sarcoma Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A usually aggressive malignant mesenchymal cell tumor most commonly arising from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The prognosis depends largely on the degree of differentiation (grade) of the tumor. Representative subtypes are liposarcoma, leiomyosarcoma, osteosarcoma, and chondrosarcoma.|A malignant mesenchymal neoplasm arising exclusively from the soft tissues. Representative examples include soft tissue sarcoma, extraosseous Ewing sarcoma/peripheral primitive neuroectodermal tumor, and malignant hemangiopericytoma.|Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.|A cancer that affects connective tissue resulting in mesoderm proliferation.|A malignant mesenchymal neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive tissues excluding the bones.|Type of cancer of the bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. (Experimental Factor Ontology, EFO_0000691)
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Genes

313 genes co-occuring with the biological term sarcoma in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALK anaplastic lymphoma receptor tyrosine kinase
ALOX5 arachidonate 5-lipoxygenase
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANG angiogenin, ribonuclease, RNase A family, 5
ANGPTL4 angiopoietin-like 4
ANPEP alanyl (membrane) aminopeptidase
APC adenomatous polyposis coli
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATF1 activating transcription factor 1
ATXN2 ataxin 2
AURKA aurora kinase A
AURKB aurora kinase B
AXL AXL receptor tyrosine kinase
BAD BCL2-associated agonist of cell death
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCOR BCL6 corepressor
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRAF B-Raf proto-oncogene, serine/threonine kinase
BSG basigin (Ok blood group)
CA9 carbonic anhydrase IX
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCAR2 cell cycle and apoptosis regulator 2
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNB3 cyclin B3
CCND1 cyclin D1
CCNE1 cyclin E1
CD109 CD109 molecule
CD248 CD248 molecule, endosialin
CD33 CD33 molecule
CD34 CD34 molecule
CD40LG CD40 ligand
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD82 CD82 molecule
CD86 CD86 molecule
CD99 CD99 molecule
CDC25A cell division cycle 25A
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK3 cyclin-dependent kinase 3
CDK6 cyclin-dependent kinase 6
CDK8 cyclin-dependent kinase 8
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CFL1 cofilin 1 (non-muscle)
CIC capicua transcriptional repressor
CLDN1 claudin 1
CLDN7 claudin 7
CLTA clathrin, light chain A
COL11A2 collagen, type XI, alpha 2
CREB1 cAMP responsive element binding protein 1
CREB3L1 cAMP responsive element binding protein 3-like 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRP C-reactive protein, pentraxin-related
CSPG4 chondroitin sulfate proteoglycan 4
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR6 chemokine (C-X-C motif) receptor 6
DDIT3 DNA-damage-inducible transcript 3
DEFB4A defensin, beta 4A
DKK2 dickkopf WNT signaling pathway inhibitor 2
DLL4 delta-like 4 (Drosophila)
DRAM1 DNA-damage regulated autophagy modulator 1
DSP desmoplakin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUX4 double homeobox 4
DUX4L1 double homeobox 4 like 1
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
EGR2 early growth response 2
ELAVL1 ELAV like RNA binding protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENG endoglin
EPHA2 EPH receptor A2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EWSR1 EWS RNA-binding protein 1
EYA3 EYA transcriptional coactivator and phosphatase 3
EZR ezrin
FAS Fas cell surface death receptor
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
FES FES proto-oncogene, tyrosine kinase
FGF2 fibroblast growth factor 2 (basic)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOXM1 forkhead box M1
FOXO4 forkhead box O4
FUS FUS RNA binding protein
FZD3 frizzled class receptor 3
GAB1 GRB2-associated binding protein 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GPC3 glypican 3
GSK3B glycogen synthase kinase 3 beta
GSTM4 glutathione S-transferase mu 4
HBEGF heparin-binding EGF-like growth factor
HDGF hepatoma-derived growth factor
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HP haptoglobin
HPSE heparanase
HRAS Harvey rat sarcoma viral oncogene homolog
HSPB1 heat shock 27kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
IL2RB interleukin 2 receptor, beta
IL3RA interleukin 3 receptor, alpha (low affinity)
IL4 interleukin 4
IL6 interleukin 6
INHA inhibin, alpha
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAG1 jagged 1
KCMF1 potassium channel modulatory factor 1
