secondary hypertension Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

194 genes co-occuring with the disease secondary hypertension in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
REN renin 3.38408
ACE angiotensin I converting enzyme 2.29202
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 1.53701
NPPA natriuretic peptide A 1.41753
ADRB1 adrenoceptor beta 1 1.28872
KNG1 kininogen 1 1.27475
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.2382
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 1.15837
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.03535
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.02903
ALB albumin 1.02819
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 1.01638
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.933313
SLC22A10 solute carrier family 22, member 10 0.919261
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 0.905675
DNAH8 dynein, axonemal, heavy chain 8 0.84544
TGFB1 transforming growth factor, beta 1 0.845031
AGTR1 angiotensin II receptor, type 1 0.828229
MYH9 myosin, heavy chain 9, non-muscle 0.823718
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.821667
APOL1 apolipoprotein L, 1 0.774932
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 0.770027
PNMT phenylethanolamine N-methyltransferase 0.768801
FBXL20 F-box and leucine-rich repeat protein 20 0.766351
FN1 fibronectin 1 0.750457
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.739488
MPV17 MpV17 mitochondrial inner membrane protein 0.733406
CLIP1 CAP-GLY domain containing linker protein 1 0.6939
NOS3 nitric oxide synthase 3 (endothelial cell) 0.692296
NF1 neurofibromin 1 0.688692
EDN1 endothelin 1 0.687491
AVP arginine vasopressin 0.687091
EDNRA endothelin receptor type A 0.65565
POMC proopiomelanocortin 0.648138
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 0.644981
ADM adrenomedullin 0.633169
LYZ lysozyme 0.62885
SOD2 superoxide dismutase 2, mitochondrial 0.60147
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.59913
DCLRE1C DNA cross-link repair 1C 0.57305
CD79A CD79a molecule, immunoglobulin-associated alpha 0.57305
RND3 Rho family GTPase 3 0.557509
C5ORF38 chromosome 5 open reading frame 38 0.554403
CABIN1 calcineurin binding protein 1 0.533861
APLNR apelin receptor 0.493503
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 0.487027
RAMP3 receptor (G protein-coupled) activity modifying protein 3 0.469197
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.468063
KCNK9 potassium channel, two pore domain subfamily K, member 9 0.453339
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.452962
KPNA3 karyopherin alpha 3 (importin alpha 4) 0.416521
SGK1 serum/glucocorticoid regulated kinase 1 0.406051
CHGA chromogranin A 0.396725
SMTN smoothelin 0.394118
HMOX1 heme oxygenase 1 0.393746
EPHX2 epoxide hydrolase 2, cytoplasmic 0.381852
TH tyrosine hydroxylase 0.373328
MUC20 mucin 20, cell surface associated 0.369997
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 0.369258
INS insulin 0.357446
PEX3 peroxisomal biogenesis factor 3 0.354868
DUOX1 dual oxidase 1 0.347879
SCNN1B sodium channel, non voltage gated 1 beta subunit 0.346409
NOX4 NADPH oxidase 4 0.345308
MYOZ2 myozenin 2 0.341272
DNPEP aspartyl aminopeptidase 0.331025
DUOX2 dual oxidase 2 0.328105
SPP1 secreted phosphoprotein 1 0.325916
GRK4 G protein-coupled receptor kinase 4 0.322273
ACE2 angiotensin I converting enzyme 2 0.320454
A1CF APOBEC1 complementation factor 0.32009
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.319726
MMP2 matrix metallopeptidase 2 0.317545
B2M beta-2-microglobulin 0.31464
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.31029
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 0.309204
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.298731
CARTPT CART prepropeptide 0.294413
MOBP myelin-associated oligodendrocyte basic protein 0.291539
PDGFA platelet-derived growth factor alpha polypeptide 0.291539
ACRBP acrosin binding protein 0.290462
MLPH melanophilin 0.284013
GPS1 G protein pathway suppressor 1 0.281153
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.280796
MADD MAP-kinase activating death domain 0.279011
CALCRL calcitonin receptor-like 0.275445
ADCY2 adenylate cyclase 2 (brain) 0.273664
KLK15 kallikrein-related peptidase 15 0.273308
TPSG1 tryptase gamma 1 0.269043
BEST3 bestrophin 3 0.264431
CAT catalase 0.261952
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.251015
NTSR1 neurotensin receptor 1 (high affinity) 0.249257
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 0.241196
SYNPO synaptopodin 0.23945
RHOB ras homolog family member B 0.239101
COL8A1 collagen, type VIII, alpha 1 0.23492
