scf ubiquitin ligase complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). (Gene Ontology, GO_0019005)
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127 proteins co-occuring with the scf ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SKP1 S-phase kinase-associated protein 1 2.81429
CUL1 cullin 1 2.67089
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 2.08599
RBX1 ring-box 1, E3 ubiquitin protein ligase 1.83406
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 1.78979
CAND1 cullin-associated and neddylation-dissociated 1 1.50735
CDC34 cell division cycle 34 1.33142
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 1.28943
FBXO27 F-box protein 27 1.27399
UBE2H ubiquitin-conjugating enzyme E2H 1.21842
FBXW2 F-box and WD repeat domain containing 2 1.15928
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 1.13318
FBXO2 F-box protein 2 1.10715
PARK2 parkin RBR E3 ubiquitin protein ligase 1.08222
UBE2S ubiquitin-conjugating enzyme E2S 1.05337
FBXL2 F-box and leucine-rich repeat protein 2 1.04984
UBE2M ubiquitin-conjugating enzyme E2M 1.03428
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.01684
FBXL12 F-box and leucine-rich repeat protein 12 1.01387
RNF31 ring finger protein 31 1.00942
FBXL16 F-box and leucine-rich repeat protein 16 0.98927
FBXW5 F-box and WD repeat domain containing 5 0.976135
FBXO18 F-box protein, helicase, 18 0.95831
FBXW9 F-box and WD repeat domain containing 9 0.917644
ZC3HC1 zinc finger, C3HC-type containing 1 0.917177
FBXO6 F-box protein 6 0.905996
CDCA3 cell division cycle associated 3 0.899036
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) 0.86123
FLI1 Fli-1 proto-oncogene, ETS transcription factor 0.856635
FBXO11 F-box protein 11 0.815781
CDC25A cell division cycle 25A 0.788275
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 0.766349
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.756799
COPS5 COP9 signalosome subunit 5 0.75181
FBXO45 F-box protein 45 0.735115
FBXO25 F-box protein 25 0.726599
CUL7 cullin 7 0.719906
NUB1 negative regulator of ubiquitin-like proteins 1 0.709693
RTN4RL1 reticulon 4 receptor-like 1 0.682463
CUL2 cullin 2 0.67246
FBXW8 F-box and WD repeat domain containing 8 0.665962
USP47 ubiquitin specific peptidase 47 0.665096
RNF7 ring finger protein 7 0.660776
FBXW4 F-box and WD repeat domain containing 4 0.642715
CDK2 cyclin-dependent kinase 2 0.636295
RTN4RL2 reticulon 4 receptor-like 2 0.634159
UBE2D1 ubiquitin-conjugating enzyme E2D 1 0.626483
CCNY cyclin Y 0.61883
FBXL3 F-box and leucine-rich repeat protein 3 0.601487
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.599802
ANK1 ankyrin 1, erythrocytic 0.593912
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.585523
UBA3 ubiquitin-like modifier activating enzyme 3 0.574244
CDK14 cyclin-dependent kinase 14 0.564262
FBXO3 F-box protein 3 0.563017
FBXO24 F-box protein 24 0.556387
TOB2 transducer of ERBB2, 2 0.554318
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 0.530028
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.523067
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.521023
RNF6 ring finger protein (C3H2C3 type) 6 0.505537
FBXO44 F-box protein 44 0.499853
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 0.476831
PLK4 polo-like kinase 4 0.476831
CHEK1 checkpoint kinase 1 0.461998
SOCS5 suppressor of cytokine signaling 5 0.459203
TRIM9 tripartite motif containing 9 0.436565
CCND1 cyclin D1 0.433801
CCNF cyclin F 0.418468
TOB1 transducer of ERBB2, 1 0.418077
NLK nemo-like kinase 0.405193
WEE1 WEE1 G2 checkpoint kinase 0.396648
KIF14 kinesin family member 14 0.39471
PDCL3 phosducin-like 3 0.392001
CDC20 cell division cycle 20 0.380429
FBXO28 F-box protein 28 0.37505
KLHL2 kelch-like family member 2 0.367388
CUL3 cullin 3 0.352901
BCOR BCL6 corepressor 0.351002
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.347587
NOTCH1 notch 1 0.337373
BRAP BRCA1 associated protein 0.331719
MINK1 misshapen-like kinase 1 0.330213
CLOCK clock circadian regulator 0.325702
PARVB parvin, beta 0.322325
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 0.29623
FBXO17 F-box protein 17 0.294748
CCND3 cyclin D3 0.289199
GMNN geminin, DNA replication inhibitor 0.283295
ING3 inhibitor of growth family, member 3 0.281453
WNT1 wingless-type MMTV integration site family, member 1 0.280349
CIRBP cold inducible RNA binding protein 0.275569
FBXO32 F-box protein 32 0.268237
BTG2 BTG family, member 2 0.267505
KLF5 Kruppel-like factor 5 (intestinal) 0.262755
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.257652
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.255107
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.250751
HIPK2 homeodomain interacting protein kinase 2 0.244601
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.243879
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 0.242437
METAP2 methionyl aminopeptidase 2 0.239197
UBE2K ubiquitin-conjugating enzyme E2K 0.230958
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 0.215063
SMAD9 SMAD family member 9 0.206766
AXIN1 axin 1 0.205399
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.205059
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.204718
PCDH8 protocadherin 8 0.189539
KDM2B lysine (K)-specific demethylase 2B 0.188274
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.18516
CRY1 cryptochrome circadian clock 1 0.183935
CCNB1 cyclin B1 0.182723
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.179167
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.178011
TP53 tumor protein p53 0.172468
MYB v-myb avian myeloblastosis viral oncogene homolog 0.171937
PHGDH phosphoglycerate dehydrogenase 0.169604
CMA1 chymase 1, mast cell 0.168763
HCFC1 host cell factor C1 0.167611
POLH polymerase (DNA directed), eta 0.166405
CCNE1 cyclin E1 0.162763
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.160254
KITLG KIT ligand 0.158377
YAP1 Yes-associated protein 1 0.157578
CUL4A cullin 4A 0.157218
CDK1 cyclin-dependent kinase 1 0.140025