semustine-7487 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the semustine-7487 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
ADAM22 ADAM metallopeptidase domain 22
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
AK1 adenylate kinase 1
AKAP4 A kinase (PRKA) anchor protein 4
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARNT aryl hydrocarbon receptor nuclear translocator
BTBD7 BTB (POZ) domain containing 7
BTN2A2 butyrophilin, subfamily 2, member A2
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CD200 CD200 molecule
CD53 CD53 molecule
COL13A1 collagen, type XIII, alpha 1
CPA2 carboxypeptidase A2 (pancreatic)
CTSF cathepsin F
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DIO2 deiodinase, iodothyronine, type II
DNASE1 deoxyribonuclease I
EGR1 early growth response 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EPHA2 EPH receptor A2
EPHA3 EPH receptor A3
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FAM120C family with sequence similarity 120C
FEM1B fem-1 homolog b (C. elegans)
FLOT1 flotillin 1
FNDC3A fibronectin type III domain containing 3A
FNTB farnesyltransferase, CAAX box, beta
FOSL1 FOS-like antigen 1
GADD45G growth arrest and DNA-damage-inducible, gamma
GCLM glutamate-cysteine ligase, modifier subunit
GFI1 growth factor independent 1 transcription repressor
GPR135 G protein-coupled receptor 135
GPR176 G protein-coupled receptor 176
GRB10 growth factor receptor-bound protein 10
HFE hemochromatosis
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICOSLG inducible T-cell co-stimulator ligand
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
JUN jun proto-oncogene
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KRT24 keratin 24, type I
LOC390998 ribosomal protein L10 pseudogene
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MCAM melanoma cell adhesion molecule
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEF2D myocyte enhancer factor 2D
MLXIPL MLX interacting protein-like
NECAB2 N-terminal EF-hand calcium binding protein 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPIPB3 nuclear pore complex interacting protein family, member B3
OGFR opioid growth factor receptor
OSGIN1 oxidative stress induced growth inhibitor 1
PAX8 paired box 8
PCLO piccolo presynaptic cytomatrix protein
PEX16 peroxisomal biogenesis factor 16
PIDD1 p53-induced death domain protein 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
POU2F2 POU class 2 homeobox 2
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP5C protein phosphatase 5, catalytic subunit
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PSD4 pleckstrin and Sec7 domain containing 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RANBP3 RAN binding protein 3
RASAL1 RAS protein activator like 1 (GAP1 like)
RBBP9 retinoblastoma binding protein 9
RBM12B RNA binding motif protein 12B
SATB1 SATB homeobox 1
SETD8 SET domain containing (lysine methyltransferase) 8
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC39A9 solute carrier family 39, member 9
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SRRT serrate, RNA effector molecule
STK17A serine/threonine kinase 17a
STMN1 stathmin 1
TAOK2 TAO kinase 2
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TRIM16 tripartite motif containing 16
TRIM23 tripartite motif containing 23
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TXNRD1 thioredoxin reductase 1
VIM vimentin
YPEL1 yippee-like 1 (Drosophila)
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF532 zinc finger protein 532
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADGRB1 adhesion G protein-coupled receptor B1
AP3B2 adaptor-related protein complex 3, beta 2 subunit
ARC activity-regulated cytoskeleton-associated protein
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BAG4 BCL2-associated athanogene 4
BARX2 BARX homeobox 2
BEX4 brain expressed, X-linked 4
C10ORF95 chromosome 10 open reading frame 95
C2ORF54 chromosome 2 open reading frame 54
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAMK1D calcium/calmodulin-dependent protein kinase ID
CCP110 centriolar coiled coil protein 110kDa
CD48 CD48 molecule
CD82 CD82 molecule
CERS4 ceramide synthase 4
CNTN5 contactin 5
CST6 cystatin E/M
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DHRS3 dehydrogenase/reductase (SDR family) member 3
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
ETNK2 ethanolamine kinase 2
FAM110B family with sequence similarity 110, member B
FZD2 frizzled class receptor 2
GBP2 guanylate binding protein 2, interferon-inducible
GJA8 gap junction protein, alpha 8, 50kDa
GLS2 glutaminase 2 (liver, mitochondrial)
GPR87 G protein-coupled receptor 87
GSTCD glutathione S-transferase, C-terminal domain containing
GSTP1 glutathione S-transferase pi 1
GTF2I general transcription factor IIi
HDAC7 histone deacetylase 7
HEXA-AS1 HEXA antisense RNA 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H2BM histone cluster 1, H2bm
HIST1H3B histone cluster 1, H3b
HOXA3 homeobox A3
HOXC6 homeobox C6
IL4R interleukin 4 receptor
INO80D INO80 complex subunit D
ITPKB inositol-trisphosphate 3-kinase B
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF13 Kruppel-like factor 13
KLF7 Kruppel-like factor 7 (ubiquitous)
KRT15 keratin 15, type I
LENEP lens epithelial protein
LIG4 ligase IV, DNA, ATP-dependent
LIN7A lin-7 homolog A (C. elegans)
LONRF3 LON peptidase N-terminal domain and ring finger 3
LRP2 low density lipoprotein receptor-related protein 2
MAK male germ cell-associated kinase
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MEGF8 multiple EGF-like-domains 8
MFSD6 major facilitator superfamily domain containing 6
MGC2889 uncharacterized protein MGC2889
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NOD1 nucleotide-binding oligomerization domain containing 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NRDE2 NRDE-2, necessary for RNA interference, domain containing
NSUN6 NOP2/Sun domain family, member 6
ONECUT2 one cut homeobox 2
PAIP2B poly(A) binding protein interacting protein 2B
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PCDHA5 protocadherin alpha 5
PCDHA9 protocadherin alpha 9
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLCD1 phospholipase C, delta 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTPN14 protein tyrosine phosphatase, non-receptor type 14
QSER1 glutamine and serine rich 1
RASIP1 Ras interacting protein 1
RLN1 relaxin 1
RNF122 ring finger protein 122
SLC22A14 solute carrier family 22, member 14
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
STXBP5L syntaxin binding protein 5-like
SYNPO synaptopodin
TBC1D2 TBC1 domain family, member 2
TESC tescalcin
TMEM121 transmembrane protein 121
TMEM45A transmembrane protein 45A
TMPRSS4 transmembrane protease, serine 4
TUBB1 tubulin, beta 1 class VI
UCN urocortin
UNC119 unc-119 homolog (C. elegans)
VAX2 ventral anterior homeobox 2
VEGFC vascular endothelial growth factor C
WWC2 WW and C2 domain containing 2
ZNF358 zinc finger protein 358
ZNF492 zinc finger protein 492
ZNF76 zinc finger protein 76