scf ubiquitin ligase complex Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). (Gene Ontology, GO_0019005)
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26 proteins localized to the scf ubiquitin ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
FBXL19 F-box and leucine-rich repeat protein 19 0.663342
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.663342
FBXO4 F-box protein 4 0.663342
FBXO6 F-box protein 6 0.663342
FBXO9 F-box protein 9 0.663342
FBXO44 F-box protein 44 0.663342
CUL1 cullin 1 0.663342
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 0.663342
FBXW11 F-box and WD repeat domain containing 11 0.663342
FBXO27 F-box protein 27 0.663342
FBXW5 F-box and WD repeat domain containing 5 0.663342
USP47 ubiquitin specific peptidase 47 0.663342
FBXL3 F-box and leucine-rich repeat protein 3 0.663342
FBXL5 F-box and leucine-rich repeat protein 5 0.663342
FBXO17 F-box protein 17 0.663342
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 0.663342
SKP1 S-phase kinase-associated protein 1 0.663342
CCNF cyclin F 0.663342
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.663342
FBXL15 F-box and leucine-rich repeat protein 15 0.663342
FBXO31 F-box protein 31 0.663342
FBXO25 F-box protein 25 0.237908
FBXL7 F-box and leucine-rich repeat protein 7 0.237908
FBXO2 F-box protein 2 0.237908
FBXO15 F-box protein 15 0.03318
FBXW8 F-box and WD repeat domain containing 8 0.03318