saquinavir-3549 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the saquinavir-3549 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACPP acid phosphatase, prostate
ACSM1 acyl-CoA synthetase medium-chain family member 1
ACTN2 actinin, alpha 2
ADAM22 ADAM metallopeptidase domain 22
AIM1L absent in melanoma 1-like
ARID5A AT rich interactive domain 5A (MRF1-like)
ASGR2 asialoglycoprotein receptor 2
ATN1 atrophin 1
BDKRB1 bradykinin receptor B1
BMP4 bone morphogenetic protein 4
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CAPN15 calpain 15
CD22 CD22 molecule
CDC14A cell division cycle 14A
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CES3 carboxylesterase 3
CLDN17 claudin 17
CSNK1G1 casein kinase 1, gamma 1
CTIF CBP80/20-dependent translation initiation factor
DCBLD2 discoidin, CUB and LCCL domain containing 2
DEFA4 defensin, alpha 4, corticostatin
DENND5B DENN/MADD domain containing 5B
DEPDC5 DEP domain containing 5
DGKI diacylglycerol kinase, iota
DHRS12 dehydrogenase/reductase (SDR family) member 12
DSC3 desmocollin 3
EN2 engrailed homeobox 2
ESPN espin
FBXO4 F-box protein 4
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FN1 fibronectin 1
FOXO4 forkhead box O4
FRAS1 Fraser extracellular matrix complex subunit 1
FRMD1 FERM domain containing 1
FRMD4A FERM domain containing 4A
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GPER1 G protein-coupled estrogen receptor 1
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DRA major histocompatibility complex, class II, DR alpha
HOMER3 homer scaffolding protein 3
HRG histidine-rich glycoprotein
IHH indian hedgehog
IPCEF1 interaction protein for cytohesin exchange factors 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
KDM4B lysine (K)-specific demethylase 4B
KLHL22 kelch-like family member 22
LCMT2 leucine carboxyl methyltransferase 2
LEFTY2 left-right determination factor 2
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LRRK1 leucine-rich repeat kinase 1
MAPK11 mitogen-activated protein kinase 11
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MTMR7 myotubularin related protein 7
NECAB2 N-terminal EF-hand calcium binding protein 2
NF1 neurofibromin 1
NOL10 nucleolar protein 10
NR4A1 nuclear receptor subfamily 4, group A, member 1
OBSL1 obscurin-like 1
OPRK1 opioid receptor, kappa 1
PADI3 peptidyl arginine deiminase, type III
PALM paralemmin
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLCB2 phospholipase C, beta 2
PPP5C protein phosphatase 5, catalytic subunit
PRAME preferentially expressed antigen in melanoma
PRKG2 protein kinase, cGMP-dependent, type II
PSD3 pleckstrin and Sec7 domain containing 3
PTGDR2 prostaglandin D2 receptor 2
QKI QKI, KH domain containing, RNA binding
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RND1 Rho family GTPase 1
RSG1 REM2 and RAB-like small GTPase 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SIX6 SIX homeobox 6
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SNED1 sushi, nidogen and EGF-like domains 1
SOAT2 sterol O-acyltransferase 2
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STAB2 stabilin 2
SUGP1 SURP and G patch domain containing 1
TBL1Y transducin (beta)-like 1, Y-linked
TM4SF4 transmembrane 4 L six family member 4
TMEM204 transmembrane protein 204
TOP3B topoisomerase (DNA) III beta
TPSAB1 tryptase alpha/beta 1
TTLL5 tubulin tyrosine ligase-like family member 5
TUBA3C tubulin, alpha 3c
UBA6 ubiquitin-like modifier activating enzyme 6
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
WDR33 WD repeat domain 33
ZBTB18 zinc finger and BTB domain containing 18
ZFP36L1 ZFP36 ring finger protein-like 1
ZIM2 zinc finger, imprinted 2

decreased expression

Symbol Name
ACTL8 actin-like 8
AHDC1 AT hook, DNA binding motif, containing 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
ANXA2P3 annexin A2 pseudogene 3
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BAHCC1 BAH domain and coiled-coil containing 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BPGM 2,3-bisphosphoglycerate mutase
BTD biotinidase
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CALCOCO1 calcium binding and coiled-coil domain 1
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCNK cyclin K
CCNL2 cyclin L2
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDK3 cyclin-dependent kinase 3
CDK9 cyclin-dependent kinase 9
CDKL3 cyclin-dependent kinase-like 3
CFAP44 cilia and flagella associated protein 44
CIDEC cell death-inducing DFFA-like effector c
CXADR coxsackie virus and adenovirus receptor
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DMC1 DNA meiotic recombinase 1
DNAL4 dynein, axonemal, light chain 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSCAM Down syndrome cell adhesion molecule
EFCAB2 EF-hand calcium binding domain 2
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
FKBP5 FK506 binding protein 5
FURIN furin (paired basic amino acid cleaving enzyme)
GUSBP3 glucuronidase, beta pseudogene 3
IFT81 intraflagellar transport 81
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KLHL26 kelch-like family member 26
KLK5 kallikrein-related peptidase 5
LAMB2 laminin, beta 2 (laminin S)
LIN7A lin-7 homolog A (C. elegans)
LRRC37A2 leucine rich repeat containing 37, member A2
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MED18 mediator complex subunit 18
MEIS2 Meis homeobox 2
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MON1B MON1 secretory trafficking family member B
MPDU1 mannose-P-dolichol utilization defect 1
NBEAL2 neurobeachin-like 2
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
OLFML2A olfactomedin-like 2A
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PANX1 pannexin 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHA6 pleckstrin homology domain containing, family A member 6
QTRT1 queuine tRNA-ribosyltransferase 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RNF31 ring finger protein 31
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
S100A4 S100 calcium binding protein A4
SARS2 seryl-tRNA synthetase 2, mitochondrial
SHARPIN SHANK-associated RH domain interactor
SIX1 SIX homeobox 1
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC12A8 solute carrier family 12, member 8
SLC12A9 solute carrier family 12, member 9
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNHG20 small nucleolar RNA host gene 20
SNX16 sorting nexin 16
SPINK4 serine peptidase inhibitor, Kazal type 4
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAG3 stromal antigen 3
STON1 stonin 1
SUN2 Sad1 and UNC84 domain containing 2
TARP TCR gamma alternate reading frame protein
TM6SF1 transmembrane 6 superfamily member 1
TMEM184B transmembrane protein 184B
TMEM209 transmembrane protein 209
TMEM53 transmembrane protein 53
TRAF2 TNF receptor-associated factor 2
TRIM13 tripartite motif containing 13
TRPV1 transient receptor potential cation channel, subfamily V, member 1
ZC3H3 zinc finger CCCH-type containing 3
ZHX3 zinc fingers and homeoboxes 3
ZNF324 zinc finger protein 324
ZNF586 zinc finger protein 586
ZNF652 zinc finger protein 652
ZNF701 zinc finger protein 701
ZNF768 zinc finger protein 768
ZSCAN26 zinc finger and SCAN domain containing 26