secretory granule Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. (Gene Ontology, GO_0030141)
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Genes

275 proteins localized to the secretory granule cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
ANXA3 annexin A3 0.663342
SNAP23 synaptosomal-associated protein, 23kDa 0.663342
SLC30A5 solute carrier family 30 (zinc transporter), member 5 0.663342
CPA3 carboxypeptidase A3 (mast cell) 0.663342
CRISP3 cysteine-rich secretory protein 3 0.663342
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.663342
RAB10 RAB10, member RAS oncogene family 0.663342
RAB14 RAB14, member RAS oncogene family 0.663342
SPINK5 serine peptidase inhibitor, Kazal type 5 0.663342
LACRT lacritin 0.663342
KLK7 kallikrein-related peptidase 7 0.663342
KLK5 kallikrein-related peptidase 5 0.663342
RACGAP1 Rac GTPase activating protein 1 0.663342
NAPSA napsin A aspartic peptidase 0.663342
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.663342
ICA1 islet cell autoantigen 1, 69kDa 0.663342
CARTPT CART prepropeptide 0.663342
CASC5 cancer susceptibility candidate 5 0.663342
ACRV1 acrosomal vesicle protein 1 0.663342
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.663342
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.663342
LAMP2 lysosomal-associated membrane protein 2 0.663342
VEGFA vascular endothelial growth factor A 0.663342
AZU1 azurocidin 1 0.663342
SPAG9 sperm associated antigen 9 0.663342
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 0.663342
SPACA7 sperm acrosome associated 7 0.663342
SPACA3 sperm acrosome associated 3 0.663342
ELANE elastase, neutrophil expressed 0.663342
MPO myeloperoxidase 0.663342
TREML1 triggering receptor expressed on myeloid cells-like 1 0.663342
STX3 syntaxin 3 0.663342
STX4 syntaxin 4 0.663342
BRCA2 breast cancer 2, early onset 0.663342
VWF von Willebrand factor 0.663342
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.663342
STXBP1 syntaxin binding protein 1 0.663342
HPS4 Hermansky-Pudlak syndrome 4 0.663342
ANXA11 annexin A11 0.663342
LTF lactotransferrin 0.663342
VPS33B vacuolar protein sorting 33 homolog B (yeast) 0.663342
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 0.663342
STXBP3 syntaxin binding protein 3 0.663342
STXBP2 syntaxin binding protein 2 0.663342
CRHBP corticotropin releasing hormone binding protein 0.663342
CTSH cathepsin H 0.663342
SYT1 synaptotagmin I 0.663342
CTSG cathepsin G 0.663342
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 0.663342
THBS2 thrombospondin 2 0.663342
FN1 fibronectin 1 0.237908
ADAM8 ADAM metallopeptidase domain 8 0.237908
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 0.237908
F8 coagulation factor VIII, procoagulant component 0.237908
CD63 CD63 molecule 0.237908
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.237908
F5 coagulation factor V (proaccelerin, labile factor) 0.237908
RAB26 RAB26, member RAS oncogene family 0.237908
LEFTY2 left-right determination factor 2 0.237908
TOR1A torsin family 1, member A (torsin A) 0.237908
THBS1 thrombospondin 1 0.237908
DENND4C DENN/MADD domain containing 4C 0.237908
GCG glucagon 0.237908
APOA1 apolipoprotein A-I 0.237908
ALDOA aldolase A, fructose-bisphosphate 0.237908
MYRIP myosin VIIA and Rab interacting protein 0.237908
PLG plasminogen 0.237908
MMRN1 multimerin 1 0.237908
CD36 CD36 molecule (thrombospondin receptor) 0.237908
MYO5A myosin VA (heavy chain 12, myoxin) 0.237908
HRG histidine-rich glycoprotein 0.237908
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.237908
VEGFC vascular endothelial growth factor C 0.237908
SRGN serglycin 0.237908
EXOC3 exocyst complex component 3 0.237908
SNAPIN SNAP-associated protein 0.237908
VEGFB vascular endothelial growth factor B 0.237908
INS insulin 0.237908
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.237908
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.237908
CLU clusterin 0.237908
KNG1 kininogen 1 0.237908
SCG5 secretogranin V 0.237908
GAS6 growth arrest-specific 6 0.237908
RAB11FIP5 RAB11 family interacting protein 5 (class I) 0.237908
SCG3 secretogranin III 0.237908
GIP gastric inhibitory polypeptide 0.237908
FIGF c-fos induced growth factor (vascular endothelial growth factor D) 0.237908
EQTN equatorin, sperm acrosome associated 0.237908
POMC proopiomelanocortin 0.237908
ALB albumin 0.237908
