securinine-4493 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the securinine-4493 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ABHD3 abhydrolase domain containing 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
APOE apolipoprotein E
AREG amphiregulin
ATF7IP2 activating transcription factor 7 interacting protein 2
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFH complement factor H
CIC capicua transcriptional repressor
CLCF1 cardiotrophin-like cytokine factor 1
CRHR2 corticotropin releasing hormone receptor 2
CSF1 colony stimulating factor 1 (macrophage)
CTIF CBP80/20-dependent translation initiation factor
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DGCR2 DiGeorge syndrome critical region gene 2
DHRS9 dehydrogenase/reductase (SDR family) member 9
DIO2 deiodinase, iodothyronine, type II
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DSTYK dual serine/threonine and tyrosine protein kinase
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
ECE1 endothelin converting enzyme 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ESRRG estrogen-related receptor gamma
EXOSC2 exosome component 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FAT2 FAT atypical cadherin 2
FOSL2 FOS-like antigen 2
FST follistatin
GABARAPL1 GABA(A) receptor-associated protein like 1
GAN gigaxonin
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HOXD1 homeobox D1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IL12A interleukin 12A
IL6R interleukin 6 receptor
JMJD6 jumonji domain containing 6
JUND jun D proto-oncogene
KIAA0232 KIAA0232
KLHL21 kelch-like family member 21
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOC399491
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MIR22HG MIR22 host gene
NQO1 NAD(P)H dehydrogenase, quinone 1
OSGIN1 oxidative stress induced growth inhibitor 1
OXCT2 3-oxoacid CoA transferase 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLK3 polo-like kinase 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
RASAL2 RAS protein activator like 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIT1 Ras-like without CAAX 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RUNX1 runt-related transcription factor 1
SEC24A SEC24 family member A
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SP4 Sp4 transcription factor
SQSTM1 sequestosome 1
SRF serum response factor (c-fos serum response element-binding transcription factor)
TAOK2 TAO kinase 2
TAS2R10 taste receptor, type 2, member 10
TBXA2R thromboxane A2 receptor
TGFB2 transforming growth factor, beta 2
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRIM16 tripartite motif containing 16
TTC38 tetratricopeptide repeat domain 38
TXNRD1 thioredoxin reductase 1
UGCG UDP-glucose ceramide glucosyltransferase
UGDH UDP-glucose 6-dehydrogenase
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZFP36 ZFP36 ring finger protein
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANKRD36B ankyrin repeat domain 36B
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
C14ORF93 chromosome 14 open reading frame 93
C1RL complement component 1, r subcomponent-like
C4ORF29 chromosome 4 open reading frame 29
C5ORF45 chromosome 5 open reading frame 45
CAPN5 calpain 5
CBR4 carbonyl reductase 4
CBX7 chromobox homolog 7
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC106 coiled-coil domain containing 106
CFAP69 cilia and flagella associated protein 69
CIDEC cell death-inducing DFFA-like effector c
CTGF connective tissue growth factor
CTSF cathepsin F
CUL9 cullin 9
DEPTOR DEP domain containing MTOR-interacting protein
DTX4 deltex 4, E3 ubiquitin ligase
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM50B family with sequence similarity 50, member B
FZD4 frizzled class receptor 4
GAMT guanidinoacetate N-methyltransferase
GLS2 glutaminase 2 (liver, mitochondrial)
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GUSBP3 glucuronidase, beta pseudogene 3
H1F0 H1 histone family, member 0
HIST1H2AI histone cluster 1, H2ai
HOXA10 homeobox A10
HOXA4 homeobox A4
HOXA5 homeobox A5
HOXB13 homeobox B13
HOXB9 homeobox B9
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL17RB interleukin 17 receptor B
IL33 interleukin 33
IL7 interleukin 7
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
LOC730101 uncharacterized LOC730101
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LY6G5C lymphocyte antigen 6 complex, locus G5C
LY86 lymphocyte antigen 86
LYPD3 LY6/PLAUR domain containing 3
MANBA mannosidase, beta A, lysosomal
MCC mutated in colorectal cancers
MCMBP minichromosome maintenance complex binding protein
MOB3B MOB kinase activator 3B
MX1 MX dynamin-like GTPase 1
NAT6 N-acetyltransferase 6 (GCN5-related)
NDP Norrie disease (pseudoglioma)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NINJ1 ninjurin 1
NREP neuronal regeneration related protein
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
OVGP1 oviductal glycoprotein 1, 120kDa
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PALMD palmdelphin
PAX6 paired box 6
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
POLL polymerase (DNA directed), lambda
POLM polymerase (DNA directed), mu
POMT2 protein-O-mannosyltransferase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRR15L proline rich 15-like
PTPRE protein tyrosine phosphatase, receptor type, E
PTX3 pentraxin 3, long
RANBP6 RAN binding protein 6
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
SCEL sciellin
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SHROOM2 shroom family member 2
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLITRK5 SLIT and NTRK-like family, member 5
SNPH syntaphilin
SPATA7 spermatogenesis associated 7
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SYT17 synaptotagmin XVII
TENM4 teneurin transmembrane protein 4
THBS3 thrombospondin 3
TMEM121 transmembrane protein 121
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNS2 tensin 2
TRAF5 TNF receptor-associated factor 5
TRIM25 tripartite motif containing 25
TRIM52 tripartite motif containing 52
TRIM9 tripartite motif containing 9
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UNC119 unc-119 homolog (C. elegans)
WDR76 WD repeat domain 76
ZBED8 zinc finger, BED-type containing 8
ZNF204P zinc finger protein 204, pseudogene
ZNF205 zinc finger protein 205
ZNF365 zinc finger protein 365
ZNF442 zinc finger protein 442