senescence-associated heterochromatin focus Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes. (Gene Ontology, GO_0035985)
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Genes

56 proteins co-occuring with the senescence-associated heterochromatin focus cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
ASF1A anti-silencing function 1A histone chaperone 1.6001
UBN2 ubinuclein 2 1.42655
CDKN2A cyclin-dependent kinase inhibitor 2A 0.984393
ZNF148 zinc finger protein 148 0.913909
ZMYND11 zinc finger, MYND-type containing 11 0.830007
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.768171
CBX3 chromobox homolog 3 0.760887
DPY30 dpy-30 homolog (C. elegans) 0.72258
HMGA2 high mobility group AT-hook 2 0.702185
UBN1 ubinuclein 1 0.683771
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.634159
MIR210 microRNA 210 0.62393
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.615437
HBP1 HMG-box transcription factor 1 0.610355
TP53 tumor protein p53 0.604017
TBX2 T-box 2 0.585942
TBX3 T-box 3 0.544
RB1 retinoblastoma 1 0.542352
SIRT2 sirtuin 2 0.529618
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 0.51694
H2AFY H2A histone family, member Y 0.492157
WNT2 wingless-type MMTV integration site family member 2 0.484886
EP400 E1A binding protein p400 0.484483
SIRT1 sirtuin 1 0.477636
H3F3B H3 histone, family 3B (H3.3B) 0.454816
H3F3A H3 histone, family 3A 0.454816
RUVBL2 RuvB-like AAA ATPase 2 0.446069
BRCA1 breast cancer 1, early onset 0.428284
CFB complement factor B 0.42396
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 0.423174
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 0.383895
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.358228
HRAS Harvey rat sarcoma viral oncogene homolog 0.33511
PRDX1 peroxiredoxin 1 0.295489
NAMPT nicotinamide phosphoribosyltransferase 0.274835
CBX5 chromobox homolog 5 0.266042
HDAC4 histone deacetylase 4 0.259109
HIST1H2AM histone cluster 1, H2am 0.24424
H2AFJ H2A histone family, member J 0.24424
HIST1H2AD histone cluster 1, H2ad 0.24424
HIST1H2AJ histone cluster 1, H2aj 0.24424
HIST1H2AH histone cluster 1, H2ah 0.243879
HIST1H2AG histone cluster 1, H2ag 0.242797
H2AFY2 H2A histone family, member Y2 0.241356
HIST1H2AE histone cluster 1, H2ae 0.240636
HIST1H2AB histone cluster 1, H2ab 0.240636
H2AFV H2A histone family, member V 0.240276
H2AFB1 H2A histone family, member B1 0.23776
H2AFB2 H2A histone family, member B2 0.234533
HMGA1 high mobility group AT-hook 1 0.230601
SIRT3 sirtuin 3 0.213322
LMNB1 lamin B1 0.194371
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.189539
HDAC3 histone deacetylase 3 0.17687
DAXX death-domain associated protein 0.171673
SQSTM1 sequestosome 1 0.16298