CD9 CD9 molecule 0.237908
ACR acrosin 0.237908
RAB13 RAB13, member RAS oncogene family 0.237908
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.237908
CA4 carbonic anhydrase IV 0.237908
TGFB1 transforming growth factor, beta 1 0.237908
TGFB2 transforming growth factor, beta 2 0.237908
TGFB3 transforming growth factor, beta 3 0.237908
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.237908
VAMP8 vesicle-associated membrane protein 8 0.237908
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.237908
SLC30A8 solute carrier family 30 (zinc transporter), member 8 0.237908
EXOC3L1 exocyst complex component 3-like 1 0.237908
EGF epidermal growth factor 0.237908
OLFM4 olfactomedin 4 0.237908
GHRL ghrelin/obestatin prepropeptide 0.237908
A2M alpha-2-macroglobulin 0.237908
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.237908
GHRHR growth hormone releasing hormone receptor 0.237908
RAB4B RAB4B, member RAS oncogene family 0.237908
APP amyloid beta (A4) precursor protein 0.237908
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 0.237908
ASTL astacin-like metallo-endopeptidase (M12 family) 0.237908
CYBA cytochrome b-245, alpha polypeptide 0.237908
DEFA1B defensin, alpha 1B 0.237908
CPE carboxypeptidase E 0.237908
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 0.237908
TMSB4X thymosin beta 4, X-linked 0.237908
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 0.237908
PF4 platelet factor 4 0.237908
ECE1 endothelin converting enzyme 1 0.237908
ACTN4 actinin, alpha 4 0.237908
PCSK2 proprotein convertase subtilisin/kexin type 2 0.237908
PCSK1 proprotein convertase subtilisin/kexin type 1 0.237908
ACTN1 actinin, alpha 1 0.237908
ACTN2 actinin, alpha 2 0.237908
HILPDA hypoxia inducible lipid droplet-associated 0.237908
TIMP1 TIMP metallopeptidase inhibitor 1 0.237908
CUZD1 CUB and zona pellucida-like domains 1 0.237908
DMBT1 deleted in malignant brain tumors 1 0.237908
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.237908
FGG fibrinogen gamma chain 0.237908
FGA fibrinogen alpha chain 0.237908
PDGFA platelet-derived growth factor alpha polypeptide 0.237908
PDGFB platelet-derived growth factor beta polypeptide 0.237908
FGB fibrinogen beta chain 0.237908
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.237908
CFD complement factor D (adipsin) 0.237908
IGF2 insulin-like growth factor 2 0.237908
IGF1 insulin-like growth factor 1 (somatomedin C) 0.237908
PROS1 protein S (alpha) 0.237908
F13A1 coagulation factor XIII, A1 polypeptide 0.237908
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 0.237908
DEFA5 defensin, alpha 5, Paneth cell-specific 0.237908
CXADR coxsackie virus and adenovirus receptor 0.237908
TF transferrin 0.237908
DEFA1 defensin, alpha 1 0.237908
DEFA3 defensin, alpha 3, neutrophil-specific 0.237908
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.098109
TMED2 transmembrane emp24 domain trafficking protein 2 0.098109
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.098109
TEKT3 tektin 3 0.098109
PCSK5 proprotein convertase subtilisin/kexin type 5 0.098109
FABP9 fatty acid binding protein 9, testis 0.03318
IZUMO1 izumo sperm-egg fusion 1 0.03318
TFF3 trefoil factor 3 (intestinal) 0.03318
SYT9 synaptotagmin IX 0.03318
SYT4 synaptotagmin IV 0.03318
CAPN11 calpain 11 0.03318
GCK glucokinase (hexokinase 4) 0.03318
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.03318
SYT5 synaptotagmin V 0.03318
TMEM190 transmembrane protein 190 0.03318
RAB3B RAB3B, member RAS oncogene family 0.03318
IFT88 intraflagellar transport 88 0.03318
AKAP3 A kinase (PRKA) anchor protein 3 0.03318
OXT oxytocin/neurophysin I prepropeptide 0.03318
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.03318
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.03318
USP8 ubiquitin specific peptidase 8 0.03318
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.03318
ZG16 zymogen granule protein 16 0.03318
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.03318
ZPBP zona pellucida binding protein 0.03318
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.03318
STX1A syntaxin 1A (brain) 0.03318
IQUB IQ motif and ubiquitin domain containing 0.03318
TEX101 testis expressed 101 0.03318
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.03318
RPH3AL rabphilin 3A-like (without C2 domains) 0.03318
