seneciphylline-4822 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the seneciphylline-4822 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGO4 argonaute RISC catalytic component 4
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANK1 ankyrin 1, erythrocytic
BTF3P11 basic transcription factor 3 pseudogene 11
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C22ORF46 chromosome 22 open reading frame 46
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CALD1 caldesmon 1
CARTPT CART prepropeptide
CBX8 chromobox homolog 8
CD244 CD244 molecule, natural killer cell receptor 2B4
CD68 CD68 molecule
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CES3 carboxylesterase 3
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CMA1 chymase 1, mast cell
CNOT2 CCR4-NOT transcription complex, subunit 2
COMMD4 COMM domain containing 4
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
EN2 engrailed homeobox 2
FGF1 fibroblast growth factor 1 (acidic)
FRMD4B FERM domain containing 4B
FSCN3 fascin actin-bundling protein 3, testicular
FXYD5 FXYD domain containing ion transport regulator 5
FZD9 frizzled class receptor 9
GAMT guanidinoacetate N-methyltransferase
GJB3 gap junction protein, beta 3, 31kDa
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GOLGA2P5 golgin A2 pseudogene 5
GPR161 G protein-coupled receptor 161
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GSTA3 glutathione S-transferase alpha 3
GSTP1 glutathione S-transferase pi 1
HGFAC HGF activator
HIST1H1E histone cluster 1, H1e
HOXA4 homeobox A4
HOXA7 homeobox A7
HOXC8 homeobox C8
IBSP integrin-binding sialoprotein
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGLJ3 immunoglobulin lambda joining 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
JMJD6 jumonji domain containing 6
JPH3 junctophilin 3
KPNA5 karyopherin alpha 5 (importin alpha 6)
KSR1 kinase suppressor of ras 1
LAMA4 laminin, alpha 4
LCT lactase
LIF leukemia inhibitory factor
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOC100286895 cell division cycle 27 homolog pseudogene
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPK7 mitogen-activated protein kinase 7
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MED25 mediator complex subunit 25
MEF2D myocyte enhancer factor 2D
MTRF1L mitochondrial translational release factor 1-like
MYEF2 myelin expression factor 2
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
N4BP2L2-IT2 N4BPL2 intronic transcript 2
OASL 2'-5'-oligoadenylate synthetase-like
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OVOL2 ovo-like zinc finger 2
PCDHGA10 protocadherin gamma subfamily A, 10
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PILRA paired immunoglobin-like type 2 receptor alpha
POU2F3 POU class 2 homeobox 3
PRB3 proline-rich protein BstNI subfamily 3
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTPRB protein tyrosine phosphatase, receptor type, B
PURG purine-rich element binding protein G
RGS1 regulator of G-protein signaling 1
RORC RAR-related orphan receptor C
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
RTEL1 regulator of telomere elongation helicase 1
RUNX1 runt-related transcription factor 1
SLC25A30 solute carrier family 25, member 30
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPTBN2 spectrin, beta, non-erythrocytic 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SSX3 synovial sarcoma, X breakpoint 3
TIMP3 TIMP metallopeptidase inhibitor 3
TPMT thiopurine S-methyltransferase
WDR76 WD repeat domain 76
WNT1 wingless-type MMTV integration site family, member 1
WT1-AS WT1 antisense RNA

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AP1AR adaptor-related protein complex 1 associated regulatory protein
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
ARHGAP12 Rho GTPase activating protein 12
ASB7 ankyrin repeat and SOCS box containing 7
ATAD5 ATPase family, AAA domain containing 5
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C1GALT1C1 C1GALT1-specific chaperone 1
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
CDC73 cell division cycle 73
CEP70 centrosomal protein 70kDa
CHUK conserved helix-loop-helix ubiquitous kinase
CLDN15 claudin 15
CLDND1 claudin domain containing 1
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
COCH cochlin
COPS5 COP9 signalosome subunit 5
CRABP1 cellular retinoic acid binding protein 1
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CRYZL1 crystallin, zeta (quinone reductase)-like 1
CTNNBIP1 catenin, beta interacting protein 1
DCAF17 DDB1 and CUL4 associated factor 17
DENND4C DENN/MADD domain containing 4C
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNA2 DNA replication helicase/nuclease 2
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DTWD1 DTW domain containing 1
ECHDC1 ethylmalonyl-CoA decarboxylase 1
EMC2 ER membrane protein complex subunit 2
ETAA1 Ewing tumor-associated antigen 1
FAIM Fas apoptotic inhibitory molecule
FBXO5 F-box protein 5
FZD6 frizzled class receptor 6
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
HCFC2 host cell factor C2
HEATR3 HEAT repeat containing 3
HIRA histone cell cycle regulator
IMPACT impact RWD domain protein
IMPAD1 inositol monophosphatase domain containing 1
KCTD9 potassium channel tetramerization domain containing 9
KIAA0895 KIAA0895
KIF14 kinesin family member 14
LMCD1 LIM and cysteine-rich domains 1
LOC257152 uncharacterized LOC257152
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MED4 mediator complex subunit 4
MOCS2 molybdenum cofactor synthesis 2
MORC3 MORC family CW-type zinc finger 3
MTCL1 microtubule crosslinking factor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit
NECAP1 NECAP endocytosis associated 1
NLK nemo-like kinase
NNT nicotinamide nucleotide transhydrogenase
NR1D2 nuclear receptor subfamily 1, group D, member 2
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PANX1 pannexin 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCNXL4 pecanex-like 4 (Drosophila)
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PRMT3 protein arginine methyltransferase 3
PRSS16 protease, serine, 16 (thymus)
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RAD51AP1 RAD51 associated protein 1
RNF11 ring finger protein 11
RNF146 ring finger protein 146
RNF38 ring finger protein 38
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SKA1 spindle and kinetochore associated complex subunit 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
SNIP1 Smad nuclear interacting protein 1
STXBP3 syntaxin binding protein 3
SYTL2 synaptotagmin-like 2
TGDS TDP-glucose 4,6-dehydratase
TMEM30A transmembrane protein 30A
TRAPPC13 trafficking protein particle complex 13
TRAPPC2 trafficking protein particle complex 2
TRIM5 tripartite motif containing 5
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TTC17 tetratricopeptide repeat domain 17
USP6NL USP6 N-terminal like
VCPKMT valosin containing protein lysine (K) methyltransferase
YIPF5 Yip1 domain family, member 5
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZNF430 zinc finger protein 430
ZNF586 zinc finger protein 586
ZNF654 zinc finger protein 654
ZNF816 zinc finger protein 816
ZSCAN16 zinc finger and SCAN domain containing 16
ZSCAN26 zinc finger and SCAN domain containing 26