santonin-4531 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the santonin-4531 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM23 ADAM metallopeptidase domain 23
ADGRL3 adhesion G protein-coupled receptor L3
ADGRV1 adhesion G protein-coupled receptor V1
AKAP1 A kinase (PRKA) anchor protein 1
AQP5 aquaporin 5
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C22ORF46 chromosome 22 open reading frame 46
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCDC85C coiled-coil domain containing 85C
CD1C CD1c molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CISH cytokine inducible SH2-containing protein
CLSTN3 calsyntenin 3
COL4A6 collagen, type IV, alpha 6
CUL7 cullin 7
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DCTN2 dynactin 2 (p50)
DKKL1 dickkopf-like 1
DOCK6 dedicator of cytokinesis 6
DST dystonin
DSTYK dual serine/threonine and tyrosine protein kinase
E2F4 E2F transcription factor 4, p107/p130-binding
EMC3 ER membrane protein complex subunit 3
ETV6 ets variant 6
FAM118A family with sequence similarity 118, member A
FBXO22 F-box protein 22
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGF5 fibroblast growth factor 5
FRMD4A FERM domain containing 4A
GMPR guanosine monophosphate reductase
GPER1 G protein-coupled estrogen receptor 1
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPNMB glycoprotein (transmembrane) nmb
GPR22 G protein-coupled receptor 22
GRM8 glutamate receptor, metabotropic 8
GSN-AS1 GSN antisense RNA 1
HDAC11 histone deacetylase 11
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IDI2-AS1 IDI2 antisense RNA 1
KANSL3 KAT8 regulatory NSL complex subunit 3
KIF1C kinesin family member 1C
LAT2 linker for activation of T cells family, member 2
MAN1A2 mannosidase, alpha, class 1A, member 2
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MCM3AP minichromosome maintenance complex component 3 associated protein
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MLXIP MLX interacting protein
MLYCD malonyl-CoA decarboxylase
MVB12B multivesicular body subunit 12B
NEFM neurofilament, medium polypeptide
NEK11 NIMA-related kinase 11
NR5A2 nuclear receptor subfamily 5, group A, member 2
OR12D3 olfactory receptor, family 12, subfamily D, member 3
PDE4D phosphodiesterase 4D, cAMP-specific
PEX3 peroxisomal biogenesis factor 3
PHF2 PHD finger protein 2
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POM121L2 POM121 transmembrane nucleoporin-like 2
PRPF18 pre-mRNA processing factor 18
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PTPRR protein tyrosine phosphatase, receptor type, R
RBMS2 RNA binding motif, single stranded interacting protein 2
RIMS3 regulating synaptic membrane exocytosis 3
RNF6 ring finger protein (C3H2C3 type) 6
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100A5 S100 calcium binding protein A5
SCN1B sodium channel, voltage gated, type I beta subunit
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLC25A30 solute carrier family 25, member 30
SLC31A1 solute carrier family 31 (copper transporter), member 1
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2
SSBP2 single-stranded DNA binding protein 2
STEAP4 STEAP family member 4
STXBP5L syntaxin binding protein 5-like
SYCE1L synaptonemal complex central element protein 1-like
SYT12 synaptotagmin XII
TCP11 t-complex 11, testis-specific
TGFB2 transforming growth factor, beta 2
TIMP4 TIMP metallopeptidase inhibitor 4
TLX2 T-cell leukemia homeobox 2
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNIK TRAF2 and NCK interacting kinase
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TTN titin
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
XDH xanthine dehydrogenase
ZC2HC1C zinc finger, C2HC-type containing 1C
ZCCHC4 zinc finger, CCHC domain containing 4
ZNF236 zinc finger protein 236
ZNF609 zinc finger protein 609
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
AATK apoptosis-associated tyrosine kinase
ABHD17B abhydrolase domain containing 17B
ABHD8 abhydrolase domain containing 8
ACBD4 acyl-CoA binding domain containing 4
ADAM2 ADAM metallopeptidase domain 2
ANXA2P1 annexin A2 pseudogene 1
ANXA2P3 annexin A2 pseudogene 3
ARL14 ADP-ribosylation factor-like 14
BAAT bile acid CoA:amino acid N-acyltransferase
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BCL9 B-cell CLL/lymphoma 9
C1S complement component 1, s subcomponent
C7ORF69 chromosome 7 open reading frame 69
CCP110 centriolar coiled coil protein 110kDa
CD101 CD101 molecule
CDADC1 cytidine and dCMP deaminase domain containing 1
CEP170B centrosomal protein 170B
CES3 carboxylesterase 3
CLIC3 chloride intracellular channel 3
CNTLN centlein, centrosomal protein
CPED1 cadherin-like and PC-esterase domain containing 1
CXCL3 chemokine (C-X-C motif) ligand 3
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DCAF10 DDB1 and CUL4 associated factor 10
DNAH7 dynein, axonemal, heavy chain 7
DNAL4 dynein, axonemal, light chain 4
DTX2 deltex 2, E3 ubiquitin ligase
EGR2 early growth response 2
EN1 engrailed homeobox 1
ERF Ets2 repressor factor
ERN2 endoplasmic reticulum to nucleus signaling 2
FBRS fibrosin
FURIN furin (paired basic amino acid cleaving enzyme)
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GRAMD4 GRAM domain containing 4
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HDAC7 histone deacetylase 7
HIST1H1T histone cluster 1, H1t
HIST1H2BN histone cluster 1, H2bn
HIST1H4D histone cluster 1, H4d
HIST2H2AA3 histone cluster 2, H2aa3
HLA-DMA major histocompatibility complex, class II, DM alpha
HOXC13 homeobox C13
IQSEC2 IQ motif and Sec7 domain 2
KDM8 lysine (K)-specific demethylase 8
KLF3 Kruppel-like factor 3 (basic)
LNPEP leucyl/cystinyl aminopeptidase
LOC257152 uncharacterized LOC257152
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MOB3B MOB kinase activator 3B
MRPL28 mitochondrial ribosomal protein L28
MT1M metallothionein 1M
MTA2 metastasis associated 1 family, member 2
MX1 MX dynamin-like GTPase 1
NAT6 N-acetyltransferase 6 (GCN5-related)
NPFFR1 neuropeptide FF receptor 1
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PCDHGB5 protocadherin gamma subfamily B, 5
PDE12 phosphodiesterase 12
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PGPEP1 pyroglutamyl-peptidase I
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLD2 phospholipase D2
PLXNB3 plexin B3
PRB3 proline-rich protein BstNI subfamily 3
PRSS53 protease, serine, 53
PRSS8 protease, serine, 8
RAB36 RAB36, member RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RIN1 Ras and Rab interactor 1
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RUSC2 RUN and SH3 domain containing 2
SEPP1 selenoprotein P, plasma, 1
SERGEF secretion regulating guanine nucleotide exchange factor
SIX1 SIX homeobox 1
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMAD7 SMAD family member 7
SNPH syntaphilin
STON1 stonin 1
TAOK1 TAO kinase 1
THRAP3 thyroid hormone receptor associated protein 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM132A transmembrane protein 132A
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TOM1 target of myb1 (chicken)
TSKU tsukushi, small leucine rich proteoglycan
TTC30A tetratricopeptide repeat domain 30A
USP20 ubiquitin specific peptidase 20
WNT7A wingless-type MMTV integration site family, member 7A
ZBTB22 zinc finger and BTB domain containing 22
ZFP30 ZFP30 zinc finger protein
ZNF253 zinc finger protein 253
ZNF415 zinc finger protein 415
ZNF510 zinc finger protein 510