KDM1A lysine (K)-specific demethylase 1A
KDR kinase insert domain receptor
KEAP1 kelch-like ECH-associated protein 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF6 Kruppel-like factor 6
KMT2A lysine (K)-specific methyltransferase 2A
KRT17 keratin 17, type I
LATS1 large tumor suppressor kinase 1
LGALS1 lectin, galactoside-binding, soluble, 1
LPAR3 lysophosphatidic acid receptor 3
LPAR5 lysophosphatidic acid receptor 5
LRP1 low density lipoprotein receptor-related protein 1
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK14 mitogen-activated protein kinase 14
MAPT microtubule-associated protein tau
MCL1 myeloid cell leukemia 1
MDK midkine (neurite growth-promoting factor 2)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MET MET proto-oncogene, receptor tyrosine kinase
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MGMT O-6-methylguanine-DNA methyltransferase
MIR106A microRNA 106a
MIR125B2 microRNA 125b-2
MIR145 microRNA 145
MIR21 microRNA 21
MIR29A microRNA 29a
MIR30A microRNA 30a
MIR31 microRNA 31
MIR34A microRNA 34a
MIR363 microRNA 363
MIR708 microRNA 708
MIRLET7A1 microRNA let-7a-1
MITF microphthalmia-associated transcription factor
MKI67 marker of proliferation Ki-67
MLANA melan-A
MLH1 mutL homolog 1
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MSH2 mutS homolog 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC4 mucin 4, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NCAM1 neural cell adhesion molecule 1
NCOA3 nuclear receptor coactivator 3
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGFR nerve growth factor receptor
NKX2-2 NK2 homeobox 2
NOV nephroblastoma overexpressed
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPY1R neuropeptide Y receptor Y1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRG1 neuregulin 1
OSM oncostatin M
PARP1 poly (ADP-ribose) polymerase 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX2 paired box 2
PAX3 paired box 3
PAX8 paired box 8
PBRM1 polybromo 1
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PGR progesterone receptor
PIAS4 protein inhibitor of activated STAT, 4
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIWIL1 piwi-like RNA-mediated gene silencing 1
PIWIL2 piwi-like RNA-mediated gene silencing 2
PIWIL4 piwi-like RNA-mediated gene silencing 4
PLAGL1 pleiomorphic adenoma gene-like 1
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLD2 phospholipase D2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PML promyelocytic leukemia
POU4F1 POU class 4 homeobox 1
PRKCB protein kinase C, beta
PROM1 prominin 1
PROX1 prospero homeobox 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTPRD protein tyrosine phosphatase, receptor type, D
PTX3 pentraxin 3, long
PVR poliovirus receptor
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD51 RAD51 recombinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RB1 retinoblastoma 1
RCAN1 regulator of calcineurin 1
RPS6 ribosomal protein S6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RUNX3 runt-related transcription factor 3
SALL2 spalt-like transcription factor 2
SALL4 spalt-like transcription factor 4
SCRN1 secernin 1
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIRT1 sirtuin 1
SKI SKI proto-oncogene
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SNAI1 snail family zinc finger 1
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOD2 superoxide dismutase 2, mitochondrial
SOX10 SRY (sex determining region Y)-box 10
SOX2 SRY (sex determining region Y)-box 2
SP1 Sp1 transcription factor
SPP1 secreted phosphoprotein 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SS18 synovial sarcoma translocation, chromosome 18
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1
SSX1 synovial sarcoma, X breakpoint 1
SSX2 synovial sarcoma, X breakpoint 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYP synaptophysin
TARDBP TAR DNA binding protein
TERT telomerase reverse transcriptase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFE3 transcription factor binding to IGHM enhancer 3
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNPO1 transportin 1
TNPO2 transportin 2
TP53 tumor protein p53
TPD52 tumor protein D52
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIP6 thyroid hormone receptor interactor 6
TSC1 tuberous sclerosis 1
TWIST1 twist family bHLH transcription factor 1
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VIM vimentin
WEE1 WEE1 G2 checkpoint kinase
WNT1 wingless-type MMTV integration site family, member 1
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
XAGE1E X antigen family, member 1E
XBP1 X-box binding protein 1
XCR1 chemokine (C motif) receptor 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon