ruffle membrane Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The portion of the plasma membrane surrounding a ruffle. (Gene Ontology, GO_0032587)
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Genes

194 proteins co-occuring with the ruffle membrane cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 1.73058
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.72745
CDC42 cell division cycle 42 1.64135
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.40075
CTTN cortactin 1.29424
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.21894
PLEK pleckstrin 1.18954
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 1.08628
MCF2 MCF.2 cell line derived transforming sequence 1.07106
VAV2 vav 2 guanine nucleotide exchange factor 1.03729
PKN1 protein kinase N1 0.990247
ELMO3 engulfment and cell motility 3 0.977589
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.966474
EZR ezrin 0.962146
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 0.931245
ARF6 ADP-ribosylation factor 6 0.878712
SPRY2 sprouty homolog 2 (Drosophila) 0.824041
MSN moesin 0.81257
GRB2 growth factor receptor-bound protein 2 0.773645
PXN paxillin 0.748641
SPATA13 spermatogenesis associated 13 0.74322
FSCN1 fascin actin-bundling protein 1 0.728836
PTPN20 protein tyrosine phosphatase, non-receptor type 20 0.715902
NCKIPSD NCK interacting protein with SH3 domain 0.709251
SASH1 SAM and SH3 domain containing 1 0.692078
RDX radixin 0.682027
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.67463
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.648291
ITGB1BP1 integrin beta 1 binding protein 1 0.646145
CYTH4 cytohesin 4 0.643572
VCL vinculin 0.640145
MTMR9 myotubularin related protein 9 0.63544
TIAM1 T-cell lymphoma invasion and metastasis 1 0.633732
IQGAP1 IQ motif containing GTPase activating protein 1 0.632451
FGD5 FYVE, RhoGEF and PH domain containing 5 0.628613
ARHGAP35 Rho GTPase activating protein 35 0.623504
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 0.615437
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 0.613742
DOCK1 dedicator of cytokinesis 1 0.603174
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.601487
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.597697
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.583431
NEXN nexilin (F actin binding protein) 0.581758
PLCD1 phospholipase C, delta 1 0.568001
MYO18A myosin XVIIIA 0.563847
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.559285
GBP5 guanylate binding protein 5 0.549773
FN1 fibronectin 1 0.541529
ARHGAP24 Rho GTPase activating protein 24 0.538238
ELMO2 engulfment and cell motility 2 0.53413
IQGAP2 IQ motif containing GTPase activating protein 2 0.523476
PLCG1 phospholipase C, gamma 1 0.520206
PARD3B par-3 family cell polarity regulator beta 0.517756
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 0.51694
PARVB parvin, beta 0.514085
PARVG parvin, gamma 0.505537
EPS8 epidermal growth factor receptor pathway substrate 8 0.503506
FLNA filamin A, alpha 0.50107
EPB41 erythrocyte membrane protein band 4.1 0.50107
NRG4 neuregulin 4 0.498636
PLEK2 pleckstrin 2 0.492966
MYO6 myosin VI 0.4865
GMFG glia maturation factor, gamma 0.482467
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.481258
RHOQ ras homolog family member Q 0.481258
PLS1 plastin 1 0.480855
TESC tescalcin 0.48005
MCF2L MCF.2 cell line derived transforming sequence-like 0.48005
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.477636
CALD1 caldesmon 1 0.476429
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 0.475223
CYTH1 cytohesin 1 0.472011
MTMR6 myotubularin related protein 6 0.469604
AIF1 allograft inflammatory factor 1 0.466399
JUN jun proto-oncogene 0.457606
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.457208
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 0.455613
MAP3K12 mitogen-activated protein kinase kinase kinase 12 0.452825
CPVL carboxypeptidase, vitellogenic-like 0.45004
FHOD1 formin homology 2 domain containing 1 0.445672
VAV1 vav 1 guanine nucleotide exchange factor 0.444482
EGFR epidermal growth factor receptor 0.441312
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 0.439333
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.437751
SPRR1A small proline-rich protein 1A 0.43696
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.434196
ARHGAP1 Rho GTPase activating protein 1 0.423174
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 0.420428
RECK reversion-inducing-cysteine-rich protein with kazal motifs 0.419252
GAS7 growth arrest-specific 7 0.417685
PLS3 plastin 3 0.416511
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.415728
VAV3 vav 3 guanine nucleotide exchange factor 0.413382
NOX3 NADPH oxidase 3 0.412992
AKAP11 A kinase (PRKA) anchor protein 11 0.410649
