semustine-7492 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the semustine-7492 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ADCK2 aarF domain containing kinase 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA10 annexin A10
APH1B APH1B gamma secretase subunit
ARG2 arginase 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
C1ORF56 chromosome 1 open reading frame 56
C9ORF156 chromosome 9 open reading frame 156
CA9 carbonic anhydrase IX
CACFD1 calcium channel flower domain containing 1
CBS cystathionine-beta-synthase
CDIP1 cell death-inducing p53 target 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPO centromere protein O
CGREF1 cell growth regulator with EF-hand domain 1
CLU clusterin
CNR2 cannabinoid receptor 2 (macrophage)
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
DDIT3 DNA-damage-inducible transcript 3
DHRS9 dehydrogenase/reductase (SDR family) member 9
DMTN dematin actin binding protein
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FAM214B family with sequence similarity 214, member B
FEM1B fem-1 homolog b (C. elegans)
FER fer (fps/fes related) tyrosine kinase
GABARAPL1 GABA(A) receptor-associated protein like 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GK glycerol kinase
HEMK1 HemK methyltransferase family member 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDS iduronate 2-sulfatase
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL15RA interleukin 15 receptor, alpha
ISL1 ISL LIM homeobox 1
JUND jun D proto-oncogene
KCTD15 potassium channel tetramerization domain containing 15
KIFC3 kinesin family member C3
KLHL25 kelch-like family member 25
LAMP1 lysosomal-associated membrane protein 1
LIG4 ligase IV, DNA, ATP-dependent
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAX MYC associated factor X
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NPHP1 nephronophthisis 1 (juvenile)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
NXPE3 neurexophilin and PC-esterase domain family, member 3
OSGIN1 oxidative stress induced growth inhibitor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PACS1 phosphofurin acidic cluster sorting protein 1
PHF7 PHD finger protein 7
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLK3 polo-like kinase 3
PLSCR4 phospholipid scramblase 4
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PXMP4 peroxisomal membrane protein 4, 24kDa
RNASEH2B ribonuclease H2, subunit B
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
STOML1 stomatin (EPB72)-like 1
STX7 syntaxin 7
SYNGR1 synaptogyrin 1
TCTN1 tectonic family member 1
TDRKH tudor and KH domain containing
TEX261 testis expressed 261
TMEM259 transmembrane protein 259
TPP1 tripeptidyl peptidase I
TRIM16 tripartite motif containing 16
UROD uroporphyrinogen decarboxylase
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDTC1 WD and tetratricopeptide repeats 1
ZBTB20 zinc finger and BTB domain containing 20
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF37BP zinc finger protein 37B, pseudogene
ZNF43 zinc finger protein 43
ZNF783 zinc finger family member 783
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADRB2 adrenoceptor beta 2, surface
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARPIN actin-related protein 2/3 complex inhibitor
ARRB1 arrestin, beta 1
ARSJ arylsulfatase family, member J
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ATAD2 ATPase family, AAA domain containing 2
ATAD5 ATPase family, AAA domain containing 5
ATAT1 alpha tubulin acetyltransferase 1
ATG10 autophagy related 10
BEX4 brain expressed, X-linked 4
BMP4 bone morphogenetic protein 4
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CD70 CD70 molecule
CHMP6 charged multivesicular body protein 6
CHN1 chimerin 1
CISH cytokine inducible SH2-containing protein
CLCN2 chloride channel, voltage-sensitive 2
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLSTN3 calsyntenin 3
COL9A3 collagen, type IX, alpha 3
CSRNP3 cysteine-serine-rich nuclear protein 3
CTGF connective tissue growth factor
DBF4B DBF4 zinc finger B
DCAF4 DDB1 and CUL4 associated factor 4
DENND2D DENN/MADD domain containing 2D
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPY19L2P2 DPY19L2 pseudogene 2
DUSP13 dual specificity phosphatase 13
FMO4 flavin containing monooxygenase 4
GBX2 gastrulation brain homeobox 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLB1L galactosidase, beta 1-like
GLI3 GLI family zinc finger 3
GMIP GEM interacting protein
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR137B G protein-coupled receptor 137B
H1F0 H1 histone family, member 0
HELLS helicase, lymphoid-specific
HHLA1 HERV-H LTR-associating 1
HIST1H1D histone cluster 1, H1d
HIST1H4C histone cluster 1, H4c
HLA-DMB major histocompatibility complex, class II, DM beta
HOXC10 homeobox C10
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGSF3 immunoglobulin superfamily, member 3
IL1B interleukin 1, beta
INE1 inactivation escape 1 (non-protein coding)
LOC730101 uncharacterized LOC730101
LRRK1 leucine-rich repeat kinase 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MMP10 matrix metallopeptidase 10
MX1 MX dynamin-like GTPase 1
MXD3 MAX dimerization protein 3
MYH15 myosin, heavy chain 15
MYLK myosin light chain kinase
NDE1 nudE neurodevelopment protein 1
NOD1 nucleotide-binding oligomerization domain containing 1
OR7A10 olfactory receptor, family 7, subfamily A, member 10
PARM1 prostate androgen-regulated mucin-like protein 1
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PHC1 polyhomeotic homolog 1 (Drosophila)
PID1 phosphotyrosine interaction domain containing 1
PLEKHA6 pleckstrin homology domain containing, family A member 6
PODNL1 podocan-like 1
PRF1 perforin 1 (pore forming protein)
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRPF38B pre-mRNA processing factor 38B
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PTX3 pentraxin 3, long
RHOBTB2 Rho-related BTB domain containing 2
RUSC2 RUN and SH3 domain containing 2
SCAI suppressor of cancer cell invasion
SCEL sciellin
SCRG1 stimulator of chondrogenesis 1
SDC3 syndecan 3
SLC25A40 solute carrier family 25, member 40
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNRPN small nuclear ribonucleoprotein polypeptide N
SP4 Sp4 transcription factor
SPATA7 spermatogenesis associated 7
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYNPO synaptopodin
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAOK1 TAO kinase 1
TM4SF5 transmembrane 4 L six family member 5
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRAIP TRAF interacting protein
TUBGCP5 tubulin, gamma complex associated protein 5
TXK TXK tyrosine kinase
WDR47 WD repeat domain 47
WDR76 WD repeat domain 76
ZBTB38 zinc finger and BTB domain containing 38
ZNF219 zinc finger protein 219
ZNF667 zinc finger protein 667