roxithromycin-4778 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the roxithromycin-4778 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGB androglobin
AFAP1 actin filament associated protein 1
ALDOB aldolase B, fructose-bisphosphate
AMACR alpha-methylacyl-CoA racemase
AMPD3 adenosine monophosphate deaminase 3
ANKLE2 ankyrin repeat and LEM domain containing 2
AP3S2 adaptor-related protein complex 3, sigma 2 subunit
AREG amphiregulin
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BTN3A3 butyrophilin, subfamily 3, member A3
C14ORF105 chromosome 14 open reading frame 105
C4BPA complement component 4 binding protein, alpha
CA12 carbonic anhydrase XII
CABP1 calcium binding protein 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCDC33 coiled-coil domain containing 33
CCDC57 coiled-coil domain containing 57
CD28 CD28 molecule
CD4 CD4 molecule
CDHR5 cadherin-related family member 5
CHKB choline kinase beta
CLIC2 chloride intracellular channel 2
CNPY4 canopy FGF signaling regulator 4
COL5A2 collagen, type V, alpha 2
CYLD cylindromatosis (turban tumor syndrome)
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EMID1 EMI domain containing 1
EML2 echinoderm microtubule associated protein like 2
EPHA1 EPH receptor A1
EPOR erythropoietin receptor
FGF6 fibroblast growth factor 6
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAB1 GRB2-associated binding protein 1
GRIK5 glutamate receptor, ionotropic, kainate 5
HIPK2 homeodomain interacting protein kinase 2
HOXA4 homeobox A4
KANK3 KN motif and ankyrin repeat domains 3
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0226L KIAA0226-like
KNG1 kininogen 1
KRT16 keratin 16, type I
KRT20 keratin 20, type I
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MALL mal, T-cell differentiation protein-like
MAP2K5 mitogen-activated protein kinase kinase 5
MEF2D myocyte enhancer factor 2D
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MPO myeloperoxidase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NCF4 neutrophil cytosolic factor 4, 40kDa
NCOA2 nuclear receptor coactivator 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NR5A2 nuclear receptor subfamily 5, group A, member 2
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)
OSGIN2 oxidative stress induced growth inhibitor family member 2
OVGP1 oviductal glycoprotein 1, 120kDa
PCDHA5 protocadherin alpha 5
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRDM9 PR domain containing 9
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTN pleiotrophin
PTPRA protein tyrosine phosphatase, receptor type, A
RAB11B RAB11B, member RAS oncogene family
RAD51B RAD51 paralog B
RBM12B-AS1 RBM12B antisense RNA 1
RGS5 regulator of G-protein signaling 5
RND2 Rho family GTPase 2
SGSM3 small G protein signaling modulator 3
SIRT5 sirtuin 5
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC26A1 solute carrier family 26 (anion exchanger), member 1
SLC35G2 solute carrier family 35, member G2
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SSX1 synovial sarcoma, X breakpoint 1
STOML1 stomatin (EPB72)-like 1
SYCE1L synaptonemal complex central element protein 1-like
TCP10 t-complex 10
TMEM212 transmembrane protein 212
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRBC1 T cell receptor beta constant 1
TRIM2 tripartite motif containing 2
TROVE2 TROVE domain family, member 2
VARS valyl-tRNA synthetase
VIPR2 vasoactive intestinal peptide receptor 2
WDR78 WD repeat domain 78
WSCD1 WSC domain containing 1
XYLB xylulokinase homolog (H. influenzae)
ZNF204P zinc finger protein 204, pseudogene

decreased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ACO1 aconitase 1, soluble
ACYP1 acylphosphatase 1, erythrocyte (common) type
AGO3 argonaute RISC catalytic component 3
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
BAGE B melanoma antigen
BPGM 2,3-bisphosphoglycerate mutase
C10ORF88 chromosome 10 open reading frame 88
C12ORF4 chromosome 12 open reading frame 4
CCDC88C coiled-coil domain containing 88C
CCDC91 coiled-coil domain containing 91
CEP72 centrosomal protein 72kDa
CHEK2 checkpoint kinase 2
CLK1 CDC-like kinase 1
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
CPOX coproporphyrinogen oxidase
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
ENO2 enolase 2 (gamma, neuronal)
EPHA4 EPH receptor A4
ERBB2IP erbb2 interacting protein
ERCC8 excision repair cross-complementation group 8
FAM169A family with sequence similarity 169, member A
GINS4 GINS complex subunit 4 (Sld5 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GLTSCR1 glioma tumor suppressor candidate region gene 1
GMEB1 glucocorticoid modulatory element binding protein 1
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HIST1H1D histone cluster 1, H1d
HIST1H2AI histone cluster 1, H2ai
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BI histone cluster 1, H2bi
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IRF6 interferon regulatory factor 6
KIF20B kinesin family member 20B
KLF11 Kruppel-like factor 11
KLHL21 kelch-like family member 21
LINC00115 long intergenic non-protein coding RNA 115
LPXN leupaxin
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MANBA mannosidase, beta A, lysosomal
MED23 mediator complex subunit 23
MED4 mediator complex subunit 4
MINPP1 multiple inositol-polyphosphate phosphatase 1
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
NEK11 NIMA-related kinase 11
NFE2L3 nuclear factor, erythroid 2-like 3
NR1D2 nuclear receptor subfamily 1, group D, member 2
PEX26 peroxisomal biogenesis factor 26
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLD3 phospholipase D family, member 3
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PPT2 palmitoyl-protein thioesterase 2
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PRSS22 protease, serine, 22
PTPN9 protein tyrosine phosphatase, non-receptor type 9
QTRT1 queuine tRNA-ribosyltransferase 1
RNFT2 ring finger protein, transmembrane 2
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1
SCAI suppressor of cancer cell invasion
SHCBP1 SHC SH2-domain binding protein 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNIP1 Smad nuclear interacting protein 1
SNX16 sorting nexin 16
SOAT1 sterol O-acyltransferase 1
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STX1A syntaxin 1A (brain)
TAOK1 TAO kinase 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCERG1 transcription elongation regulator 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TPRA1 transmembrane protein, adipocyte asscociated 1
TPST1 tyrosylprotein sulfotransferase 1
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSPAN15 tetraspanin 15
UBXN6 UBX domain protein 6
USP27X ubiquitin specific peptidase 27, X-linked
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR19 WD repeat domain 19
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBTB10 zinc finger and BTB domain containing 10
ZNF273 zinc finger protein 273
ZNF302 zinc finger protein 302
ZNF329 zinc finger protein 329
ZNF408 zinc finger protein 408
ZNF428 zinc finger protein 428
ZNF430 zinc finger protein 430
ZNF652 zinc finger protein 652
ZNF696 zinc finger protein 696
ZNF74 zinc finger protein 74
ZNF770 zinc finger protein 770
ZNF816 zinc finger protein 816
ZNF83 zinc finger protein 83