemia, complementation group B 0.212608
DEDD death effector domain containing 0.209248
IFNL1 interferon, lambda 1 0.206913
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 0.204593
PDIA3 protein disulfide isomerase family A, member 3 0.204593
OSTC oligosaccharyltransferase complex subunit (non-catalytic) 0.203604
MSR1 macrophage scavenger receptor 1 0.20229
SZRD1 SUZ RNA binding domain containing 1 0.200331
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.197099
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.192344
SEPT4 septin 4 0.192031
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.191719
EEA1 early endosome antigen 1 0.186811
CD3D CD3d molecule, delta (CD3-TCR complex) 0.18472
FBLL1 fibrillarin-like 1 0.184424
IL12RB1 interleukin 12 receptor, beta 1 0.181222
IL1B interleukin 1, beta 0.178682
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.175947
BAG3 BCL2-associated athanogene 3 0.175679
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.175679
GSTA3 glutathione S-transferase alpha 3 0.173832
NPEPPS aminopeptidase puromycin sensitive 0.173571
MASP2 mannan-binding lectin serine peptidase 2 0.173057
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 0.173057
GSTA2 glutathione S-transferase alpha 2 0.172799
GSTA4 glutathione S-transferase alpha 4 0.172038
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.171785
GSTA1 glutathione S-transferase alpha 1 0.168381
IL4 interleukin 4 0.165874
CALR calreticulin 0.165435
ISG20 interferon stimulated exonuclease gene 20kDa 0.163317
ARSB arylsulfatase B 0.15948