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.03318
CRCP CGRP receptor component 0.03318
SCAMP1 secretory carrier membrane protein 1 0.03318
PCSK4 proprotein convertase subtilisin/kexin type 4 0.03318
GKN1 gastrokine 1 0.03318
ATP7A ATPase, Cu++ transporting, alpha polypeptide 0.03318
GLIPR1L1 GLI pathogenesis-related 1 like 1 0.03318
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.03318
TRIP11 thyroid hormone receptor interactor 11 0.03318
POMT1 protein-O-mannosyltransferase 1 0.03318
SYT7 synaptotagmin VII 0.03318
RAB37 RAB37, member RAS oncogene family 0.03318
PAM peptidylglycine alpha-amidating monooxygenase 0.03318
CD46 CD46 molecule, complement regulatory protein 0.03318
RAB3D RAB3D, member RAS oncogene family 0.03318
SKIL SKI-like proto-oncogene 0.03318
RAB27B RAB27B, member RAS oncogene family 0.03318
CATSPER4 cation channel, sperm associated 4 0.03318
CATSPER3 cation channel, sperm associated 3 0.03318
ACPP acid phosphatase, prostate 0.03318
RAB27A RAB27A, member RAS oncogene family 0.03318
CALR calreticulin 0.03318
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 0.03318
SCG2 secretogranin II 0.03318
RAB7A RAB7A, member RAS oncogene family 0.03318
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 0.03318
CAV1 caveolin 1, caveolae protein, 22kDa 0.03318
CAV2 caveolin 2 0.03318
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 0.03318
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 0.03318
TSSK2 testis-specific serine kinase 2 0.03318
SEMG2 semenogelin II 0.03318
ZPBP2 zona pellucida binding protein 2 0.03318
SEMG1 semenogelin I 0.03318
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.03318
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.03318
BSG basigin (Ok blood group) 0.03318
SFTPC surfactant protein C 0.03318
SYPL1 synaptophysin-like 1 0.03318
ARSA arylsulfatase A 0.03318
AVP arginine vasopressin 0.03318
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 0.03318
STK31 serine/threonine kinase 31 0.03318
ANGPTL6 angiopoietin-like 6 0.03318
CAPZB capping protein (actin filament) muscle Z-line, beta 0.03318
SYTL4 synaptotagmin-like 4 0.03318
LAMP1 lysosomal-associated membrane protein 1 0.03318
LAMP3 lysosomal-associated membrane protein 3 0.03318
CLCA1 chloride channel accessory 1 0.03318
FSTL3 follistatin-like 3 (secreted glycoprotein) 0.03318
FLOT2 flotillin 2 0.03318
SUN1 Sad1 and UNC84 domain containing 1 0.03318
TBC1D21 TBC1 domain family, member 21 0.03318
TCTEX1D4 Tctex1 domain containing 4 0.03318
FNDC3A fibronectin type III domain containing 3A 0.03318
SYCN syncollin 0.03318
SPACA1 sperm acrosome associated 1 0.03318
PLA2G1B phospholipase A2, group IB (pancreas) 0.03318
HEXB hexosaminidase B (beta polypeptide) 0.03318
PLAT plasminogen activator, tissue 0.03318
DRD2 dopamine receptor D2 0.03318
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.03318
IL1B interleukin 1, beta 0.03318
RAB12 RAB12, member RAS oncogene family 0.03318
CAPZA3 capping protein (actin filament) muscle Z-line, alpha 3 0.03318
GAL galanin/GMAP prepropeptide 0.03318
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 0.03318
CAMP cathelicidin antimicrobial peptide 0.03318
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 0.03318
PATE4 prostate and testis expressed 4 0.03318
KLK13 kallikrein-related peptidase 13 0.03318
TRIM36 tripartite motif containing 36 0.03318
SNORA29 small nucleolar RNA, H/ACA box 29 0.03318
NPPC natriuretic peptide C 0.03318
TRH thyrotropin-releasing hormone 0.03318
NCF2 neutrophil cytosolic factor 2 0.03318
SPESP1 sperm equatorial segment protein 1 0.03318
SLIRP SRA stem-loop interacting RNA binding protein 0.03318
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.03318
HCRT hypocretin (orexin) neuropeptide precursor 0.03318
VAMP3 vesicle-associated membrane protein 3 0.03318
RESP18 regulated endocrine-specific protein 18 0.03318
ITGA1 integrin, alpha 1 0.03318
GARS glycyl-tRNA synthetase 0.03318
ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 0.03318
RAB3A RAB3A, member RAS oncogene family 0.03318
CHGA chromogranin A 0.03318
CHGB chromogranin B 0.03318
CDC42 cell division cycle 42 0.03318
PRL prolactin 0.03318
DLD dihydrolipoamide dehydrogenase 0.03318
TBXA2R thromboxane A2 receptor 0.03318
EBAG9 estrogen receptor binding site associated, antigen, 9 0.03318
BMF Bcl2 modifying factor 0.03318