LAYN layilin 0.409869
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.403248
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.402859
BCAR1 breast cancer anti-estrogen resistance 1 0.39471
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 0.393936
CD2AP CD2-associated protein 0.392775
PLD2 phospholipase D2 0.389296
ARHGAP22 Rho GTPase activating protein 22 0.388523
GRAP2 GRB2-related adaptor protein 2 0.382354
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 0.382354
BTK Bruton agammaglobulinemia tyrosine kinase 0.374283
MAP3K10 mitogen-activated protein kinase kinase kinase 10 0.372749
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.37045
ARF5 ADP-ribosylation factor 5 0.370067
EPHB4 EPH receptor B4 0.366623
SPHK1 sphingosine kinase 1 0.366623
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 0.364713
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.364713
SNX18 sorting nexin 18 0.357086
RUFY1 RUN and FYVE domain containing 1 0.353282
SNX33 sorting nexin 33 0.351382
PPP3R2 protein phosphatase 3, regulatory subunit B, beta 0.349863
CRIP1 cysteine-rich protein 1 (intestinal) 0.342285
TWF2 twinfilin actin binding protein 2 0.340395
TESK1 testis-specific kinase 1 0.338128
RAP2B RAP2B, member of RAS oncogene family 0.333602
SAR1A secretion associated, Ras related GTPase 1A 0.327205
ARF3 ADP-ribosylation factor 3 0.326453
RAB1B RAB1B, member RAS oncogene family 0.323825
ASB2 ankyrin repeat and SOCS box containing 2 0.323075
ARHGAP31 Rho GTPase activating protein 31 0.322325
BCAR3 breast cancer anti-estrogen resistance 3 0.305515
RAB10 RAB10, member RAS oncogene family 0.281453
MYO10 myosin X 0.27998
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.274101
MICALL2 MICAL-like 2 0.272633
ADGRE2 adhesion G protein-coupled receptor E2 0.268969
NISCH nischarin 0.268237
SYNJ2 synaptojanin 2 0.268237
ARHGAP18 Rho GTPase activating protein 18 0.267505
MAP2K3 mitogen-activated protein kinase kinase 3 0.266774
STARD13 StAR-related lipid transfer (START) domain containing 13 0.265677
ADAP1 ArfGAP with dual PH domains 1 0.265677
RAB5C RAB5C, member RAS oncogene family 0.258745
FMN1 formin 1 0.257289
PTK6 protein tyrosine kinase 6 0.254743
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 0.249664
PDE9A phosphodiesterase 9A 0.243519
PSD pleckstrin and Sec7 domain containing 0.241716
SH3KBP1 SH3-domain kinase binding protein 1 0.23776
LIMA1 LIM domain and actin binding 1 0.234533
SH3PXD2B SH3 and PX domains 2B 0.233101
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.230601
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.229176
HOXC8 homeobox C8 0.225622
EFNB2 ephrin-B2 0.22385
RAB5B RAB5B, member RAS oncogene family 0.223497
NOX1 NADPH oxidase 1 0.223143
ARHGAP5 Rho GTPase activating protein 5 0.222436
PFN1 profilin 1 0.222436
ARF1 ADP-ribosylation factor 1 0.219969
MYO1E myosin IE 0.218563
ELMO1 engulfment and cell motility 1 0.215761
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.214366
CORO1C coronin, actin binding protein, 1C 0.212974
MYO1C myosin IC 0.21228
VILL villin-like 0.209513
MARCKS myristoylated alanine-rich protein kinase C substrate 0.206766
CCNG2 cyclin G2 0.20574
BMX BMX non-receptor tyrosine kinase 0.204039
TPM1 tropomyosin 1 (alpha) 0.199659
TRAF4 TNF receptor-associated factor 4 0.19733
CSF1 colony stimulating factor 1 (macrophage) 0.196999
THBS1 thrombospondin 1 0.196669
FYN FYN proto-oncogene, Src family tyrosine kinase 0.196339
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 0.196339
HRAS Harvey rat sarcoma viral oncogene homolog 0.195025
PARD3 par-3 family cell polarity regulator 0.195025
RAB5A RAB5A, member RAS oncogene family 0.1921
KRIT1 KRIT1, ankyrin repeat containing 0.189222
NBPF8 neuroblastoma breakpoint family, member 8 0.18859
WAS Wiskott-Aldrich syndrome 0.184241
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.183025
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.181524
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.181227
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.18093
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.178877
LTBP3 latent transforming growth factor beta binding protein 3 0.178588
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.178011
RND2 Rho family GTPase 2 0.173003
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.172468
MYO1A myosin IA 0.171673
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.171673
SH2B3 SH2B adaptor protein 3 0.16935
LTBP2 latent transforming growth factor beta binding protein 2 0.167856
RAB34 RAB34, member RAS oncogene family 0.166884
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.164315
GSK3A glycogen synthase kinase 3 alpha 0.161905
SNX5 sorting nexin 5 0.158129