SCNN1G sodium channel, non voltage gated 1 gamma subunit 0.231448
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.228679
CALCA calcitonin-related polypeptide alpha 0.222136
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 0.221793
NPY neuropeptide Y 0.217693
TDGF1 teratocarcinoma-derived growth factor 1 0.213621
WNK4 WNK lysine deficient protein kinase 4 0.209583
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 0.208579
MLX MLX, MAX dimerization protein 0.207912
FOS FBJ murine osteosarcoma viral oncogene homolog 0.204263
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.201635
GHR growth hormone receptor 0.201308
RNPEP arginyl aminopeptidase (aminopeptidase B) 0.196779
PTH parathyroid hormone 0.196459
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.196459
IL4I1 interleukin 4 induced 1 0.193285
CTGF connective tissue growth factor 0.187113
PTPRO protein tyrosine phosphatase, receptor type, O 0.18621
NPR1 natriuretic peptide receptor 1 0.18591
GUCY2C guanylate cyclase 2C 0.185016
GJA5 gap junction protein, alpha 5, 40kDa 0.179239
KL klotho 0.179239
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.171286
TRPM3 transient receptor potential cation channel, subfamily M, member 3 0.171036
CMA1 chymase 1, mast cell 0.169571
NAGS N-acetylglutamate synthase 0.168617
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 0.167915
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.167682
AMT aminomethyltransferase 0.163317
ERAS ES cell expressed Ras 0.162908
BMP5 bone morphogenetic protein 5 0.162306
EDA ectodysplasin A 0.160021
STK39 serine threonine kinase 39 0.158951
HBD hemoglobin, delta 0.140394
HBB hemoglobin, beta 0.139115
THOP1 thimet oligopeptidase 1 0.137563
CTSA cathepsin A 0.137026
CCL2 chemokine (C-C motif) ligand 2 0.135819
ADIPOQ adiponectin, C1Q and collagen domain containing 0.131519
COL8A2 collagen, type VIII, alpha 2 0.130709
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.130693
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 0.130037
SMOX spermine oxidase 0.129746
MIR192 microRNA 192 0.128351
SDCBP syndecan binding protein (syntenin) 0.127755
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 0.12698
KRT3 keratin 3, type II 0.126894
SZRD1 SUZ RNA binding domain containing 1 0.125576
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.125457
PDGFB platelet-derived growth factor beta polypeptide 0.125118
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.124995
JAG1 jagged 1 0.12462
DCN decorin 0.123818
PAOX polyamine oxidase (exo-N4-amino) 0.123029
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 0.12272
FGB fibrinogen beta chain 0.122435
SDHAF2 succinate dehydrogenase complex assembly factor 2 0.12229
PAX4 paired box 4 0.121032
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.120627
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 0.120306
PPT2 palmitoyl-protein thioesterase 2 0.120082
CR2 complement component (3d/Epstein Barr virus) receptor 2 0.119753
TSN translin 0.119554
S100G S100 calcium binding protein G 0.119323
DDAH2 dimethylarginine dimethylaminohydrolase 2 0.118912
GCDH glutaryl-CoA dehydrogenase 0.118707
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 0.118392
LAT linker for activation of T cells 0.11818
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 0.11811
SUMF1 sulfatase modifying factor 1 0.117753
ANPEP alanyl (membrane) aminopeptidase 0.117021
SACS sacsin molecular chaperone 0.116493
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase 0.116381
TGFB2 transforming growth factor, beta 2 0.116149
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 0.115955
DCPS decapping enzyme, scavenger 0.115838
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 0.1158
EGR1 early growth response 1 0.115605
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.114646
RAMP2 receptor (G protein-coupled) activity modifying protein 2 0.113649
MME membrane metallo-endopeptidase 0.113095
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 0.112881
MLXIPL MLX interacting protein-like 0.111913
MPO myeloperoxidase 0.111551
MUL1 mitochondrial E3 ubiquitin protein ligase 1 0.111506
PCNA proliferating cell nuclear antigen 0.111506
ACTN4 actinin, alpha 4 0.11119
YME1L1 YME1-like 1 ATPase 0.111054
NPR3 natriuretic peptide receptor 3 0.110961
NID1 nidogen 1 0.110961
YBX1 Y box binding protein 1 0.110635
PGF placental growth factor 0.110635
MATN1 matrilin 1, cartilage matrix protein 0.110635
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.110635
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.110542
CPN1 carboxypeptidase N, polypeptide 1 0.10955
CPA6 carboxypeptidase A6 0.109502