serine-type endopeptidase activity Gene Set

Dataset GO Molecular Function Annotations
Category structural or functional annotations
Type molecular function
Description Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). (Gene Ontology, GO_0004252)
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146 genes performing the serine-type endopeptidase activity molecular function from the curated GO Molecular Function Annotations dataset.

Symbol Name
ACR acrosin
APEH acylaminoacyl-peptide hydrolase
AZU1 azurocidin 1
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
C2 complement component 2
CELA1 chymotrypsin-like elastase family, member 1
CELA2A chymotrypsin-like elastase family, member 2A
CELA2B chymotrypsin-like elastase family, member 2B
CELA3A chymotrypsin-like elastase family, member 3A
CELA3B chymotrypsin-like elastase family, member 3B
CFB complement factor B
CFD complement factor D (adipsin)
CFI complement factor I
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
CMA1 chymase 1, mast cell
CORIN corin, serine peptidase
CTRB2 chymotrypsinogen B2
CTRC chymotrypsin C (caldecrin)
CTRL chymotrypsin-like
CTSC cathepsin C
CTSG cathepsin G
CTSH cathepsin H
DPP4 dipeptidyl-peptidase 4
ELANE elastase, neutrophil expressed
F10 coagulation factor X
F11 coagulation factor XI
F12 coagulation factor XII (Hageman factor)
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F8 coagulation factor VIII, procoagulant component
F9 coagulation factor IX
FAP fibroblast activation protein, alpha
FURIN furin (paired basic amino acid cleaving enzyme)
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
GZMK granzyme K (granzyme 3; tryptase II)
GZMM granzyme M (lymphocyte met-ase 1)
HABP2 hyaluronan binding protein 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HGFAC HGF activator
HPN hepsin
HTRA1 HtrA serine peptidase 1
HTRA2 HtrA serine peptidase 2
HTRA3 HtrA serine peptidase 3
HTRA4 HtrA serine peptidase 4
KLK1 kallikrein 1
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK12 kallikrein-related peptidase 12
KLK13 kallikrein-related peptidase 13
KLK14 kallikrein-related peptidase 14
KLK15 kallikrein-related peptidase 15
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KLK4 kallikrein-related peptidase 4
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
KLK7 kallikrein-related peptidase 7
KLK8 kallikrein-related peptidase 8
KLK9 kallikrein-related peptidase 9
KLKB1 kallikrein B, plasma (Fletcher factor) 1
LONP1 lon peptidase 1, mitochondrial
LONP2 lon peptidase 2, peroxisomal
LTF lactotransferrin
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MASP2 mannan-binding lectin serine peptidase 2
MBTPS1 membrane-bound transcription factor peptidase, site 1
MMP2 matrix metallopeptidase 2
MMP8 matrix metallopeptidase 8
MST1 macrophage stimulating 1
MST1L macrophage stimulating 1-like
OVCH1 ovochymase 1
PARL presenilin associated, rhomboid-like
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PCSK4 proprotein convertase subtilisin/kexin type 4
PCSK5 proprotein convertase subtilisin/kexin type 5
PCSK6 proprotein convertase subtilisin/kexin type 6
PCSK7 proprotein convertase subtilisin/kexin type 7
PCSK9 proprotein convertase subtilisin/kexin type 9
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLG plasminogen
PREP prolyl endopeptidase
PREPL prolyl endopeptidase-like
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PRSS1 protease, serine, 1 (trypsin 1)
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PRSS2 protease, serine, 2 (trypsin 2)
PRSS21 protease, serine, 21 (testisin)
PRSS22 protease, serine, 22
PRSS27 protease, serine 27
PRSS3 protease, serine, 3
PRSS33 protease, serine, 33
PRSS36 protease, serine, 36
PRSS37 protease, serine, 37
PRSS38 protease, serine, 38
PRSS41 protease, serine, 41
PRSS42 protease, serine, 42
PRSS45 protease, serine, 45
PRSS46 protease, serine, 46
PRSS48 protease, serine, 48
PRSS50 protease, serine, 50
PRSS53 protease, serine, 53
PRSS54 protease, serine, 54
PRSS55 protease, serine, 55
PRSS56 protease, serine, 56
PRSS57 protease, serine, 57
PRSS58 protease, serine, 58
PRSS8 protease, serine, 8
PRTN3 proteinase 3
RHBDD1 rhomboid domain containing 1
RHBDD2 rhomboid domain containing 2
RHBDD3 rhomboid domain containing 3
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHBDL1 rhomboid, veinlet-like 1 (Drosophila)
RHBDL2 rhomboid, veinlet-like 2 (Drosophila)
RHBDL3 rhomboid, veinlet-like 3 (Drosophila)
ST14 suppression of tumorigenicity 14 (colon carcinoma)
TMPRSS11A transmembrane protease, serine 11A
TMPRSS11B transmembrane protease, serine 11B
TMPRSS11D transmembrane protease, serine 11D
TMPRSS11E transmembrane protease, serine 11E
TMPRSS11F transmembrane protease, serine 11F
TMPRSS12 transmembrane (C-terminal) protease, serine 12
TMPRSS13 transmembrane protease, serine 13
TMPRSS15 transmembrane protease, serine 15
TMPRSS2 transmembrane protease, serine 2
TMPRSS3 transmembrane protease, serine 3
TMPRSS4 transmembrane protease, serine 4
TMPRSS5 transmembrane protease, serine 5
TMPRSS6 transmembrane protease, serine 6
TMPRSS7 transmembrane protease, serine 7
TMPRSS9 transmembrane protease, serine 9
TPP1 tripeptidyl peptidase I
TPP2 tripeptidyl peptidase II
TPSAB1 tryptase alpha/beta 1
TPSD1 tryptase delta 1
TPSG1 tryptase gamma 1
TYSND1 trypsin domain containing 1