semustine-7540 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the semustine-7540 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAM17 ADAM metallopeptidase domain 17
ADAP1 ArfGAP with dual PH domains 1
AFAP1 actin filament associated protein 1
AFF2 AF4/FMR2 family, member 2
AIRE autoimmune regulator
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATXN8OS ATXN8 opposite strand (non-protein coding)
BBS9 Bardet-Biedl syndrome 9
BIN1 bridging integrator 1
BTN2A1 butyrophilin, subfamily 2, member A1
BTN2A3P butyrophilin, subfamily 2, member A3, pseudogene
CA5BP1 carbonic anhydrase VB pseudogene 1
CCDC40 coiled-coil domain containing 40
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CPA4 carboxypeptidase A4
CTBS chitobiase, di-N-acetyl-
CTIF CBP80/20-dependent translation initiation factor
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DOCK6 dedicator of cytokinesis 6
EN2 engrailed homeobox 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ETV5 ets variant 5
FAM134B family with sequence similarity 134, member B
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GALE UDP-galactose-4-epimerase
GCLM glutamate-cysteine ligase, modifier subunit
HABP4 hyaluronan binding protein 4
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IL15RA interleukin 15 receptor, alpha
ISG20 interferon stimulated exonuclease gene 20kDa
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIAA0513 KIAA0513
KLF2 Kruppel-like factor 2
KRIT1 KRIT1, ankyrin repeat containing
LAMP1 lysosomal-associated membrane protein 1
LMF1 lipase maturation factor 1
LMO4 LIM domain only 4
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MED28 mediator complex subunit 28
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MTM1 myotubularin 1
NUPR1 nuclear protein, transcriptional regulator, 1
ONECUT2 one cut homeobox 2
OSGIN1 oxidative stress induced growth inhibitor 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PDLIM5 PDZ and LIM domain 5
PGBD5 piggyBac transposable element derived 5
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PPT2 palmitoyl-protein thioesterase 2
PSD4 pleckstrin and Sec7 domain containing 4
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RABGAP1 RAB GTPase activating protein 1
RARA retinoic acid receptor, alpha
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RFPL2 ret finger protein-like 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RUFY3 RUN and FYVE domain containing 3
SDC3 syndecan 3
SGSM3 small G protein signaling modulator 3
SH3BP2 SH3-domain binding protein 2
SIK3 SIK family kinase 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMIM14 small integral membrane protein 14
SQSTM1 sequestosome 1
STK24 serine/threonine kinase 24
STOML1 stomatin (EPB72)-like 1
SUGP1 SURP and G patch domain containing 1
TES testin LIM domain protein
TK2 thymidine kinase 2, mitochondrial
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM16 tripartite motif containing 16
TRIO trio Rho guanine nucleotide exchange factor
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSC22D4 TSC22 domain family, member 4
TXNRD1 thioredoxin reductase 1
UBB ubiquitin B
ZNF205 zinc finger protein 205
ZNF45 zinc finger protein 45
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADAP2 ArfGAP with dual PH domains 2
ADCY6 adenylate cyclase 6
AHCTF1 AT hook containing transcription factor 1
ALOX15 arachidonate 15-lipoxygenase
ANP32A-IT1 ANP32A intronic transcript 1
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BHLHB9 basic helix-loop-helix domain containing, class B, 9
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CES3 carboxylesterase 3
CLDN15 claudin 15
CLSTN2 calsyntenin 2
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CNTD2 cyclin N-terminal domain containing 2
COL9A2 collagen, type IX, alpha 2
CORO7 coronin 7
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DHRS1 dehydrogenase/reductase (SDR family) member 1
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DOCK1 dedicator of cytokinesis 1
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
ETV6 ets variant 6
ETV7 ets variant 7
FAM212B family with sequence similarity 212, member B
FKRP fukutin related protein
FLJ11710 uncharacterized protein FLJ11710
FZD2 frizzled class receptor 2
GLI3 GLI family zinc finger 3
GMEB1 glucocorticoid modulatory element binding protein 1
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H2AJ histone cluster 1, H2aj
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFI6 interferon, alpha-inducible protein 6
JADE1 jade family PHD finger 1
KIAA0125 KIAA0125
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL25 kelch-like family member 25
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LNPEP leucyl/cystinyl aminopeptidase
LRRC8E leucine rich repeat containing 8 family, member E
MAGEF1 melanoma antigen family F1
MAPK12 mitogen-activated protein kinase 12
NARFL nuclear prelamin A recognition factor-like
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NKX3-2 NK3 homeobox 2
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PHC1 polyhomeotic homolog 1 (Drosophila)
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLXNB3 plexin B3
PORCN porcupine homolog (Drosophila)
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRODH proline dehydrogenase (oxidase) 1
PRPH peripherin
PRR15L proline rich 15-like
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTPRE protein tyrosine phosphatase, receptor type, E
PTTG3P pituitary tumor-transforming 3, pseudogene
RAB8B RAB8B, member RAS oncogene family
RNF126P1 ring finger protein 126 pseudogene 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF25 ring finger protein 25
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RSF1 remodeling and spacing factor 1
SALL2 spalt-like transcription factor 2
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SMAD7 SMAD family member 7
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SNX15 sorting nexin 15
SOAT2 sterol O-acyltransferase 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TAOK1 TAO kinase 1
TCTN1 tectonic family member 1
TIGD6 tigger transposable element derived 6
TMEM53 transmembrane protein 53
UBE2L6 ubiquitin-conjugating enzyme E2L 6
WLS wntless Wnt ligand secretion mediator
WWC2 WW and C2 domain containing 2
ZBTB48 zinc finger and BTB domain containing 48
ZFP69B ZFP69 zinc finger protein B
ZNF33B zinc finger protein 33B
ZNF358 zinc finger protein 358
ZNF362 zinc finger protein 362
ZNF646 zinc finger protein 646
ZNF767P zinc finger family member 767, pseudogene