schizoaffective disorder Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A psychotic disorder that is characterized by recurring episodes of mood fluctuations and a loss of contact with reality. (Human Disease Ontology, DOID_5418)
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Genes

174 genes co-occuring with the disease schizoaffective disorder in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) 1.64218
DTNBP1 dystrobrevin binding protein 1 1.51501
DISC1 disrupted in schizophrenia 1 1.43069
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 1.36945
DRD2 dopamine receptor D2 1.29352
TAAR6 trace amine associated receptor 6 1.29047
DAOA D-amino acid oxidase activator 1.27257
PRODH proline dehydrogenase (oxidase) 1 1.26647
SDSL serine dehydratase-like 1.24776
C16ORF72 chromosome 16 open reading frame 72 1.21175
POM121L7 POM121 transmembrane nucleoporin-like 7 1.20742
SULT4A1 sulfotransferase family 4A, member 1 1.20223
DRD4 dopamine receptor D4 1.19877
SRCIN1 SRC kinase signaling inhibitor 1 1.1798
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 1.17765
DGCR6 DiGeorge syndrome critical region gene 6 1.17464
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.16649
MYO16 myosin XVI 1.1605
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.15538
COMT catechol-O-methyltransferase 1.15283
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 1.14942
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 1.13882
PNP purine nucleoside phosphorylase 1.10804
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 1.06984
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.0585
MIOS missing oocyte, meiosis regulator, homolog (Drosophila) 1.0585
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 1.05135
DGCR14 DiGeorge syndrome critical region gene 14 1.04504
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.995283
DRD3 dopamine receptor D3 0.988957
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.986007
BDNF brain-derived neurotrophic factor 0.974221
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.97254
TUBA8 tubulin, alpha 8 0.954108
ACSL6 acyl-CoA synthetase long-chain family member 6 0.946603
GRID1 glutamate receptor, ionotropic, delta 1 0.933313
STX7 syntaxin 7 0.926279
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 0.922149
DGKH diacylglycerol kinase, eta 0.911433
DEFB1 defensin, beta 1 0.887208
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.873691
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 0.872053
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.864274
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 0.863046
C19ORF33 chromosome 19 open reading frame 33 0.845031
NRG1 neuregulin 1 0.839296
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.836017
RORB RAR-related orphan receptor B 0.831099
IL2RB interleukin 2 receptor, beta 0.829869
GRM3 glutamate receptor, metabotropic 3 0.824128
DEFA4 defensin, alpha 4, corticostatin 0.823308
ZNF804A zinc finger protein 804A 0.815924
LRRTM1 leucine rich repeat transmembrane neuronal 1 0.803616
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.794591
DRD5 dopamine receptor D5 0.786394
MIR137 microRNA 137 0.756564
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 0.745578
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.743141
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.715215
RGS4 regulator of G-protein signaling 4 0.698313
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.690694
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 0.680297
PER3 period circadian clock 3 0.678302
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.664372
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 0.66199
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.658422
FGA fibrinogen alpha chain 0.652089
MARCKS myristoylated alanine-rich protein kinase C substrate 0.648533
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.640251
BDH1 3-hydroxybutyrate dehydrogenase, type 1 0.636315
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.625319
PXT1 peroxisomal, testis specific 1 0.624927
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 0.606152
VIPR2 vasoactive intestinal peptide receptor 2 0.59913
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 0.598351
ACSL4 acyl-CoA synthetase long-chain family member 4 0.596402
PER1 period circadian clock 1 0.591337
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 0.587054
AUTS2 autism susceptibility candidate 2 0.568775
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.567609
INS insulin 0.561004
CALR calreticulin 0.543542
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 0.542379
KCNK6 potassium channel, two pore domain subfamily K, member 6 0.541605
CARS cysteinyl-tRNA synthetase 0.540055
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.53928
TRH thyrotropin-releasing hormone 0.533088
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) 0.521888
MEF2D myocyte enhancer factor 2D 0.521502
BPI bactericidal/permeability-increasing protein 0.514571
NPAS2 neuronal PAS domain protein 2 0.514571
TIMELESS timeless circadian clock 0.50689
VRK1 vaccinia related kinase 1 0.503441
PTPRG protein tyrosine phosphatase, receptor type, G 0.495029
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.494648
DMRTA1 DMRT-like family A1 0.491215
CHRM1 cholinergic receptor, muscarinic 1 0.486266
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.485125
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.484364
RELN reelin 0.482464
GFRA1 GDNF family receptor alpha 1 0.480186
INSIG2 insulin induced gene 2 0.474877
IL18RAP interleukin 18 receptor accessory protein 0.474877
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.471846
GRIK4 glutamate receptor, ionotropic, kainate 4 0.468819
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.465416
BSN bassoon presynaptic cytomatrix protein 0.449571
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 0.445805
MIR107 microRNA 107 0.445052
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 0.440914
IL18R1 interleukin 18 receptor 1 0.440914
ADRA1A adrenoceptor alpha 1A 0.431519
PRKCA protein kinase C, alpha 0.418768
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 0.416896
TBX1 T-box 1 0.416896
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 0.409787
GRM4 glutamate receptor, metabotropic 4 0.407919
TPH1 tryptophan hydroxylase 1 0.400453
IL10RA interleukin 10 receptor, alpha 0.392257
NEUROG1 neurogenin 1 0.388166
CLNK cytokine-dependent hematopoietic cell linker 0.387794
AOX1 aldehyde oxidase 1 0.385193
NADK NAD kinase 0.38111
SAT1 spermidine/spermine N1-acetyltransferase 1 0.377773
PRL prolactin 0.371477
EGR3 early growth response 3 0.369258
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.36741
DPYSL2 dihydropyrimidinase-like 2 0.364085
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 0.342739
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.334681
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.332852
DRD1 dopamine receptor D1 0.32993
PDZK1IP1 PDZK1 interacting protein 1 0.328105
IL18BP interleukin 18 binding protein 0.32701
TBK1 TANK-binding kinase 1 0.32009
MAOA monoamine oxidase A 0.319726
ADRA2A adrenoceptor alpha 2A 0.319363
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.315366
SIRT5 sirtuin 5 0.315003
EVL Enah/Vasp-like 0.313552
DAO D-amino-acid oxidase 0.308842
NRXN1 neurexin 1 0.306672
PIDD1 p53-induced death domain protein 1 0.305226
FGD1 FYVE, RhoGEF and PH domain containing 1 0.30342
JMJD6 jumonji domain containing 6 0.300894
GZMM granzyme M (lymphocyte met-ase 1) 0.295851
KDM1A lysine (K)-specific demethylase 1A 0.295132
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.291898
PTER phosphotriesterase related 0.290462
SNAP23 synaptosomal-associated protein, 23kDa 0.28831
PER2 period circadian clock 2 0.275801
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.274376
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 0.272597
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.268687
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.24996
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.249608
SIX1 SIX homeobox 1 0.242595
MLXIPL MLX interacting protein-like 0.240497
CNOT2 CCR4-NOT transcription complex, subunit 2 0.239799
NTS neurotensin 0.22937
NOTCH4 notch 4 0.221108
APOA5 apolipoprotein A-V 0.212945
CAPN10 calpain 10 0.211261
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.210925
HMOX2 heme oxygenase 2 0.20658
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.20229
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.189244
S100A12 S100 calcium binding protein A12 0.187113
ADCY2 adenylate cyclase 2 (brain) 0.175679
SST somatostatin 0.171785
CRX cone-rod homeobox 0.167682
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.162707
MFGE8 milk fat globule-EGF factor 8 protein 0.158778
BCHE butyrylcholinesterase 0.157929